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Ipi and nivo study questions

This topic has 2 replies, 2 voices, and was last updated 5 years, 5 months ago by tkoss.

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- April 1, 2020 at 5:17 am
- Quote
Coopshow
Participant
My wife started the opdivo with yervoy trial infusions yesterday. Seemed to go well. I brought her home today and checked her temp randomly. She has spiked a 103.1. I got ut down with Tylenol and of course called the doctors for advice. Simply to watch it over night and if it returns to head to the er which is normal response to that fever. My question is this. Of the people out there who have had this combo have any of you had this sort of reaction so quickly? Is this a common reaction? Yervoy says that a fever can happen but nothing ive found online has mentioned it with opdivo. Im just extremely worried that something is very wrong. She says she feels fine which is crazy in my mind for a fever so high. I am just reaching out to see if anyone else has had this experience or jf this is really a rare occurrence that I should be more concerned with. Thank you in advance for any words of experience.

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- - April 1, 2020 at 5:37 am
  - Quote
  JudiAU
  Participant
  Yes, people do spike fevers on these drugs both as occasional uncomfortable ones for short periods and the more I sense, needed more care kind. I developed a sustained high fever and ended up hospitalized for five days. It was crazy. I was getting reading of 107 by trained nurses on their equipment. Many times. They used ice packs and various drugs. I ended up needing high doses of fever reduced round the clock and finally they broke it. I started taking a steroid then. This was all after the second combo. They did a lot of scans, decided to excise my brain met, and within three weeks I was back on the combo. I had all fourcombos, and about four single dose now. Other than about two months I’d mild diarrhea , which has mostly resolved, I’ve had very few side effects. Just enough to hope it is working.
  
  Read the side effect brochures again and again.
- - April 1, 2020 at 2:43 pm
  - Quote
  tkoss
  Participant
  i am on nivo monotherapy. i took aspirin for the usual aches and pains. then i had to have a mole excised and Derm insist i don’t take aspirin so i switched to Tylenol. Blood thinning issue.
  
  with a week of daily does Tylenol my liver enzymes spiked and i was refused next infusion. went without pain killer last 2 weeks, i have blood test in a hour so we shall she if Tylenol causes spike in liver enzymes.

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