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After 48 weeks on BRAF/MEK trial, the drugs no longer work. Plan B???
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After 48 weeks on BRAF/MEK trial, the drugs no longer work. Plan B???

› Forums › General Melanoma Community › After 48 weeks on BRAF/MEK trial, the drugs no longer work. Plan B???

  • Post
    • February 16, 2012 at 2:24 am
    mommydog
    Participant

      The oncologist told us today that my husband's latest PET/CT disclosed a couple of new mets and some growth in pre-exisiting mets.  This means that the drugs are no longer working for him and we are on to plan B, which we need to decide upon very soon.  The two options the doctor presented were:

       

      1. enrollment in a phase two clinical trial by MERCK on PD-1 or:

      2. treatment with Yervoy and the Roche BRAF inhibitor as a combination therapy.

       

      The doctor said if it were him, he would do the trial.

       

      The oncologist told us today that my husband's latest PET/CT disclosed a couple of new mets and some growth in pre-exisiting mets.  This means that the drugs are no longer working for him and we are on to plan B, which we need to decide upon very soon.  The two options the doctor presented were:

       

      1. enrollment in a phase two clinical trial by MERCK on PD-1 or:

      2. treatment with Yervoy and the Roche BRAF inhibitor as a combination therapy.

       

      The doctor said if it were him, he would do the trial.

       

      Does anyone have any informtion on the PD-1 trials?

       

      Thanks

      Deborah

    Viewing 11 reply threads
    • Replies
        • February 16, 2012 at 9:43 pm
        deardad
        Participant

          Im sorry to hear the inhibitors have stopped working. My dad is currently on his 5th cycle of vermurafenib and we are in that buying time period. I'm not sure what to go with next but PD-1 sounds encouraging. I can't remember her name but she was seeing Dr Weber at MD Anderson and mentioned that MDX1106 aka BMS926556 is one of the better PD-1 drugs. I'm thinking your doctor is probably correct in recommending the trial as you may always try the 2nd option as plan C.

          Take care and don't ever look back at the decision you make.

          Nahmi

          • February 16, 2012 at 9:43 pm
          deardad
          Participant

            Im sorry to hear the inhibitors have stopped working. My dad is currently on his 5th cycle of vermurafenib and we are in that buying time period. I'm not sure what to go with next but PD-1 sounds encouraging. I can't remember her name but she was seeing Dr Weber at MD Anderson and mentioned that MDX1106 aka BMS926556 is one of the better PD-1 drugs. I'm thinking your doctor is probably correct in recommending the trial as you may always try the 2nd option as plan C.

            Take care and don't ever look back at the decision you make.

            Nahmi

            • February 16, 2012 at 9:43 pm
            deardad
            Participant

              Im sorry to hear the inhibitors have stopped working. My dad is currently on his 5th cycle of vermurafenib and we are in that buying time period. I'm not sure what to go with next but PD-1 sounds encouraging. I can't remember her name but she was seeing Dr Weber at MD Anderson and mentioned that MDX1106 aka BMS926556 is one of the better PD-1 drugs. I'm thinking your doctor is probably correct in recommending the trial as you may always try the 2nd option as plan C.

              Take care and don't ever look back at the decision you make.

              Nahmi

              • February 16, 2012 at 11:11 pm
              LynnLuc
              Participant

                I am in the MDX 1106 ( anti PD-1 ) trial at Moffitt with Dr Weber. I am doing great and March 26 I will have my 2 years of NED . I am stage 4!

                • February 16, 2012 at 11:11 pm
                LynnLuc
                Participant

                  I am in the MDX 1106 ( anti PD-1 ) trial at Moffitt with Dr Weber. I am doing great and March 26 I will have my 2 years of NED . I am stage 4!

                  • February 16, 2012 at 11:11 pm
                  LynnLuc
                  Participant

                    I am in the MDX 1106 ( anti PD-1 ) trial at Moffitt with Dr Weber. I am doing great and March 26 I will have my 2 years of NED . I am stage 4!

                    • February 16, 2012 at 11:12 pm
                    MeNDave
                    Participant

                      Hi Deborah,

                      I have heard that the anti-pd1 trials are showing better results than Yervoy (up to 33% response), but that is through the grapevine.  However, I do know that some of the anti-pd1 trials will not allow prior treatment with Yervoy, so you may want to keep that in mind. 

                      Best wishes in whatever you decide,

                      Maria

                        • February 17, 2012 at 1:57 am
                        LynnLuc
                        Participant

                          I think originally they did not allow prior use of Yervoy, like in my trial ( mine was for surgically resected)…but the sister trial , which if those not NED has an arm with previous Yervoy use…now they are even combining the two ( or so I heard!)

                          • February 17, 2012 at 1:57 am
                          LynnLuc
                          Participant

                            I think originally they did not allow prior use of Yervoy, like in my trial ( mine was for surgically resected)…but the sister trial , which if those not NED has an arm with previous Yervoy use…now they are even combining the two ( or so I heard!)

                            • February 17, 2012 at 10:15 pm
                            boot2aboot
                            Participant

                               

                              You have to be HLA_A2 to be on moffitts anti-pd1tial…that leaves a lot of us out in the cold…anti PD-1, depending on the version, is about 35 % effective…that means PR and CRs…i think Yervoy is something like 15%…then there is IL2…5% and Adoptive  Cell Transfer which is rough and tough that includes IL2…numbers are good though something around 30-40% PRs…i would look at Adoptive Cell Transfer and older versions of anti PD1/PDLs…if anti PD1 works, it will do so very fast…or not at all….

