MRF-Logo2019-Horizontal-RGB
Progression after 3 1/2 years on anti-pd1
REGISTER
The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Content within the patient forum is user-generated and has not been reviewed by medical professionals. Other sections of the Melanoma Research Foundation website include information that has been reviewed by medical professionals as appropriate. All medical decisions should be made in consultation with your doctor or other qualified medical professional.

Progression after 3 1/2 years on anti-pd1

› Forums › General Melanoma Community › Progression after 3 1/2 years on anti-pd1

  • Post
    • September 19, 2016 at 10:55 am
    Amanda
    Participant
      So my boyfriend randy was on clinical trial of now approved keytruda for 3 1/2 years before having progression of two new tumors in his thighs. We signed consent and are doing scans and blood work tomorrow in anticipation for starting a new trial combining the keytruda with an agent called sd-101 by dynavex where the agent is injected directly into one tumor one a week for the first 3 weeks followed by the keytruda and injection together every 3 weeks. Hopefully the sd-101 will introduce more killer cells to attack the tumors. This is done at ucla by Dr. Ribas and I’ll keep you all posted on results.

      Anyone here had experience or heard of the dynavex sd-101 combined with keytruda?

      Best wishes. Amanda.

    Viewing 8 reply threads
    • Replies
        • September 19, 2016 at 11:19 am
        Jubes
        Participant

          Hi. 

          Did he have stable disease after the trial. And where else were his tumours? I've never heard of your treatment but I would be very interested to know what the rate is of progressing after keytruda and also of your results. Keep us posted and thank you for posting

           

          anne-Louise 

          • September 19, 2016 at 11:19 am
          Jubes
          Participant

            Hi. 

            Did he have stable disease after the trial. And where else were his tumours? I've never heard of your treatment but I would be very interested to know what the rate is of progressing after keytruda and also of your results. Keep us posted and thank you for posting

             

            anne-Louise 

            • September 19, 2016 at 11:19 am
            Jubes
            Participant

              Hi. 

              Did he have stable disease after the trial. And where else were his tumours? I've never heard of your treatment but I would be very interested to know what the rate is of progressing after keytruda and also of your results. Keep us posted and thank you for posting

               

              anne-Louise 

              • September 19, 2016 at 11:56 am
              Bubbles
              Participant

                Dynavax sd 101 is an immunotherapy product they are injecting as an intralesional in the way they are using PV 10 and T-VEC. Here's a pretty good report explaining it….albeit from the company: http://www.dynavax.com/our-pipeline/cancer-immunotherapy/sd101/

                So sorry for your husband's progression, Amanda. Wishing you both well. Celeste

                • September 19, 2016 at 11:56 am
                Bubbles
                Participant

                  Dynavax sd 101 is an immunotherapy product they are injecting as an intralesional in the way they are using PV 10 and T-VEC. Here's a pretty good report explaining it….albeit from the company: http://www.dynavax.com/our-pipeline/cancer-immunotherapy/sd101/

                  So sorry for your husband's progression, Amanda. Wishing you both well. Celeste

                  • September 19, 2016 at 11:56 am
                  Bubbles
                  Participant

                    Dynavax sd 101 is an immunotherapy product they are injecting as an intralesional in the way they are using PV 10 and T-VEC. Here's a pretty good report explaining it….albeit from the company: http://www.dynavax.com/our-pipeline/cancer-immunotherapy/sd101/

                    So sorry for your husband's progression, Amanda. Wishing you both well. Celeste

                      • September 20, 2016 at 9:20 am
                      Amanda
                      Participant
                        Thanks for the info celest!! And Anna he has Mets in lungs liver adrenal gland and chest wall and now two new tumors in each thigh. He initially had tumor shrinkage and then stabilized for a few years while continuing to get the treatment. He was part of the clinical trial so he basically got to keep getting it as long as he was responding.

