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Bad news day what do we do now?
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Bad news day what do we do now?

› Forums › General Melanoma Community › Bad news day what do we do now?

  • Post
    • March 31, 2016 at 4:17 pm
    gcooperbl
    Participant

      So my dad got very bad news today….Pembro failed after three doses and it has spread to spine and gotten worse in brain. Doctor doesn't think Pembro will do anymore good, and it's having a bad effect on his body. He didn't even recommend chemo, we are devastated and we don't what to do. Palliative care I guess and make his last few months a joyful one. 

      i hate this disease I hate it so much but we must continue to fight it and keep up the research

       

       

       

    Viewing 11 reply threads
    • Replies
        • March 31, 2016 at 5:26 pm
        Scooby123
        Participant

          Hi , 

          sorry you are dealing with this it's horrible disease. I looked at your profile you live in uk. 

          Has your dad not been offered ippi or nivola or combo both together. May I ask how old your dad is . His your dad having bad side effects to drug or just not well in himself 

          i do recall everyone response to keydruda has been different in how many doses they have before takes effect. I am sure others on it will give you more feedback on that.

          what has your consultant said regarding treatment offers.

          scooby123❤️

          • March 31, 2016 at 5:26 pm
          Scooby123
          Participant

            Hi , 

            sorry you are dealing with this it's horrible disease. I looked at your profile you live in uk. 

            Has your dad not been offered ippi or nivola or combo both together. May I ask how old your dad is . His your dad having bad side effects to drug or just not well in himself 

            i do recall everyone response to keydruda has been different in how many doses they have before takes effect. I am sure others on it will give you more feedback on that.

            what has your consultant said regarding treatment offers.

            scooby123❤️

              • March 31, 2016 at 5:43 pm
              Scooby123
              Participant

                sorry did see your dads age, is none of his tumours in liver , lungs stable , or has everything started getting worse since keydruda. 

                • March 31, 2016 at 5:43 pm
                Scooby123
                Participant

                  sorry did see your dads age, is none of his tumours in liver , lungs stable , or has everything started getting worse since keydruda. 

                  • March 31, 2016 at 5:43 pm
                  Scooby123
                  Participant

                    sorry did see your dads age, is none of his tumours in liver , lungs stable , or has everything started getting worse since keydruda. 

                  • March 31, 2016 at 5:26 pm
                  Scooby123
                  Participant

                    Hi , 

                    sorry you are dealing with this it's horrible disease. I looked at your profile you live in uk. 

                    Has your dad not been offered ippi or nivola or combo both together. May I ask how old your dad is . His your dad having bad side effects to drug or just not well in himself 

                    i do recall everyone response to keydruda has been different in how many doses they have before takes effect. I am sure others on it will give you more feedback on that.

                    what has your consultant said regarding treatment offers.

                    scooby123❤️

                    • March 31, 2016 at 7:12 pm
                    Polymath
                    Participant

                      Consider continuing on Pembro despite the early failure.  Or switch to the sister drug, Nivolumab and/or in combo with iplumumab.  There are many cases of initial increased tumor activity or inflammation followed by regression.  Radiation treatment added to the immunotherapy may also give an added boost due to the now proven "abscopal effect".  I am a "late bloomer" who resisted all the immunotherapy treatments until being on the ipi/nivo combo and adding radiation.  I have finally gotten at least a partial response.  Since you are only considering palliative care at this point, one more aggressive round of treatment seems like worth trying unless side-effects diminish quality of life considerably.  Best to your and your family at a difficult time.

                      Gary

                      • March 31, 2016 at 7:12 pm
                      Polymath
                      Participant

                        Consider continuing on Pembro despite the early failure.  Or switch to the sister drug, Nivolumab and/or in combo with iplumumab.  There are many cases of initial increased tumor activity or inflammation followed by regression.  Radiation treatment added to the immunotherapy may also give an added boost due to the now proven "abscopal effect".  I am a "late bloomer" who resisted all the immunotherapy treatments until being on the ipi/nivo combo and adding radiation.  I have finally gotten at least a partial response.  Since you are only considering palliative care at this point, one more aggressive round of treatment seems like worth trying unless side-effects diminish quality of life considerably.  Best to your and your family at a difficult time.

                        Gary

                        • March 31, 2016 at 7:12 pm
                        Polymath
                        Participant

                          Consider continuing on Pembro despite the early failure.  Or switch to the sister drug, Nivolumab and/or in combo with iplumumab.  There are many cases of initial increased tumor activity or inflammation followed by regression.  Radiation treatment added to the immunotherapy may also give an added boost due to the now proven "abscopal effect".  I am a "late bloomer" who resisted all the immunotherapy treatments until being on the ipi/nivo combo and adding radiation.  I have finally gotten at least a partial response.  Since you are only considering palliative care at this point, one more aggressive round of treatment seems like worth trying unless side-effects diminish quality of life considerably.  Best to your and your family at a difficult time.

