zelboraf vs yervoy
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zelboraf vs yervoy

› Forums › General Melanoma Community › zelboraf vs yervoy

  • Post
    • November 17, 2012 at 9:39 pm
    doriniel
    Participant

      Has anyone stopped taking zelboraf and switched to yervoy with good results? wondering if that would be a good idea and keep zelboraf for back up if yervoy fails.

      Has anyone stopped taking zelboraf and switched to yervoy with good results? wondering if that would be a good idea and keep zelboraf for back up if yervoy fails.

    Viewing 11 reply threads
    • Replies
        • November 18, 2012 at 1:33 am
        awillett1991
        Participant
          I’m in the midst of this and it hasn’t gone smoothly. I’m still convinced this is my best long term shot since I will not qualify for any trial, anywhere bc of heart tumor. The issue is not will Ipi fail, but will it have time to work while disease is certainly progressing. Ipi is not a fast acting therapy.

          I’ve updated my profile with the details.

          • November 18, 2012 at 1:33 am
          awillett1991
          Participant
            I’m in the midst of this and it hasn’t gone smoothly. I’m still convinced this is my best long term shot since I will not qualify for any trial, anywhere bc of heart tumor. The issue is not will Ipi fail, but will it have time to work while disease is certainly progressing. Ipi is not a fast acting therapy.

            I’ve updated my profile with the details.

            • November 18, 2012 at 1:33 am
            awillett1991
            Participant
              I’m in the midst of this and it hasn’t gone smoothly. I’m still convinced this is my best long term shot since I will not qualify for any trial, anywhere bc of heart tumor. The issue is not will Ipi fail, but will it have time to work while disease is certainly progressing. Ipi is not a fast acting therapy.

              I’ve updated my profile with the details.

              • November 19, 2012 at 10:05 am
              JerryfromFauq
              Participant

                Zelborf (fast acting) is more often being recommended as being used as a near term effort to reduce tumor load so that something else (like slower acting Yervoy) can have a chance to become effective.  The odds on having a short term positive response is highest with Zelboraf.  The odds on having a long term response is higher with Yervoy.  They are both so new that more is being learned in this area monthly.  

                  My personal theory is"Why stop something that is working by at least reducing ones tumor load to jump to something else that I don't even know if will provide any positive benefit and is likely to cause greater negative side effects."

                • November 19, 2012 at 10:05 am
                JerryfromFauq
                Participant

                  Zelborf (fast acting) is more often being recommended as being used as a near term effort to reduce tumor load so that something else (like slower acting Yervoy) can have a chance to become effective.  The odds on having a short term positive response is highest with Zelboraf.  The odds on having a long term response is higher with Yervoy.  They are both so new that more is being learned in this area monthly.  

                    My personal theory is"Why stop something that is working by at least reducing ones tumor load to jump to something else that I don't even know if will provide any positive benefit and is likely to cause greater negative side effects."

                    • November 20, 2012 at 9:44 pm
                    awillett1991
                    Participant
                      Very good point you make Jerry, everyone has their own journey and decisions to make. I think there is still much to learn about these new therapies and a lot of experimentation going on concerning how and when to best use them.
                      • November 20, 2012 at 9:44 pm
                      awillett1991
                      Participant
                        Very good point you make Jerry, everyone has their own journey and decisions to make. I think there is still much to learn about these new therapies and a lot of experimentation going on concerning how and when to best use them.
                        • November 20, 2012 at 9:44 pm
                        awillett1991
                        Participant
                          Very good point you make Jerry, everyone has their own journey and decisions to make. I think there is still much to learn about these new therapies and a lot of experimentation going on concerning how and when to best use them.
                        • November 19, 2012 at 10:05 am
                        JerryfromFauq
                        Participant

                          Zelborf (fast acting) is more often being recommended as being used as a near term effort to reduce tumor load so that something else (like slower acting Yervoy) can have a chance to become effective.  The odds on having a short term positive response is highest with Zelboraf.  The odds on having a long term response is higher with Yervoy.  They are both so new that more is being learned in this area monthly.  

                            My personal theory is"Why stop something that is working by at least reducing ones tumor load to jump to something else that I don't even know if will provide any positive benefit and is likely to cause greater negative side effects."

                          • November 20, 2012 at 6:34 pm
                          sgrain
                          Participant
                            I think it all depends on the number and size of the tumors I started yervoy 3 weeks ago and was told that because my tumors are small and only have 3, this would be best option, keeping zelboraf as last resort. I wish you luck.
                            • November 20, 2012 at 6:34 pm
                            sgrain
                            Participant
                              I think it all depends on the number and size of the tumors I started yervoy 3 weeks ago and was told that because my tumors are small and only have 3, this would be best option, keeping zelboraf as last resort. I wish you luck.
                              • November 20, 2012 at 6:34 pm
                              sgrain
                              Participant
                                I think it all depends on the number and size of the tumors I started yervoy 3 weeks ago and was told that because my tumors are small and only have 3, this would be best option, keeping zelboraf as last resort. I wish you luck.
                                • November 20, 2012 at 6:35 pm
                                sgrain
                                Participant
                                  I think it all depends on the number and size of the tumors I started yervoy 3 weeks ago and was told that because my tumors are small and only have 3, this would be best option, keeping zelboraf as last resort. I wish you luck.
                                    • November 21, 2012 at 10:45 am
                                    JerryfromFauq
                                    Participant

                                      With a low tumor load, odds are that you have time to see if Yervoy will work.  For your case this makes sense unless you havae major colon problems which Yervoy can esculate.

                                      • November 21, 2012 at 10:45 am
                                      JerryfromFauq
                                      Participant

                                        With a low tumor load, odds are that you have time to see if Yervoy will work.  For your case this makes sense unless you havae major colon problems which Yervoy can esculate.

                                        • November 21, 2012 at 10:45 am
                                        JerryfromFauq
                                        Participant

                                          With a low tumor load, odds are that you have time to see if Yervoy will work.  For your case this makes sense unless you havae major colon problems which Yervoy can esculate.

                                        • November 20, 2012 at 6:35 pm
                                        sgrain
                                        Participant
                                          I think it all depends on the number and size of the tumors I started yervoy 3 weeks ago and was told that because my tumors are small and only have 3, this would be best option, keeping zelboraf as last resort. I wish you luck.
                                          • November 20, 2012 at 6:35 pm
                                          sgrain
                                          Participant
                                            I think it all depends on the number and size of the tumors I started yervoy 3 weeks ago and was told that because my tumors are small and only have 3, this would be best option, keeping zelboraf as last resort. I wish you luck.
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