My mother has battled stage 4 since October 2014. Successfully got WBR and taf-mek combo for 6 months, then started opdivo while continuing low dose taf for a further 6 months. During this time, when mek was onboard as well, she was hospitalized with hepatitis.
Opdivo and low dose taf worked until October 2015. Then, we added Yervoy 2 doses, stopping taf. As my mother got fluid buildups and new multiple brain mets, we restarted low dose taf and added Temodar. That also didn't work and she is now also too weak to receive more Yervoy. The only option we can think of is restarting mekinist with the thought that maybe the aggressive cancer progression in her body is using the Mek pathway, its 2nd best option after it has found a way around RAF. Due to the high toxicity of 3 treatments at once, Mekinist was dropped from her regimen 6 months before she then progressed on Taf.
Has anyone had experience progressing on taf (tried twice) and then reintroducing mek? We understand that Taf/Mek is the same pathway but a Google search of diagrams of the pathway seem to suggest that the cancer tries RAF first, then MEK, then ERK (in trials?).
Also – those who have tried Temodar, any knowledge as to a) how quickly it worked and b) how soon it is flushed out of the system? Google says halflife is 1.8 hours. Right now our last options to buy time are Temodar alone or Mekinist alone.
