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Pemrbrolizumab and brain mets/ steroids
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Pemrbrolizumab and brain mets/ steroids

› Forums › General Melanoma Community › Pemrbrolizumab and brain mets/ steroids

  • Post
    • January 31, 2016 at 8:51 pm
    gcooperbl
    Participant

      Hi all

       

      just a bit of advice needed, my dad had a turn / dizzy spell / potential seizure he is on lower dose of steroids and has brain mets. Will the doctor slow down his immunotherapy? He got first cycle last week and not to today was fine. Due to get his second on the 11th feb…..anyone been through this? Any positive news for brain mets and pembro? 

       

      G

    Viewing 5 reply threads
    • Replies
        • January 31, 2016 at 9:44 pm
        Bubbles
        Participant

          G,

          Your dad will need to talk with his doc about his dizzy episode so that it can be sorted out and dealt with.  I doubt it had anything to do with Ketruda/pembo.  As far as anti-PD1 and brain mets (as well as ipi and BRAFi) here is a post which contains multiple additional links…one link is specifically to the preliminary results of a pembro study with foks with brain mets out of ASCO 2015:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/07/a-really-good-review-of-treatment-data.html

          I wish you and your dad my best. Celeste

          • January 31, 2016 at 9:44 pm
          Bubbles
          Participant

            G,

            Your dad will need to talk with his doc about his dizzy episode so that it can be sorted out and dealt with.  I doubt it had anything to do with Ketruda/pembo.  As far as anti-PD1 and brain mets (as well as ipi and BRAFi) here is a post which contains multiple additional links…one link is specifically to the preliminary results of a pembro study with foks with brain mets out of ASCO 2015:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/07/a-really-good-review-of-treatment-data.html

            I wish you and your dad my best. Celeste

              • January 31, 2016 at 11:10 pm
              gcooperbl
              Participant

                Thanks celeste he is being kept in by medics and kept an eye on hopefully it was just a minor setback. 

                do you know anything more re these new anti pdl1 drugs? He is BRAF negative so doctors told Us pembro was best out there bar trials…but if it doesn't work we need to look at other avenues. 

                thanks for your reply it makes sense….if the brain is full of t-cells and pembro works they should attack the cancer cells.

                • January 31, 2016 at 11:10 pm
                gcooperbl
                Participant

                  Thanks celeste he is being kept in by medics and kept an eye on hopefully it was just a minor setback. 

                  do you know anything more re these new anti pdl1 drugs? He is BRAF negative so doctors told Us pembro was best out there bar trials…but if it doesn't work we need to look at other avenues. 

                  thanks for your reply it makes sense….if the brain is full of t-cells and pembro works they should attack the cancer cells.

                  • February 1, 2016 at 1:09 am
                  Bubbles
                  Participant

                    If you use the search bubble on the top left of my blog and enter "anti-PD1" you will probably find more data than you want.  c

                    • February 1, 2016 at 1:09 am
                    Bubbles
                    Participant

                      If you use the search bubble on the top left of my blog and enter "anti-PD1" you will probably find more data than you want.  c

                      • February 1, 2016 at 1:17 am
                      Bubbles
                      Participant

                        Just realized I may have mis-read your comment…but same advice….except…type in "anti-PDL1" in the search bubble.  Sorry.  c

                        • February 1, 2016 at 1:17 am
                        Bubbles
                        Participant

                          Just realized I may have mis-read your comment…but same advice….except…type in "anti-PDL1" in the search bubble.  Sorry.  c

                          • February 1, 2016 at 1:17 am
                          Bubbles
                          Participant

                            Just realized I may have mis-read your comment…but same advice….except…type in "anti-PDL1" in the search bubble.  Sorry.  c

                            • February 1, 2016 at 1:09 am
                            Bubbles
                            Participant

                              If you use the search bubble on the top left of my blog and enter "anti-PD1" you will probably find more data than you want.  c

                              • January 31, 2016 at 11:10 pm
                              gcooperbl
                              Participant

                                Thanks celeste he is being kept in by medics and kept an eye on hopefully it was just a minor setback. 

                                do you know anything more re these new anti pdl1 drugs? He is BRAF negative so doctors told Us pembro was best out there bar trials…but if it doesn't work we need to look at other avenues. 

                                thanks for your reply it makes sense….if the brain is full of t-cells and pembro works they should attack the cancer cells.

                              • January 31, 2016 at 9:44 pm
                              Bubbles
                              Participant

                                G,

                                Your dad will need to talk with his doc about his dizzy episode so that it can be sorted out and dealt with.  I doubt it had anything to do with Ketruda/pembo.  As far as anti-PD1 and brain mets (as well as ipi and BRAFi) here is a post which contains multiple additional links…one link is specifically to the preliminary results of a pembro study with foks with brain mets out of ASCO 2015:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/07/a-really-good-review-of-treatment-data.html

                                I wish you and your dad my best. Celeste

                                • February 4, 2016 at 1:57 am
                                AllysonRuth
                                Participant

                                  HI,

                                  I had two brain mets at diagnosis.  I have been on pembro since October.  One of my brain mets is gone and the other one is shrinking.  I had radiation in combo with pembro.  The pembro seems to be working.  

                                  Good luck with your Dad.  I am so sorry.  Melanoma is bad business.  

                                  Allyson

                                  • February 4, 2016 at 1:57 am
                                  AllysonRuth
                                  Participant

                                    HI,

                                    I had two brain mets at diagnosis.  I have been on pembro since October.  One of my brain mets is gone and the other one is shrinking.  I had radiation in combo with pembro.  The pembro seems to be working.  

                                    Good luck with your Dad.  I am so sorry.  Melanoma is bad business.  

                                    Allyson

                                    • February 4, 2016 at 1:57 am
                                    AllysonRuth
                                    Participant

                                      HI,

                                      I had two brain mets at diagnosis.  I have been on pembro since October.  One of my brain mets is gone and the other one is shrinking.  I had radiation in combo with pembro.  The pembro seems to be working.  

                                      Good luck with your Dad.  I am so sorry.  Melanoma is bad business.  

                                      Allyson

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