TVEC questions

Hi Bradley, I am not sure if anyone that is a current member on the MRF forum has experience with t-vec, that being said,may be someone will post. On another melanoma site there is a guy that is very active from Texas and he is doing great after having T-vec + Pembro and I am sure he would respond to any request of information. You can look him up on "Melanoma support melanomies united" you have to join the closed facebook group or you can try reaching out to him on facebook. His name is Kent Gilliam and there is a picture of him on his bike with an American flag in the background on his facebook page. Best Wishes!!!Ed 

Hi Brad, 

I am sorry you are going through this, but super glad that this is where the science has come for you.  

Here is a link to T-VEC/talimogene laherparepvec/Imlygic information page:  https://www.imlygic.com/  

Which states:  

The IMLYGIC® virus can spread to other areas of your body or to your close contacts (household members, caregivers, sex partners, or persons sharing the same bed). Do the following to avoid spreading IMLYGIC® to other areas of your body or to your close contacts. You should share this information with them:

Avoid direct contact between your treatment sites, dressings, or body fluids and close contacts (for example, use condoms when engaging in sexual activity, avoid kissing close contacts if either of you has an open mouth sore).
Don’t touch or scratch the parts of your body that have been injected with IMLYGIC®.
Wear gloves while putting on or changing your dressings.
Keep treatment sites covered with airtight and watertight dressings for at least 1 week after each treatment (or longer if the treatment site is weeping or oozing).
Replace dressings right away with a clean dressing if they become loose or come off.
Place all used dressings and cleaning materials in a sealed plastic bag, and throw them away in the garbage.  

I have not taken this treatment personally, but here is a great deal of information on T-VEC:

https://chaoticallypreciselifeloveandmelanoma.blogspot.com/search?q=t-vec  

Here is a great deal of info on intralesionals generally:  

https://chaoticallypreciselifeloveandmelanoma.blogspot.com/search?q=intralesional&max-results=20&by-date=true  

Hopefully others with more direct experience will respond.  However, you may look up TexMelanomamex's posts as he is taking pembro with PV-10.  Hope that helps.  I wish you my best.  Celeste

I start Tvec injections tomorrow Dec. 6th. I am currently on Nivo and my disease burden is low. Just a few pencil size marks on my foot and one small sub q. I ahve also been through many steps to finally be staring.  Ed is right about Melahomies on Facebook. Many on that site have had a positive experience with Tvec. I believe the chance of developing actual herpes or passing it, is very rare. Hopefully I can also share a positive experience soon.

Hi Brad,

I have had t-vec in a nodal lesion and unfortunately it did not work for me.  The tumor got rather big during the t-vec injections and we were hoping it was working and eventually start shrinking.  Unfortunately it continued to get bigger.  I was getting pembro at the same time.   I had to switch over to a b-raf inhibitor and that shrunk the nodal lesion almost immediately.  I have not had any symptoms of herpes.  I wish you the best of luck.  I have heard others have had a more positive experience.  

T-vec was very doable. Someone recommended I take Claritin D before injections and a few days after to lessen aches and pains. It worked for me. I had some fatigue too, but nothing major. Good luck!