                          Gary

                          • March 31, 2016 at 7:13 pm
                          Laurie flora
                          Participant

                            My name is Laurie my fiancée was diagnosed with malignant melanoma 2 weeks ago he has been coughing up blood for 2 months now finally was sent to a cardio thoracic surgery center a week ago. Now this specialist is putting Keith through everything his regular Dr. Did because he wasn't satisfied with the other Dr. Results he goes for a pet scan on March4 and another biopsy on March 7 and we realize time is of the essence. It saddens me very much to think of life without him and I'm always researching things about malignant melanoma metastasis. I feel they should have already done something for him. Can anyone please tell me what to do he has a malignant tumor composed of nested proliferation of atypical cells with epitheloid appearance and nests present in the overlying epithelium with mitotic activity. And they said it was either metastatic or arising at this site. Can someone please tell me were else we could go and who the best surgeons are for this and what to expect because I see a difference in him every day and I feel the dr. Should be ding more. Thanks to everyone and prayers for all Laurie 

                            • March 31, 2016 at 7:13 pm
                            Laurie flora
                            Participant

                              My name is Laurie my fiancée was diagnosed with malignant melanoma 2 weeks ago he has been coughing up blood for 2 months now finally was sent to a cardio thoracic surgery center a week ago. Now this specialist is putting Keith through everything his regular Dr. Did because he wasn't satisfied with the other Dr. Results he goes for a pet scan on March4 and another biopsy on March 7 and we realize time is of the essence. It saddens me very much to think of life without him and I'm always researching things about malignant melanoma metastasis. I feel they should have already done something for him. Can anyone please tell me what to do he has a malignant tumor composed of nested proliferation of atypical cells with epitheloid appearance and nests present in the overlying epithelium with mitotic activity. And they said it was either metastatic or arising at this site. Can someone please tell me were else we could go and who the best surgeons are for this and what to expect because I see a difference in him every day and I feel the dr. Should be ding more. Thanks to everyone and prayers for all Laurie 

                                • March 31, 2016 at 9:15 pm
                                ed williams
                                Participant

                                  Hi Laurie, some more details would be helpfull like where you are located and what kind of Dr. is treating him now. Ed

                                  • March 31, 2016 at 9:15 pm
                                  ed williams
                                  Participant

                                    Hi Laurie, some more details would be helpfull like where you are located and what kind of Dr. is treating him now. Ed

                                    • April 1, 2016 at 12:19 pm
                                    Laurie flora
                                    Participant

                                      We are located in Martin to 3 hours from Nashville to his dr sent him to a cardio thoracic surgery center in Jackson tn. Thank you for responding!

                                      • April 1, 2016 at 12:19 pm
                                      Laurie flora
                                      Participant

                                        We are located in Martin to 3 hours from Nashville to his dr sent him to a cardio thoracic surgery center in Jackson tn. Thank you for responding!

                                        • April 1, 2016 at 12:19 pm
                                        Laurie flora
                                        Participant

                                          We are located in Martin to 3 hours from Nashville to his dr sent him to a cardio thoracic surgery center in Jackson tn. Thank you for responding!

                                          • March 31, 2016 at 9:15 pm
                                          ed williams
                                          Participant

                                            Hi Laurie, some more details would be helpfull like where you are located and what kind of Dr. is treating him now. Ed

                                          • March 31, 2016 at 7:13 pm
                                          Laurie flora
                                          Participant

                                            My name is Laurie my fiancée was diagnosed with malignant melanoma 2 weeks ago he has been coughing up blood for 2 months now finally was sent to a cardio thoracic surgery center a week ago. Now this specialist is putting Keith through everything his regular Dr. Did because he wasn't satisfied with the other Dr. Results he goes for a pet scan on March4 and another biopsy on March 7 and we realize time is of the essence. It saddens me very much to think of life without him and I'm always researching things about malignant melanoma metastasis. I feel they should have already done something for him. Can anyone please tell me what to do he has a malignant tumor composed of nested proliferation of atypical cells with epitheloid appearance and nests present in the overlying epithelium with mitotic activity. And they said it was either metastatic or arising at this site. Can someone please tell me were else we could go and who the best surgeons are for this and what to expect because I see a difference in him every day and I feel the dr. Should be ding more. Thanks to everyone and prayers for all Laurie 

                                            • March 31, 2016 at 9:33 pm
                                            MoiraM
                                            Participant

                                              What does your dad want to do? Is it a matter of the quality of the days rather than the number of them?

                                              Thinking of you and your family.

                                              • March 31, 2016 at 9:33 pm
                                              MoiraM
                                              Participant

                                                What does your dad want to do? Is it a matter of the quality of the days rather than the number of them?

                                                Thinking of you and your family.

                                                • March 31, 2016 at 9:33 pm
                                                MoiraM
                                                Participant

                                                  What does your dad want to do? Is it a matter of the quality of the days rather than the number of them?

                                                  Thinking of you and your family.

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