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Hormones (low estrogen) after IPI

Forums General Melanoma Community Hormones (low estrogen) after IPI

  • Post
    pbnjelley
    Participant

      Hi!  This is the first time I've ever posted anything really, but really would like to see if anyone else is in a similar boat.   I'm 26 years old and was diagnosed this summer from a mole on my upper back and then during surgery they also took out 16 lymphy nodes under my arm, 3 of those having melanoma.  So I was a stage 3.  Through the various scans (some even done twice) my oncologist was able to tell me that I am at this point cancer free!  So I am signed up for the IPI trial to hopefully prevent any reoccurance.  I had my first transfusion th

      Hi!  This is the first time I've ever posted anything really, but really would like to see if anyone else is in a similar boat.   I'm 26 years old and was diagnosed this summer from a mole on my upper back and then during surgery they also took out 16 lymphy nodes under my arm, 3 of those having melanoma.  So I was a stage 3.  Through the various scans (some even done twice) my oncologist was able to tell me that I am at this point cancer free!  So I am signed up for the IPI trial to hopefully prevent any reoccurance.  I had my first transfusion the beginning of November and felt fine for a couple weeks with little to no side effects.  And then my body crashed a couple days before my period.   I became extremely sick (nausea, vomiting, etc) and therefore dehydrated.  I was exhausted and all my muscles ached.  I had hot flashes and night sweats and chills that nearly made life stand still as I cuddled with my heating pad, rice bag and cups of hot tea complete with down-comforter.  And then a day or two after my period, all the symptoms slowly backed off.  My oncologist (who suspected something wrong with either my adrenal gland or thyroid) made an appt with an endocrinologist who determined that my estrogen levels were alarmingly low and my body thought it was going through menopause.  Has anyone else had their hormone levels change since on IPI?  My body just did the same ordeal all over again last week (again, within the time frame of a couple days before, all through, and a couple days after my period).  So far the fix is to try being on a birth control pill to help stabalize my hormones but I am not too keen on this quick fix because I also have Factor V Liden and have to be super aware of blood clots.  I just am wondering if anyone else has experienced anything like this.  Other things that have happened since I started treatment,  i developed a pilonidal cyst (cyst on my tailbone that progressed very quickly) and pnemonia in my right lung.  I doubt these have anything to do with treatment, but will throw them out there just in case anyone else has had problems.  I'm the only person being treated with this clinical trial in the area that I live (2nd one ever to be treated) and am finding it hard to find ANYONE in the area who has any kind of melanoma knowledge whatsoever.  I find myself in the dark a lot.

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    • Replies
        FormerCaregiver
        Participant

          Welcome to our forum. Although ipi (Yervoy) is a very valuable new drug, some people
          have significant problems with it. From: http://www.yervoy.com/patient/side-effects.aspx
          "Serious side effects may include … inflammation of hormone glands (especially the
          pituitary, adrenal, and thyroid glands) that may affect how these glands work."

          Therefore, you may need to look at having a reduced dosage. Perhaps it would also be
          wise to reconsider the risks against the potential beneficial effects of Yervoy? In any
          case, I feel that you should consult your oncologist again and/or seek the opinion of a
          melanoma specialist who has more experience with treating patients with Yervoy.

          Hope this helps

          Frank from Australia

          FormerCaregiver
          Participant

            Welcome to our forum. Although ipi (Yervoy) is a very valuable new drug, some people
            have significant problems with it. From: http://www.yervoy.com/patient/side-effects.aspx
            "Serious side effects may include … inflammation of hormone glands (especially the
            pituitary, adrenal, and thyroid glands) that may affect how these glands work."

            Therefore, you may need to look at having a reduced dosage. Perhaps it would also be
            wise to reconsider the risks against the potential beneficial effects of Yervoy? In any
            case, I feel that you should consult your oncologist again and/or seek the opinion of a
            melanoma specialist who has more experience with treating patients with Yervoy.

            Hope this helps

            Frank from Australia

            FormerCaregiver
            Participant

              Welcome to our forum. Although ipi (Yervoy) is a very valuable new drug, some people
              have significant problems with it. From: http://www.yervoy.com/patient/side-effects.aspx
              "Serious side effects may include … inflammation of hormone glands (especially the
              pituitary, adrenal, and thyroid glands) that may affect how these glands work."

              Therefore, you may need to look at having a reduced dosage. Perhaps it would also be
              wise to reconsider the risks against the potential beneficial effects of Yervoy? In any
              case, I feel that you should consult your oncologist again and/or seek the opinion of a
              melanoma specialist who has more experience with treating patients with Yervoy.

              Hope this helps

              Frank from Australia

          Viewing 2 reply threads
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