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Nivolumab/Opdivo
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Nivolumab/Opdivo

› Forums › General Melanoma Community › Nivolumab/Opdivo

  • Post
    • February 28, 2015 at 3:46 pm
    sstech
    Participant
      I have been on Opdivo treatment for 2 weeks and am continuing Tafinlar capsules twice a day for 2 more weeks. I know that the Opdivo is very new. I am only the second patient at M D Anderson Melanoma Clinic to be on this treatment. Just curious if there is anyone else on the Opdivo on this site that I can compare notes with. I was diagnosed 5/5/2012 and have been fighting like hell every since. I feel so blessed that the Opdivo was fast tracked through the FDA and is available right when I need it.
    Viewing 5 reply threads
    • Replies
        • February 28, 2015 at 4:12 pm
        Bubbles
        Participant

          I started the BMS anti-PD-1 product initially known by letters and numbers, then the name nivolumab, and after FDA approval Opdivo, as you noted, in a clinical trial in December 2010. My story and that of all the ratties who took it with me is on my blog. In our trial we were given nivo every 2 weeks for 6 months, then infusions every 3 months for 2 additional years. Dosing was at 1, 3, or 10 mg per kilo depending which cohort you were in. I was dosed at 1mg/kg. There was an NED arm as well as one with active disease. Since then, the trial has been expanded many times to include additional patients….some who had had dose limiting side effects to yervoy, an arm with the nivo/ipi combo, as well as others. Most of us have done very well. I remain NED. Ratties are pretty special people. I wish you well.  Celeste

          • February 28, 2015 at 4:12 pm
          Bubbles
          Participant

            I started the BMS anti-PD-1 product initially known by letters and numbers, then the name nivolumab, and after FDA approval Opdivo, as you noted, in a clinical trial in December 2010. My story and that of all the ratties who took it with me is on my blog. In our trial we were given nivo every 2 weeks for 6 months, then infusions every 3 months for 2 additional years. Dosing was at 1, 3, or 10 mg per kilo depending which cohort you were in. I was dosed at 1mg/kg. There was an NED arm as well as one with active disease. Since then, the trial has been expanded many times to include additional patients….some who had had dose limiting side effects to yervoy, an arm with the nivo/ipi combo, as well as others. Most of us have done very well. I remain NED. Ratties are pretty special people. I wish you well.  Celeste

            • February 28, 2015 at 4:12 pm
            Bubbles
            Participant

              I started the BMS anti-PD-1 product initially known by letters and numbers, then the name nivolumab, and after FDA approval Opdivo, as you noted, in a clinical trial in December 2010. My story and that of all the ratties who took it with me is on my blog. In our trial we were given nivo every 2 weeks for 6 months, then infusions every 3 months for 2 additional years. Dosing was at 1, 3, or 10 mg per kilo depending which cohort you were in. I was dosed at 1mg/kg. There was an NED arm as well as one with active disease. Since then, the trial has been expanded many times to include additional patients….some who had had dose limiting side effects to yervoy, an arm with the nivo/ipi combo, as well as others. Most of us have done very well. I remain NED. Ratties are pretty special people. I wish you well.  Celeste

                • February 28, 2015 at 6:15 pm
                sstech
                Participant
                  Thank you Celeste. After I posted this I came across the links you have posted. Thank you for sharing.
                  • February 28, 2015 at 6:15 pm
                  sstech
                  Participant
                    Thank you Celeste. After I posted this I came across the links you have posted. Thank you for sharing.
                    • February 28, 2015 at 6:15 pm
                    sstech
                    Participant
                      Thank you Celeste. After I posted this I came across the links you have posted. Thank you for sharing.
                    • March 1, 2015 at 7:09 pm
                    Mat
                    Participant

                      Just curious if the doctors at MDA recommended Opdivo over Keytruda and, if so, why?  Thanks.

                      • March 1, 2015 at 7:09 pm
                      Mat
                      Participant

                        Just curious if the doctors at MDA recommended Opdivo over Keytruda and, if so, why?  Thanks.

                          • March 9, 2015 at 11:27 am
                          sstech
                          Participant
                            My doctor explained it to me that she believed dosing every 2 weeks was more effective. I believe she called it dense drug dosing therapy. I have an illeostomy which can be a challenge at times. Lower dose more frequently we are hoping will decrease ostomy output and decrease dehydration and electrolyte imbalance.
                            • March 9, 2015 at 11:27 am
                            sstech
                            Participant
                              My doctor explained it to me that she believed dosing every 2 weeks was more effective. I believe she called it dense drug dosing therapy. I have an illeostomy which can be a challenge at times. Lower dose more frequently we are hoping will decrease ostomy output and decrease dehydration and electrolyte imbalance.
                              • March 9, 2015 at 11:27 am
                              sstech
                              Participant
                                My doctor explained it to me that she believed dosing every 2 weeks was more effective. I believe she called it dense drug dosing therapy. I have an illeostomy which can be a challenge at times. Lower dose more frequently we are hoping will decrease ostomy output and decrease dehydration and electrolyte imbalance.
                              • March 1, 2015 at 7:09 pm
                              Mat
                              Participant

                                Just curious if the doctors at MDA recommended Opdivo over Keytruda and, if so, why?  Thanks.

                            Viewing 5 reply threads
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