Brain met year after braf/mek how to choose immuno
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Brain met year after braf/mek how to choose immuno

› Forums › General Melanoma Community › Brain met year after braf/mek how to choose immuno

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    • December 19, 2020 at 2:46 pm
    jend013
    Participant
      Hello, my husband has posted here before, but I am new.   He may see this 🙂

      Background: 37 years old. Surgery for melanoma in parotid gland summer of 2018.   One positive lymph node.  Braf/mek inhibitor from August 2018-August 2019.   NED from surgery until now.

      Brain MRI showed a single 2cm spot in his brain.   CT was clear.

      Radiation started yesterday.

      Treatment will start soon. The options we have been discussing have been the ipi/nivo combo, nivo alone, or nktr-214 trial.   I was under the impression that we were dealing with maybe a 50% response rate, to 20%, to 50% based on the trials.  I have read all of Bubble’s posts about the combo, combining immunotherapy with radation, etc.  He was weighing effectiveness vs side effects.  Seemed we were on the right track.  THEN I ran across something last night that said in the ABC trial, when patients were stratified by prior braf/mek, the response rate dropped to like 16%.  Shit.

      How do we choose?  Would we have access to any of the biomarkers to help?  Do you think the fact that he quit braf/mek 1.5 years ago makes a difference?   Has anyone one here had a good response to immunotherapy after targeted?  Am I missing something?  Is this a crapshoot?

       

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