                              boots

                              • February 17, 2012 at 10:15 pm
                              boot2aboot
                              Participant

                                 

                                You have to be HLA_A2 to be on moffitts anti-pd1tial…that leaves a lot of us out in the cold…anti PD-1, depending on the version, is about 35 % effective…that means PR and CRs…i think Yervoy is something like 15%…then there is IL2…5% and Adoptive  Cell Transfer which is rough and tough that includes IL2…numbers are good though something around 30-40% PRs…i would look at Adoptive Cell Transfer and older versions of anti PD1/PDLs…if anti PD1 works, it will do so very fast…or not at all….

                                boots

                                • February 17, 2012 at 10:15 pm
                                boot2aboot
                                Participant

                                   

                                  You have to be HLA_A2 to be on moffitts anti-pd1tial…that leaves a lot of us out in the cold…anti PD-1, depending on the version, is about 35 % effective…that means PR and CRs…i think Yervoy is something like 15%…then there is IL2…5% and Adoptive  Cell Transfer which is rough and tough that includes IL2…numbers are good though something around 30-40% PRs…i would look at Adoptive Cell Transfer and older versions of anti PD1/PDLs…if anti PD1 works, it will do so very fast…or not at all….

                                  boots

                                  • February 17, 2012 at 10:15 pm
                                  boot2aboot
                                  Participant

                                     

                                    You have to be HLA_A2 to be on moffitts anti-pd1tial…that leaves a lot of us out in the cold…anti PD-1, depending on the version, is about 35 % effective…that means PR and CRs…i think Yervoy is something like 15%…then there is IL2…5% and Adoptive  Cell Transfer which is rough and tough that includes IL2…numbers are good though something around 30-40% PRs…i would look at Adoptive Cell Transfer and older versions of anti PD1/PDLs…if anti PD1 works, it will do so very fast…or not at all….

                                    boots

                                    • February 17, 2012 at 10:15 pm
                                    boot2aboot
                                    Participant

                                       

                                      You have to be HLA_A2 to be on moffitts anti-pd1tial…that leaves a lot of us out in the cold…anti PD-1, depending on the version, is about 35 % effective…that means PR and CRs…i think Yervoy is something like 15%…then there is IL2…5% and Adoptive  Cell Transfer which is rough and tough that includes IL2…numbers are good though something around 30-40% PRs…i would look at Adoptive Cell Transfer and older versions of anti PD1/PDLs…if anti PD1 works, it will do so very fast…or not at all….

                                      boots

                                      • February 17, 2012 at 10:15 pm
                                      boot2aboot
                                      Participant

                                         

                                        You have to be HLA_A2 to be on moffitts anti-pd1tial…that leaves a lot of us out in the cold…anti PD-1, depending on the version, is about 35 % effective…that means PR and CRs…i think Yervoy is something like 15%…then there is IL2…5% and Adoptive  Cell Transfer which is rough and tough that includes IL2…numbers are good though something around 30-40% PRs…i would look at Adoptive Cell Transfer and older versions of anti PD1/PDLs…if anti PD1 works, it will do so very fast…or not at all….

                                        boots

                                        • February 17, 2012 at 1:57 am
                                        LynnLuc
                                        Participant

                                          I think originally they did not allow prior use of Yervoy, like in my trial ( mine was for surgically resected)…but the sister trial , which if those not NED has an arm with previous Yervoy use…now they are even combining the two ( or so I heard!)

                                        • February 16, 2012 at 11:12 pm
                                        MeNDave
                                        Participant

                                          Hi Deborah,

                                          I have heard that the anti-pd1 trials are showing better results than Yervoy (up to 33% response), but that is through the grapevine.  However, I do know that some of the anti-pd1 trials will not allow prior treatment with Yervoy, so you may want to keep that in mind. 

                                          Best wishes in whatever you decide,

                                          Maria

                                          • February 16, 2012 at 11:12 pm
                                          MeNDave
                                          Participant

                                            Hi Deborah,

                                            I have heard that the anti-pd1 trials are showing better results than Yervoy (up to 33% response), but that is through the grapevine.  However, I do know that some of the anti-pd1 trials will not allow prior treatment with Yervoy, so you may want to keep that in mind. 

                                            Best wishes in whatever you decide,

                                            Maria

                                            • February 18, 2012 at 12:00 am
                                            Rdev01
                                            Participant
                                              I am stage IV and just got out of Merck’s PD-1 MK 3475 trial Phase 1. It seemed to work well first month(some 15% reductions)but stopped for me based on 2nd month scans. I’m now on Zelboraf at 8th day and already am noticing significant reduction in palpable scalp/neck nodules.
                                              • February 18, 2012 at 12:00 am
                                              Rdev01
                                              Participant
                                                I am stage IV and just got out of Merck’s PD-1 MK 3475 trial Phase 1. It seemed to work well first month(some 15% reductions)but stopped for me based on 2nd month scans. I’m now on Zelboraf at 8th day and already am noticing significant reduction in palpable scalp/neck nodules.
                                                • February 18, 2012 at 12:00 am
                                                Rdev01
                                                Participant
                                                  I am stage IV and just got out of Merck’s PD-1 MK 3475 trial Phase 1. It seemed to work well first month(some 15% reductions)but stopped for me based on 2nd month scans. I’m now on Zelboraf at 8th day and already am noticing significant reduction in palpable scalp/neck nodules.
                                              Viewing 11 reply threads
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