                        He had a pnumonia quite a few times and the last time he was in hospital for 13 days from pnumonia turned sepsis. When he was discharged we realized he had the new tumors on the thigh. Hopefully this combo will boost the immune system back up to fight this beast. I will keep you all updated on his results.

                        Amanda

                        • September 20, 2016 at 9:20 am
                        Amanda
                        Participant
                          Thanks for the info celest!! And Anna he has Mets in lungs liver adrenal gland and chest wall and now two new tumors in each thigh. He initially had tumor shrinkage and then stabilized for a few years while continuing to get the treatment. He was part of the clinical trial so he basically got to keep getting it as long as he was responding.

                          He had a pnumonia quite a few times and the last time he was in hospital for 13 days from pnumonia turned sepsis. When he was discharged we realized he had the new tumors on the thigh. Hopefully this combo will boost the immune system back up to fight this beast. I will keep you all updated on his results.

                          Amanda

                          • September 20, 2016 at 9:20 am
                          Amanda
                          Participant
                            Thanks for the info celest!! And Anna he has Mets in lungs liver adrenal gland and chest wall and now two new tumors in each thigh. He initially had tumor shrinkage and then stabilized for a few years while continuing to get the treatment. He was part of the clinical trial so he basically got to keep getting it as long as he was responding.

                            He had a pnumonia quite a few times and the last time he was in hospital for 13 days from pnumonia turned sepsis. When he was discharged we realized he had the new tumors on the thigh. Hopefully this combo will boost the immune system back up to fight this beast. I will keep you all updated on his results.

                            Amanda

                          • October 14, 2016 at 2:54 am
                          BrianP
                          Participant

                            Phase I results of SD-101 and Pembro.

                            5 patients:  1 CR, 2 PR, 1 SD, and one PD

                            Not bad.  4mg and 8mg SD-101 results to be released soon.

                            With these results would expect to see phase III trials in the not too distant future.

                            http://files.shareholder.com/downloads/DVAX/3014148471x0x911159/45AA888C-C1E1-4E3C-8736-384566F88201/RibasA_et_al_1067P_ESMO_2016_Poster.pdf

                             

                            Brian

                            • October 14, 2016 at 2:54 am
                            BrianP
                            Participant

                              Phase I results of SD-101 and Pembro.

                              5 patients:  1 CR, 2 PR, 1 SD, and one PD

                              Not bad.  4mg and 8mg SD-101 results to be released soon.

                              With these results would expect to see phase III trials in the not too distant future.

                              http://files.shareholder.com/downloads/DVAX/3014148471x0x911159/45AA888C-C1E1-4E3C-8736-384566F88201/RibasA_et_al_1067P_ESMO_2016_Poster.pdf

                               

                              Brian

                              • October 14, 2016 at 2:54 am
                              BrianP
                              Participant

                                Phase I results of SD-101 and Pembro.

                                5 patients:  1 CR, 2 PR, 1 SD, and one PD

                                Not bad.  4mg and 8mg SD-101 results to be released soon.

                                With these results would expect to see phase III trials in the not too distant future.

                                http://files.shareholder.com/downloads/DVAX/3014148471x0x911159/45AA888C-C1E1-4E3C-8736-384566F88201/RibasA_et_al_1067P_ESMO_2016_Poster.pdf

                                 

                                Brian

                            Viewing 8 reply threads
                            • You must be logged in to reply to this topic.
                            About the MRF Patient Forum

                            The MRF Patient Forum is the oldest and largest online community of people affected by melanoma. It is designed to provide peer support and information to caregivers, patients, family and friends. There is no better place to discuss different parts of your journey with this cancer and find the friends and support resources to make that journey more bearable.

                            The information on the forum is open and accessible to everyone. To add a new topic or to post a reply, you must be a registered user. Please note that you will be able to post both topics and replies anonymously even though you are logged in. All posts must abide by MRF posting policies.

                            Popular Topics