Ipi not working?

I really wouldn't jump to that conclusion.  I know it's tough not to think the worse with this disease.  I assume you aren't having Ipi infusions now so I wouldn't expect the side effects to continue.  That doesn't mean Ipi has lost it's effectiveness.  I really don't know exactly how Ipi seems to be durable and I'm not sure that even the real smart guys know the answer to that.  In my simple mind I picture that once Ipi allows your immune system to start getting the upper hand on the melanoma that your immune system starts to "learn" how to recognize and defeat the melanoma.  Once your immune system has cracked the code it doesn't need Ipi to fight the melanoma anymore.  The good news is that it has been shown that if the melanoma does return Ipi can work again.  I'm not the smartest guy in the room and I didn't stay at a Holiday Inn Express last night but that's what I believe.  Congrats on the NED.  Hope the thyroid issue is under control.  I had that side effect from Ipi also.

Brian

I really wouldn't jump to that conclusion.  I know it's tough not to think the worse with this disease.  I assume you aren't having Ipi infusions now so I wouldn't expect the side effects to continue.  That doesn't mean Ipi has lost it's effectiveness.  I really don't know exactly how Ipi seems to be durable and I'm not sure that even the real smart guys know the answer to that.  In my simple mind I picture that once Ipi allows your immune system to start getting the upper hand on the melanoma that your immune system starts to "learn" how to recognize and defeat the melanoma.  Once your immune system has cracked the code it doesn't need Ipi to fight the melanoma anymore.  The good news is that it has been shown that if the melanoma does return Ipi can work again.  I'm not the smartest guy in the room and I didn't stay at a Holiday Inn Express last night but that's what I believe.  Congrats on the NED.  Hope the thyroid issue is under control.  I had that side effect from Ipi also.

Brian

I really wouldn't jump to that conclusion.  I know it's tough not to think the worse with this disease.  I assume you aren't having Ipi infusions now so I wouldn't expect the side effects to continue.  That doesn't mean Ipi has lost it's effectiveness.  I really don't know exactly how Ipi seems to be durable and I'm not sure that even the real smart guys know the answer to that.  In my simple mind I picture that once Ipi allows your immune system to start getting the upper hand on the melanoma that your immune system starts to "learn" how to recognize and defeat the melanoma.  Once your immune system has cracked the code it doesn't need Ipi to fight the melanoma anymore.  The good news is that it has been shown that if the melanoma does return Ipi can work again.  I'm not the smartest guy in the room and I didn't stay at a Holiday Inn Express last night but that's what I believe.  Congrats on the NED.  Hope the thyroid issue is under control.  I had that side effect from Ipi also.

Brian

My research on the IpI is once  you stop taking the infusions the side effects will subside. that in no way indicates that the IPI is not working. IpI is meant to kick start the immunity system, bridge gaps in the immunity system, and cause some inflammation of the tumors so the immunity system will start attacking and fighting the disease on its own. Your doctor can recommend things for the thyroid. Good luck and stay strong and positive. Continue to fight and win. 

My research on the IpI is once  you stop taking the infusions the side effects will subside. that in no way indicates that the IPI is not working. IpI is meant to kick start the immunity system, bridge gaps in the immunity system, and cause some inflammation of the tumors so the immunity system will start attacking and fighting the disease on its own. Your doctor can recommend things for the thyroid. Good luck and stay strong and positive. Continue to fight and win. 

My research on the IpI is once  you stop taking the infusions the side effects will subside. that in no way indicates that the IPI is not working. IpI is meant to kick start the immunity system, bridge gaps in the immunity system, and cause some inflammation of the tumors so the immunity system will start attacking and fighting the disease on its own. Your doctor can recommend things for the thyroid. Good luck and stay strong and positive. Continue to fight and win. 

You are one of a few people I have come across on the Forum lately discussing thyroid issues after ipi.  I lived with mine for at least a couple months before a neurologist unrelated to my ipi treatments had me tested.  After discovering that my thyroid levels were all indicative of hyperthyroidism, I went to an endocrinologist who was very sceptical that this could have anything to do with my ipi treatments.  If there were a relationship, it would be hypothyrodism and not hyper.  He finally diagnosed Graves Disease and I received radioactive iodine a month ago and am waiting for more testing to see where things stand.  My symptoms were relieved by propranalol (Inderal) which I am still receiving.  Major symptoms were tremor and muscle weakness.  My pituitary is no longer producing, and the endocrinologist is not sure, it seems, whether this is related to long-term steriod use (continuing) or the Graves Disease.  In reading your post, I was wondering whether your dysfunction related to ipi was an under or overactivity of the thyroid and what you may have heard about thyroid problems following ipi or seen in your reading.  My oncologist does not doubt that my problems are likely the result of ipi but is not, of course, an endocrinologist.

You are one of a few people I have come across on the Forum lately discussing thyroid issues after ipi.  I lived with mine for at least a couple months before a neurologist unrelated to my ipi treatments had me tested.  After discovering that my thyroid levels were all indicative of hyperthyroidism, I went to an endocrinologist who was very sceptical that this could have anything to do with my ipi treatments.  If there were a relationship, it would be hypothyrodism and not hyper.  He finally diagnosed Graves Disease and I received radioactive iodine a month ago and am waiting for more testing to see where things stand.  My symptoms were relieved by propranalol (Inderal) which I am still receiving.  Major symptoms were tremor and muscle weakness.  My pituitary is no longer producing, and the endocrinologist is not sure, it seems, whether this is related to long-term steriod use (continuing) or the Graves Disease.  In reading your post, I was wondering whether your dysfunction related to ipi was an under or overactivity of the thyroid and what you may have heard about thyroid problems following ipi or seen in your reading.  My oncologist does not doubt that my problems are likely the result of ipi but is not, of course, an endocrinologist.

You are one of a few people I have come across on the Forum lately discussing thyroid issues after ipi.  I lived with mine for at least a couple months before a neurologist unrelated to my ipi treatments had me tested.  After discovering that my thyroid levels were all indicative of hyperthyroidism, I went to an endocrinologist who was very sceptical that this could have anything to do with my ipi treatments.  If there were a relationship, it would be hypothyrodism and not hyper.  He finally diagnosed Graves Disease and I received radioactive iodine a month ago and am waiting for more testing to see where things stand.  My symptoms were relieved by propranalol (Inderal) which I am still receiving.  Major symptoms were tremor and muscle weakness.  My pituitary is no longer producing, and the endocrinologist is not sure, it seems, whether this is related to long-term steriod use (continuing) or the Graves Disease.  In reading your post, I was wondering whether your dysfunction related to ipi was an under or overactivity of the thyroid and what you may have heard about thyroid problems following ipi or seen in your reading.  My oncologist does not doubt that my problems are likely the result of ipi but is not, of course, an endocrinologist.