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Opdivo to Ippy/Opdivo
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Opdivo to Ippy/Opdivo

› Forums › General Melanoma Community › Opdivo to Ippy/Opdivo

  • Post
    • January 3, 2017 at 1:38 pm
    Coneflowers
    Participant
      Hello,

      I have not posted here for awhile, or really to much. I am wondering if anyone has moved on to Ippy/Opdivo combo, after being on just Opdivo with or without stable results? My daughter has been stable with just the Opdivo. She has been on it for over a year now. She has scans soon, so we will know if this has changed.

      It seems after talking with 3 other well know hospital’s…that they all have a different opinion. Which does not make already difficult decisions any easier.

      Thank you

    Viewing 5 reply threads
    • Replies
        • January 3, 2017 at 4:53 pm
        debwray
        Participant

          Hi,

          There is much research going into finding the optimum doseage for the immunotherapy drugs and also the most  beneficial order for the patients to use the drugs- including asadjuvant stage 3 or at stage 4.

          You might be interested in this research paper-   http://meetinglibrary.asco.org/content/164489-176

          My take away from the coclusions is that  nivo first then ipi gave better results than the other way around on average. slide show here http://www.slideshare.net/OSUCCCJames/melanoma-asco-review-update-2016  have a look at slide 45 and 46.

          It is a trade off as the combo is likely to give more side effects – but hasa higher probability of kicking the melanoma into the long grass. The hospitals different opinions are probably as the jury is still out BUT if your daughter is being treated in a specialist centre then the experience of the docs with the side effects is likely to make them better at recognising problems earlier and intervening appropriately to minimise impact. I suspect the answers in the end will be different for subsets of patients- depending on factors like if BRAF positive, if LDH normal,  if patients tumours express higher amounts of PD1 proteins, general health status/existence of other conditions like rheumatoid arthritis etc The researchers are trying hard to find biomarkers that will indicate likely responses- 

          Will cross my fingers that your daughters scans remain stable or better . I am two doses in to the combo but currently on hold due to dodgy liver blood work but three weeks of steroids seem to be doing the trick.

          Best of luck for your daughters treatment

          Deb

           

           

            • January 3, 2017 at 4:54 pm
            debwray
            Participant

              oops- sorry for all the typos. Really ought to proof read before posting.

              Deb

              • January 3, 2017 at 4:54 pm
              debwray
              Participant

                oops- sorry for all the typos. Really ought to proof read before posting.

                Deb

                • January 3, 2017 at 4:54 pm
                debwray
                Participant

                  oops- sorry for all the typos. Really ought to proof read before posting.

                  Deb

                  • January 21, 2017 at 8:37 am
                  Coneflowers
                  Participant
                    Deb, thank you so very much for your reply!! My daughter’s scans are stable!! Big relief! One of our biggest challenges is that she is so very young. So she can not tell us things. Thankfully she has done well in the Opdivo. Hope you can get back to treatment soon, and you have amazing results!! Take care!!
                    • January 21, 2017 at 8:37 am
                    Coneflowers
                    Participant
                      Deb, thank you so very much for your reply!! My daughter’s scans are stable!! Big relief! One of our biggest challenges is that she is so very young. So she can not tell us things. Thankfully she has done well in the Opdivo. Hope you can get back to treatment soon, and you have amazing results!! Take care!!
                      • January 21, 2017 at 8:37 am
                      Coneflowers
                      Participant
                        Deb, thank you so very much for your reply!! My daughter’s scans are stable!! Big relief! One of our biggest challenges is that she is so very young. So she can not tell us things. Thankfully she has done well in the Opdivo. Hope you can get back to treatment soon, and you have amazing results!! Take care!!
                      • January 3, 2017 at 4:53 pm
                      debwray
                      Participant

                        Hi,

                        There is much research going into finding the optimum doseage for the immunotherapy drugs and also the most  beneficial order for the patients to use the drugs- including asadjuvant stage 3 or at stage 4.

                        You might be interested in this research paper-   http://meetinglibrary.asco.org/content/164489-176

                        My take away from the coclusions is that  nivo first then ipi gave better results than the other way around on average. slide show here http://www.slideshare.net/OSUCCCJames/melanoma-asco-review-update-2016  have a look at slide 45 and 46.

                        It is a trade off as the combo is likely to give more side effects – but hasa higher probability of kicking the melanoma into the long grass. The hospitals different opinions are probably as the jury is still out BUT if your daughter is being treated in a specialist centre then the experience of the docs with the side effects is likely to make them better at recognising problems earlier and intervening appropriately to minimise impact. I suspect the answers in the end will be different for subsets of patients- depending on factors like if BRAF positive, if LDH normal,  if patients tumours express higher amounts of PD1 proteins, general health status/existence of other conditions like rheumatoid arthritis etc The researchers are trying hard to find biomarkers that will indicate likely responses- 

                        Will cross my fingers that your daughters scans remain stable or better . I am two doses in to the combo but currently on hold due to dodgy liver blood work but three weeks of steroids seem to be doing the trick.

                        Best of luck for your daughters treatment

                        Deb

                         

                         

                        • January 3, 2017 at 4:53 pm
                        debwray
                        Participant

                          Hi,

                          There is much research going into finding the optimum doseage for the immunotherapy drugs and also the most  beneficial order for the patients to use the drugs- including asadjuvant stage 3 or at stage 4.

                          You might be interested in this research paper-   http://meetinglibrary.asco.org/content/164489-176

                          My take away from the coclusions is that  nivo first then ipi gave better results than the other way around on average. slide show here http://www.slideshare.net/OSUCCCJames/melanoma-asco-review-update-2016  have a look at slide 45 and 46.

                          It is a trade off as the combo is likely to give more side effects – but hasa higher probability of kicking the melanoma into the long grass. The hospitals different opinions are probably as the jury is still out BUT if your daughter is being treated in a specialist centre then the experience of the docs with the side effects is likely to make them better at recognising problems earlier and intervening appropriately to minimise impact. I suspect the answers in the end will be different for subsets of patients- depending on factors like if BRAF positive, if LDH normal,  if patients tumours express higher amounts of PD1 proteins, general health status/existence of other conditions like rheumatoid arthritis etc The researchers are trying hard to find biomarkers that will indicate likely responses- 

                          Will cross my fingers that your daughters scans remain stable or better . I am two doses in to the combo but currently on hold due to dodgy liver blood work but three weeks of steroids seem to be doing the trick.

                          Best of luck for your daughters treatment

                          Deb

                           

                           

                          • January 4, 2017 at 9:24 pm
                          Mat
                          Participant

                            I moved to ipi-nivo after failing pembro, so yes folks do it.

                              • January 21, 2017 at 8:41 am
                              Coneflowers
                              Participant
                                Thank you for your reply Mat ☺ Did you have a response to the combo? Take care!
                                • January 21, 2017 at 8:41 am
                                Coneflowers
                                Participant
                                  Thank you for your reply Mat ☺ Did you have a response to the combo? Take care!
                                  • January 21, 2017 at 8:41 am
                                  Coneflowers
                                  Participant
                                    Thank you for your reply Mat ☺ Did you have a response to the combo? Take care!
                                  • January 4, 2017 at 9:24 pm
                                  Mat
                                  Participant

                                    I moved to ipi-nivo after failing pembro, so yes folks do it.

                                    • January 4, 2017 at 9:24 pm
                                    Mat
                                    Participant

                                      I moved to ipi-nivo after failing pembro, so yes folks do it.

                                  Viewing 5 reply threads
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