Can anyone in the Melanoma Land interpret this for me?

It looks to me like they have discovered WHY melanoma is resistant to chemo, but now they have to figure out how to get around it. 

 It was hard for me to read because currently, my husband is responding extremely well to a combination of carboplatin and taxol and I'm wondering if it will last. His tumors were growing at a very alarming rate, visibly growing fast daily, and after the first treatment of chemo, they shrank just as fast.  The chemo was originally planned to be used only as a "band aid" treatment until he could use something else because of the rapid growth.  Now they are saying that there is a chance that this will have some sort of lasting response in him.  They don't usually see such a good response with chemo.  A lot of prayers are being said and God is good, so maybe for my husband, this will work.

If only they could unlock the puzzle fast enough………………for everyone.

It looks to me like they have discovered WHY melanoma is resistant to chemo, but now they have to figure out how to get around it. 

 It was hard for me to read because currently, my husband is responding extremely well to a combination of carboplatin and taxol and I'm wondering if it will last. His tumors were growing at a very alarming rate, visibly growing fast daily, and after the first treatment of chemo, they shrank just as fast.  The chemo was originally planned to be used only as a "band aid" treatment until he could use something else because of the rapid growth.  Now they are saying that there is a chance that this will have some sort of lasting response in him.  They don't usually see such a good response with chemo.  A lot of prayers are being said and God is good, so maybe for my husband, this will work.

If only they could unlock the puzzle fast enough………………for everyone.

It looks to me like they have discovered WHY melanoma is resistant to chemo, but now they have to figure out how to get around it. 

 It was hard for me to read because currently, my husband is responding extremely well to a combination of carboplatin and taxol and I'm wondering if it will last. His tumors were growing at a very alarming rate, visibly growing fast daily, and after the first treatment of chemo, they shrank just as fast.  The chemo was originally planned to be used only as a "band aid" treatment until he could use something else because of the rapid growth.  Now they are saying that there is a chance that this will have some sort of lasting response in him.  They don't usually see such a good response with chemo.  A lot of prayers are being said and God is good, so maybe for my husband, this will work.

If only they could unlock the puzzle fast enough………………for everyone.

It means they have figured out two of the pathways that melanoma cells use to resist chemotherapy. I have a feeling there are more pathways so even if a way is found around these two pathways to help make chemo work better, I suspect the melanoma will just use another pathway instead as it eventually does in other therapies such as those that are BRAF positive.

Eventually, a combo drug will be created that will hopefully block many of the pathways including the ones melanoma uses for growth.

It means they have figured out two of the pathways that melanoma cells use to resist chemotherapy. I have a feeling there are more pathways so even if a way is found around these two pathways to help make chemo work better, I suspect the melanoma will just use another pathway instead as it eventually does in other therapies such as those that are BRAF positive.

Eventually, a combo drug will be created that will hopefully block many of the pathways including the ones melanoma uses for growth.

It means they have figured out two of the pathways that melanoma cells use to resist chemotherapy. I have a feeling there are more pathways so even if a way is found around these two pathways to help make chemo work better, I suspect the melanoma will just use another pathway instead as it eventually does in other therapies such as those that are BRAF positive.

Eventually, a combo drug will be created that will hopefully block many of the pathways including the ones melanoma uses for growth.

You would think with all the smart people in the world someone would figure out how to cure cancer for real…like more than just treat it with chemo, etc.

This article really is saying maybe in a million years melanoma can be treated with the current cancer therapies which still aren't always so great (just better than current available therapy for Mel). 

You would think with all the smart people in the world someone would figure out how to cure cancer for real…like more than just treat it with chemo, etc.

This article really is saying maybe in a million years melanoma can be treated with the current cancer therapies which still aren't always so great (just better than current available therapy for Mel). 

You would think with all the smart people in the world someone would figure out how to cure cancer for real…like more than just treat it with chemo, etc.

This article really is saying maybe in a million years melanoma can be treated with the current cancer therapies which still aren't always so great (just better than current available therapy for Mel).