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ASCO 2017: ipi 3mg/kg vs 10mg/kg
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ASCO 2017: ipi 3mg/kg vs 10mg/kg

› Forums › General Melanoma Community › ASCO 2017: ipi 3mg/kg vs 10mg/kg

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      • June 5, 2017 at 12:08 pm
      Jahendry12
      Participant

        Thank you For all you do for the folks on this board Celeste!

          • June 5, 2017 at 11:15 pm
          Bubbles
          Participant

            You are more than welcome…it takes a village. c

          • June 5, 2017 at 1:09 pm
          Hukill
          Participant

            I had 5 doese of ipi at the 3mg/kg dose. I had lots of side effects but none to the point of stopping treatment. I had a great response.

              • June 5, 2017 at 11:16 pm
              Bubbles
              Participant

                Congratulations!  That is wonderful.  c

                • June 5, 2017 at 11:22 pm
                Bubbles
                Participant

                  Hey H…

                  I see from your post above that you took the ipi/nivo combo…which is a little different from the folks treated in the abstracts I posted as they took only ipi or ipi with interferon…with ipi at either a dose of 3mg/kg or 10mg/kg.  None of these peeps got nivo.  Just didn't want to confuse anyone.  Nevertheless, so glad of your good results and hope that the kidney cyst is nothing more than that and your side effects are mangaged as best they can be.  I wish you well.  c

                • June 5, 2017 at 3:10 pm
                Jewel
                Participant
                  Like everybody else I just want to say thank you. The time you put into it must be exhausting not just mentally but physically. You make it so much easier for all of us. My question is in your research did you notice when they actually started your response time. My husband hado surgery late September 2014, and started IPI in Nov 2014 and finished 2015. We are truly bless3d to say he has been stable since. Scans due in Aug. Thanks for any and all replies.

                  Jewel

                    • June 5, 2017 at 11:14 pm
                    Bubbles
                    Participant

                      Hi Jewel, 

                      I am glad to hear of your husband's continued stability and send good wishes for his upcoming scans.  I am not entirely certain what you are asking.  The two abstracts in this post do not address time to response, they deal primarily with progression and relapse free survival.  For most folks in an adjuvant study, they are NED at the start…so knowing when a "response" kicks in is almost impossible to determine….and one can only measure how long they remain disease free.  For ipi historically, like anti-PD-1 (immunotherapy in general) time to response, for folks with measureable disease, is generally at about 12 weeks.  However, there are those who can gain a response much later.  Here is a graph that tells the tale:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/02/time-to-responseipi-vs-nivo-and-ipi.html  

                      As you can see…the ipi only folks are at the bottom.  Most of the response dots fall at about 12 weeks…but there is one person out at past 32 weeks.

                      Hope this helps.  C

                    • June 7, 2017 at 1:56 pm
                    laulamb
                    Participant

                      Hopefully I will be able to attest that 3mg of ipi works for Stage3!  When initially diagnosed with Stage 3a, I saw Dr. Kirkwood and his only recommendation was interferon.  My local oncologist recommeded a 2nd opinion, he knew interfon was an old drug and he said he never had anyone finish the interferon treatment that he gave it to.  I got a 2nd opinion from Dr. Schucter from Philadelphia and she recommeded no treatment but if I didn't want to go that route, we could see if my insurance would approve ipi at 3 mg and my insurance did.  I have tolerated it very well, just minior intestinal rummbling a few days after my treatment and that is it.  I am going to receive my 3rd maintenance dosage at the end of this month and then scans in August and last maintenace treatment in September / October.  I am currently 1 year NED.   

                        • June 7, 2017 at 2:54 pm
                        Bubbles
                        Participant

                          Geeze, Kirkwood is a trip!  I am ever so glad you got to take ipi at 3mg/kg.  Congrats on a year NED…..I hope it lasts forever!!!  c

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