MRF-Logo2019-Horizontal-RGB
HD IL-2 and Zelboraf trial
REGISTER
The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Content within the patient forum is user-generated and has not been reviewed by medical professionals. Other sections of the Melanoma Research Foundation website include information that has been reviewed by medical professionals as appropriate. All medical decisions should be made in consultation with your doctor or other qualified medical professional.

HD IL-2 and Zelboraf trial

› Forums › General Melanoma Community › HD IL-2 and Zelboraf trial

  • Post
    • February 4, 2014 at 2:05 am
    mark1101
    Participant

      Just approved today for the Phase 4 trial combining IL-2 and Vemurafenib in sequence.  Anyone with experience in this trial who can tell me their experiences?

    Viewing 8 reply threads
    • Replies
        • February 4, 2014 at 2:17 am
        Bubbles
        Participant

          Hey Mark,

          So glad you have a plan and have all my fingers crossed that you will have success with it.  I have no personal experience to offer, but had posted this link earlier for folks who had questions about the combo.  Perhaps it will give you some info that you could use.

          http://clincancerres.aacrjournals.org/content/19/5/1225.abstract

          I wish you my best.  Celeste

            • February 4, 2014 at 7:43 pm
            Cooper
            Participant

              That post doesnt' say anything about this trial Bubbles.  What are you referring to?

              • February 4, 2014 at 7:43 pm
              Cooper
              Participant

                That post doesnt' say anything about this trial Bubbles.  What are you referring to?

                • February 4, 2014 at 7:43 pm
                Cooper
                Participant

                  That post doesnt' say anything about this trial Bubbles.  What are you referring to?

                  • February 5, 2014 at 2:35 am
                  Bubbles
                  Participant

                    This article explains how BRAF changes the tumor so that immunologic agents can be even more effective when combined with it….like the Vemurafanib and IL2 combo that Mark is about to start.  Hope that helps.  C

                    • February 5, 2014 at 2:35 am
                    Bubbles
                    Participant

                      This article explains how BRAF changes the tumor so that immunologic agents can be even more effective when combined with it….like the Vemurafanib and IL2 combo that Mark is about to start.  Hope that helps.  C

                      • February 5, 2014 at 2:35 am
                      Bubbles
                      Participant

                        This article explains how BRAF changes the tumor so that immunologic agents can be even more effective when combined with it….like the Vemurafanib and IL2 combo that Mark is about to start.  Hope that helps.  C

                      • February 4, 2014 at 2:17 am
                      Bubbles
                      Participant

                        Hey Mark,

                        So glad you have a plan and have all my fingers crossed that you will have success with it.  I have no personal experience to offer, but had posted this link earlier for folks who had questions about the combo.  Perhaps it will give you some info that you could use.

                        http://clincancerres.aacrjournals.org/content/19/5/1225.abstract

                        I wish you my best.  Celeste

                        • February 4, 2014 at 2:17 am
                        Bubbles
                        Participant

                          Hey Mark,

                          So glad you have a plan and have all my fingers crossed that you will have success with it.  I have no personal experience to offer, but had posted this link earlier for folks who had questions about the combo.  Perhaps it will give you some info that you could use.

                          http://clincancerres.aacrjournals.org/content/19/5/1225.abstract

                          I wish you my best.  Celeste

                          • February 4, 2014 at 1:52 pm
                          Cooper
                          Participant

                            My son was supposed to do this until we looked into the toxicity of it.  He was supposed to be in intensive care for the IL2 and that sent us looking for something less scary.  We are doing the combo (taf/mek) instead.  

                            • February 4, 2014 at 1:52 pm
                            Cooper
                            Participant

                              My son was supposed to do this until we looked into the toxicity of it.  He was supposed to be in intensive care for the IL2 and that sent us looking for something less scary.  We are doing the combo (taf/mek) instead.  

                                • February 4, 2014 at 5:06 pm
                                hannahcopeland1
                                Participant

                                  I was in this trial and dropped a week before the IL-2 treatment because my family freaked out. I stayed on Zelboraf until last week and then I switched to the tafinlar/mek combo that I'm on now.

