Anti-PD1 Clinical Trial
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Anti-PD1 Clinical Trial

› Forums › General Melanoma Community › Anti-PD1 Clinical Trial

  • Post
    • February 4, 2015 at 11:57 pm
    newmanmark
    Participant

      Hello,

      I live in Toronto, Canada and I have stage 4 melanoma.  I have a single tumor on my pancreas that measures 8cm in length.  I have been dealing with it since 2012.  So far it has not spread beyond the pancreas but it continues to grow and will soon cause problems.  I did Interferon for 7 months in 2010 when I was first diagnosed.

      The options for me in Canada are;

      1.  BRAF – I am BRAF positive (Vemurafinib or Debrafinib)

      2.  Ipilimumab

      3.  Clinica Trial – includes a BRAF and a MEK Inhibitor

      If I fail on a BRAF and Ipilimumab then I qualify for Anti-PD1 under compassionate use.  It is not yet approved in Canada.

      The other option would be to look for a clinical trial with Anti-PD1 in the US.  I am looking for some informed opinions on how I should proceed.  Also, if anyone knows of recruiting clinical trials in the US I would be interested.

      Thank you

      Mark

    Viewing 5 reply threads
    • Replies
        • February 5, 2015 at 2:53 am
        arthurjedi007
        Participant

          You might want to consider a ipi nivo trial. I believe they have them running at mofffitt in Tampa. The data suggests good results but side affects can be serious. You need a really good team to monitor things. They also got an arm where they reversed where the pd1 is higher dose and ipi smaller so might be less side affects.

          Artie

          • February 5, 2015 at 2:53 am
          arthurjedi007
          Participant

            You might want to consider a ipi nivo trial. I believe they have them running at mofffitt in Tampa. The data suggests good results but side affects can be serious. You need a really good team to monitor things. They also got an arm where they reversed where the pd1 is higher dose and ipi smaller so might be less side affects.

            Artie

              • February 5, 2015 at 1:05 pm
              tschmith
              Participant

                I am Braf negative so I'm not in the same boat.  However I have tried surgery, radiation, Yervoy, a clinical trial at NIH in Bethesda, and now I'm getting Keytruda infusions.  I've had the best luck with Keytruda.  Since you live in Toronto, a trip for an opinion at Memorial Sloan Kettering in NYC might be an idea.  

                All my best to you!

                Terrie

                 

                • February 5, 2015 at 1:05 pm
                tschmith
                Participant

                  I am Braf negative so I'm not in the same boat.  However I have tried surgery, radiation, Yervoy, a clinical trial at NIH in Bethesda, and now I'm getting Keytruda infusions.  I've had the best luck with Keytruda.  Since you live in Toronto, a trip for an opinion at Memorial Sloan Kettering in NYC might be an idea.  

                  All my best to you!

                  Terrie

                   

                  • February 5, 2015 at 1:05 pm
                  tschmith
                  Participant

                    I am Braf negative so I'm not in the same boat.  However I have tried surgery, radiation, Yervoy, a clinical trial at NIH in Bethesda, and now I'm getting Keytruda infusions.  I've had the best luck with Keytruda.  Since you live in Toronto, a trip for an opinion at Memorial Sloan Kettering in NYC might be an idea.  

                    All my best to you!

                    Terrie

                     

                  • February 5, 2015 at 2:53 am
                  arthurjedi007
                  Participant

                    You might want to consider a ipi nivo trial. I believe they have them running at mofffitt in Tampa. The data suggests good results but side affects can be serious. You need a really good team to monitor things. They also got an arm where they reversed where the pd1 is higher dose and ipi smaller so might be less side affects.

                    Artie

                    • February 5, 2015 at 2:15 pm
                    ed williams
                    Participant

                      Hi Mark, there is one more thing that you can look into at the Princess Margaret in Toronto. They are now a location for TIL (Tumor-infiltrating lymphocytes) therapy. Dr.Pamela Ohashi is in charge of program. Two Oncologists involved are Dr. Anthony Joshua and Dr. Marcus Butler.You can look up information about TIL treatment, by looking for a video on youtube called "Adoptive Therapy for Melanoma " Melanoma Education Symposium by Patrick Hwu MD. from MD Anderson in Houston, Texas. Dr. Hwu is one of the leading figures in this type of treatment.  Wishing you the best. Ed

                      • February 5, 2015 at 2:15 pm
                      ed williams
                      Participant

                        Hi Mark, there is one more thing that you can look into at the Princess Margaret in Toronto. They are now a location for TIL (Tumor-infiltrating lymphocytes) therapy. Dr.Pamela Ohashi is in charge of program. Two Oncologists involved are Dr. Anthony Joshua and Dr. Marcus Butler.You can look up information about TIL treatment, by looking for a video on youtube called "Adoptive Therapy for Melanoma " Melanoma Education Symposium by Patrick Hwu MD. from MD Anderson in Houston, Texas. Dr. Hwu is one of the leading figures in this type of treatment.  Wishing you the best. Ed

                        • February 5, 2015 at 2:15 pm
                        ed williams
                        Participant

                          Hi Mark, there is one more thing that you can look into at the Princess Margaret in Toronto. They are now a location for TIL (Tumor-infiltrating lymphocytes) therapy. Dr.Pamela Ohashi is in charge of program. Two Oncologists involved are Dr. Anthony Joshua and Dr. Marcus Butler.You can look up information about TIL treatment, by looking for a video on youtube called "Adoptive Therapy for Melanoma " Melanoma Education Symposium by Patrick Hwu MD. from MD Anderson in Houston, Texas. Dr. Hwu is one of the leading figures in this type of treatment.  Wishing you the best. Ed

                            • February 5, 2015 at 9:01 pm
                            mbaelaporte
                            Participant

                              all great recommendations above and another doctor offering hope & treatments; Dr. Hamid Los Angeles Clinic 310-231-2135,  310-294-0438.

                              he made it all work for me – my physical ,  emotional & economical health

                              my insurance would not participate in clinical trials –  he retained Merck to cover all aspects of treatment- metrics, labs, clinics, antiPd1  etc….

                              I covered travel from Tacoma, Wa  /   there was even some reimbursement of lodging

                              Best to you

                              • February 5, 2015 at 9:01 pm
                              mbaelaporte
                              Participant

                                all great recommendations above and another doctor offering hope & treatments; Dr. Hamid Los Angeles Clinic 310-231-2135,  310-294-0438.

                                he made it all work for me – my physical ,  emotional & economical health

                                my insurance would not participate in clinical trials –  he retained Merck to cover all aspects of treatment- metrics, labs, clinics, antiPd1  etc….

                                I covered travel from Tacoma, Wa  /   there was even some reimbursement of lodging

                                Best to you

                                • February 5, 2015 at 9:01 pm
                                mbaelaporte
                                Participant

                                  all great recommendations above and another doctor offering hope & treatments; Dr. Hamid Los Angeles Clinic 310-231-2135,  310-294-0438.

                                  he made it all work for me – my physical ,  emotional & economical health

                                  my insurance would not participate in clinical trials –  he retained Merck to cover all aspects of treatment- metrics, labs, clinics, antiPd1  etc….

                                  I covered travel from Tacoma, Wa  /   there was even some reimbursement of lodging

                                  Best to you

                            Viewing 5 reply threads
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