ipi/nivo combo, now BRAF
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ipi/nivo combo, now BRAF

› Forums › General Melanoma Community › ipi/nivo combo, now BRAF

  • Post
    • July 19, 2017 at 11:58 pm
    ImMark
    Participant

      Hi everyone,

      September 2016 I completed 3/4 ipi/nivo infusions for stage IV melanoma. But had to stop as toxicity became too much.

      Following treatment I had my lymph nodes removed as they had reduced but still had Melanoma present.

      Fast forward to yesterday and I received the results from an MRI which showed an 8cm tumour in my pelvis. My Oncologist now has me starting on BRAF as I tested positive for the BRAF gene.

      I was sad that the ipi/nivo combo hadnt worked as well as I had hoped. But my Dr told me that it is still an option for me down the track as I had a response.

      Has anyone gone to BRAF following a response to the ipi/nivo combination treatment?

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    • Replies
        • July 20, 2017 at 8:25 am
        Sharon93065
        Participant

          what do you mean toxicity too much?  What happend?  I get my 3rd next week.  Is it lymph node in pelvis?

            • July 21, 2017 at 12:03 am
            ImMark
            Participant

              My live rinflammation levels were too high, so I had to stop.

              It was found in the muscle of my pelvis, not the lymph node.

              • July 21, 2017 at 3:18 pm
              Sharon93065
              Participant

                Thank you for taking the time to reply.  My bloodwork yesterday showed a spike is ALT and AST and i had a panic attack last night.  But in reading others posts it wasn't that high???. ALT 95 and AST 45. I see Dr Mon for 3rd treatment next week.

              • July 20, 2017 at 10:51 pm
              J.bun
              Participant

                ImMark – While I only had 1 ipi/nivo infusion, I did take BRAF aftewards (first Zelboraf/Cotellic – then Tafinlar/Mekinist) and had excellent results.  I was allergic to the Zel combo, which is why I switched.

                Are they discussing the possibility for Keytruda too?

                  • July 21, 2017 at 12:04 am
                  ImMark
                  Participant

                    Thats great J.bun. Glad to hear you got excellent results.

                    We haven't disucssed Keyruda yet. But its on a list of options if this fails me.

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