                                  Its a scary trial, but all of this is scary. It could be just the right thing for you. I often wonder if it could have been for me, but i also have to keep looking forward.

                                  I hope this trail is perfect for you! Good luck!

                                  • February 4, 2014 at 5:06 pm
                                  hannahcopeland1
                                  Participant

                                    I was in this trial and dropped a week before the IL-2 treatment because my family freaked out. I stayed on Zelboraf until last week and then I switched to the tafinlar/mek combo that I'm on now.

                                    Its a scary trial, but all of this is scary. It could be just the right thing for you. I often wonder if it could have been for me, but i also have to keep looking forward.

                                    I hope this trail is perfect for you! Good luck!

                                    • February 4, 2014 at 5:06 pm
                                    hannahcopeland1
                                    Participant

                                      I was in this trial and dropped a week before the IL-2 treatment because my family freaked out. I stayed on Zelboraf until last week and then I switched to the tafinlar/mek combo that I'm on now.

                                      Its a scary trial, but all of this is scary. It could be just the right thing for you. I often wonder if it could have been for me, but i also have to keep looking forward.

                                      I hope this trail is perfect for you! Good luck!

                                    • February 4, 2014 at 1:52 pm
                                    Cooper
                                    Participant

                                      My son was supposed to do this until we looked into the toxicity of it.  He was supposed to be in intensive care for the IL2 and that sent us looking for something less scary.  We are doing the combo (taf/mek) instead.  

                                      • February 4, 2014 at 10:36 pm
                                      JoshF
                                      Participant

                                        Mark-

                                        Is this the trial through Prometheus Labs? I just finished IL2 though I did the ipi/HD IL2 trial so I can't speak to the zel portion as I was BRAF – but the Il2 is a tough treatment but very doable. You have a few rough weeks but bounce back. I did 11 bags for the 2 rounds of IL2. I went with trial because each drug acts on different mechanism and if you respond especially to IL2…it offers durable response. I'm basically back to 100% and I've been out of hospital just over week now. I have scans in 2 weeks.

                                        I wish you all the best in your treatment plan. Keep us updated.

                                        Josh

                                        • February 4, 2014 at 10:36 pm
                                        JoshF
                                        Participant

                                          Mark-

                                          Is this the trial through Prometheus Labs? I just finished IL2 though I did the ipi/HD IL2 trial so I can't speak to the zel portion as I was BRAF – but the Il2 is a tough treatment but very doable. You have a few rough weeks but bounce back. I did 11 bags for the 2 rounds of IL2. I went with trial because each drug acts on different mechanism and if you respond especially to IL2…it offers durable response. I'm basically back to 100% and I've been out of hospital just over week now. I have scans in 2 weeks.

                                          I wish you all the best in your treatment plan. Keep us updated.

                                          Josh

                                          • February 4, 2014 at 10:36 pm
                                          JoshF
                                          Participant

                                            Mark-

                                            Is this the trial through Prometheus Labs? I just finished IL2 though I did the ipi/HD IL2 trial so I can't speak to the zel portion as I was BRAF – but the Il2 is a tough treatment but very doable. You have a few rough weeks but bounce back. I did 11 bags for the 2 rounds of IL2. I went with trial because each drug acts on different mechanism and if you respond especially to IL2…it offers durable response. I'm basically back to 100% and I've been out of hospital just over week now. I have scans in 2 weeks.

                                            I wish you all the best in your treatment plan. Keep us updated.

                                            Josh

                                        Viewing 8 reply threads
                                        • You must be logged in to reply to this topic.
                                        About the MRF Patient Forum

                                        The MRF Patient Forum is the oldest and largest online community of people affected by melanoma. It is designed to provide peer support and information to caregivers, patients, family and friends. There is no better place to discuss different parts of your journey with this cancer and find the friends and support resources to make that journey more bearable.

                                        The information on the forum is open and accessible to everyone. To add a new topic or to post a reply, you must be a registered user. Please note that you will be able to post both topics and replies anonymously even though you are logged in. All posts must abide by MRF posting policies.

                                        Popular Topics