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From Bristol-Myers Squibb: Yervoy Four and Five Year Survival Data
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From Bristol-Myers Squibb: Yervoy Four and Five Year Survival Data

› Forums › General Melanoma Community › From Bristol-Myers Squibb: Yervoy Four and Five Year Survival Data

  • Post
    • October 2, 2012 at 4:40 am
    emichaelward
    Participant

      Anybody else see the press release yesterday from Bristol-Myers Squibb about four and five year survival rates of Yervoy patients in several different trials? (see http://www.bsm.com, select news, and then press releases.) Here are the headline bullets:

      Anybody else see the press release yesterday from Bristol-Myers Squibb about four and five year survival rates of Yervoy patients in several different trials? (see http://www.bsm.com, select news, and then press releases.) Here are the headline bullets:

      • Long-Term Follow Up From Phase 3 Study (024) Demonstrated That 19.0 Percent of Treatment-Naïve Patients Who Received YERVOY at Investigational Dose of 10 mg/kg Plus Dacarbazine (DTIC) Were Alive at Four Years vs. 9.6 Percent of Patients Treated with DTIC Alone
      • Few New Immune-Related Adverse Events Occurred Beyond Two Years of Treatment in Study 024
      • Five-Year Follow Up from Three Exploratory Phase 2 Trials Add to Growing Body of Survival Data for YERVOY in Metastatic Melanoma
      • In Both Analyses, Updated Survival Rates Remained Relatively Stable Over Time                                                                                                                                                                                                                                             

      But it was the details of that reports that had some remarkable statistics. Here's one taken out of context from the results of 3 phase II trials (there were varying dosages of Yervoy among other things) so read the article:

      “In treatment-naïve patients, the five-year estimated survival rates ranged from 38% to 49%, which was unchanged from the four-year rates.”

      I don't try and interpret clinical study data because there are so many variables it hard for me to make a decisive conclusions(and I'm a scientist) but these claims sure sounds good.

      I was diagnosed with stage IV melanoma about a year ago. After I finished my Yervoy infusions (3 mg/kg) six months ago, I have had reductions or stable tumors in all three subsequent scans (Thank You God!). But I'm having trouble finding current information on how long this this might continue. I know we all are different but would like to hear about longtime (greater than a year) survivors.

      Thanks,

      Mike

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    • Replies
        • October 20, 2012 at 2:16 am
        Jim M.
        Participant

          Hi Mike,

           Hope you still check this post. I'm stage 3C and am almost 5years NED since surgery (LND). I was on Yervoy (Ipi) 10mg/kg from 3/08 to 11/08. I also received peptide vaccines. I had to stop the trial due to swelling of the pituitary gland. This Nov. I'm a 4 year survivor since Yervoy. My dr. in Tampa told me half of the participants of the trial I was on are still alive. I didn't ask him how many total participants were on the trial.

           God Bless you,

           Jim M.

          • October 20, 2012 at 2:16 am
          Jim M.
          Participant

            Hi Mike,

             Hope you still check this post. I'm stage 3C and am almost 5years NED since surgery (LND). I was on Yervoy (Ipi) 10mg/kg from 3/08 to 11/08. I also received peptide vaccines. I had to stop the trial due to swelling of the pituitary gland. This Nov. I'm a 4 year survivor since Yervoy. My dr. in Tampa told me half of the participants of the trial I was on are still alive. I didn't ask him how many total participants were on the trial.

             God Bless you,

             Jim M.

            • October 20, 2012 at 2:16 am
            Jim M.
            Participant

              Hi Mike,

               Hope you still check this post. I'm stage 3C and am almost 5years NED since surgery (LND). I was on Yervoy (Ipi) 10mg/kg from 3/08 to 11/08. I also received peptide vaccines. I had to stop the trial due to swelling of the pituitary gland. This Nov. I'm a 4 year survivor since Yervoy. My dr. in Tampa told me half of the participants of the trial I was on are still alive. I didn't ask him how many total participants were on the trial.

               God Bless you,

               Jim M.

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