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BRAF positive and negative?
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BRAF positive and negative?

› Forums › General Melanoma Community › BRAF positive and negative?

  • Post
    • January 20, 2014 at 4:09 pm
    bodrum
    Participant

      Is this possible?  my birthmark turned out to be BRAF positive but the result of the SLND turned out to be BRAF negative.  The pathalogist found 6 cells in one of my lymph nodes.   Now, one of the doctors is saying that maybe those 6 cells are not melanoma… 

      I'm about to get the CLND. So confused…. 

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    • Replies
        • January 20, 2014 at 4:24 pm
        kpcollins31
        Participant

          If it were me, I would be really hesitant to undergo a CLND. From your profile and what you state above, they found 6 cells in a single lymph node… and now they are not sure if they are melanoma or not. Make sure you are seeing a melanoma specialist on this before the CLND. There is currently a trial out there exploring the effectiveness of a CLND so I would say the jury is out. I would urge you to get a second opinion.

          Kevin

          • January 20, 2014 at 4:24 pm
          kpcollins31
          Participant

            If it were me, I would be really hesitant to undergo a CLND. From your profile and what you state above, they found 6 cells in a single lymph node… and now they are not sure if they are melanoma or not. Make sure you are seeing a melanoma specialist on this before the CLND. There is currently a trial out there exploring the effectiveness of a CLND so I would say the jury is out. I would urge you to get a second opinion.

            Kevin

            • January 20, 2014 at 4:24 pm
            kpcollins31
            Participant

              If it were me, I would be really hesitant to undergo a CLND. From your profile and what you state above, they found 6 cells in a single lymph node… and now they are not sure if they are melanoma or not. Make sure you are seeing a melanoma specialist on this before the CLND. There is currently a trial out there exploring the effectiveness of a CLND so I would say the jury is out. I would urge you to get a second opinion.

              Kevin

                • January 20, 2014 at 6:09 pm
                momof4boys
                Participant

                  I also would be hesitant on that clnd unless they are certain. I had it done over the summer and it was pretty rough and have now been left with lymphadema in my leg. That in itself is like fighting a whole new battle which will change your life from here on out. While I know I had to do it I sometimes wish I hadn't because of the lymphadema.

                  • January 20, 2014 at 6:09 pm
                  momof4boys
                  Participant

                    I also would be hesitant on that clnd unless they are certain. I had it done over the summer and it was pretty rough and have now been left with lymphadema in my leg. That in itself is like fighting a whole new battle which will change your life from here on out. While I know I had to do it I sometimes wish I hadn't because of the lymphadema.

                    • January 20, 2014 at 6:09 pm
                    momof4boys
                    Participant

                      I also would be hesitant on that clnd unless they are certain. I had it done over the summer and it was pretty rough and have now been left with lymphadema in my leg. That in itself is like fighting a whole new battle which will change your life from here on out. While I know I had to do it I sometimes wish I hadn't because of the lymphadema.

                    • January 21, 2014 at 3:57 am
                    JerryfromFauq
                    Participant

                      Interesting case.  Did they both conduct the same BRAF test?  The term BRAF + means that the particular BRAF DNA mutation tested for was found.  The term BRAF- means that the particular BRAF DNA mutation tested for was not found.  Both terms imply that the tumor cells were not sequenced to see all mutations they contained, but that only certain mutations were looked for.   Have you actually seen the Patholgist Report?  If not, get it.  I would definitely want a more definite resolution before I would allow a CLND.  Are you at a NCI-designated cancer cente.   NCI-designated cancer centers are at the forefront of NCI-supported efforts at universities and cancer research centers across the United States that are developing and translating scientific knowledge from promising laboratory discoveries into new treatments for cancer patients.    Are you seeing a Melanoma Specialist Oncologist?  Do they consideer what they found tobe micro mets.  Don't hesitate to get a seond opinion from another Cancer Center.

                       

                      • January 21, 2014 at 3:57 am
                      JerryfromFauq
                      Participant

                        Interesting case.  Did they both conduct the same BRAF test?  The term BRAF + means that the particular BRAF DNA mutation tested for was found.  The term BRAF- means that the particular BRAF DNA mutation tested for was not found.  Both terms imply that the tumor cells were not sequenced to see all mutations they contained, but that only certain mutations were looked for.   Have you actually seen the Patholgist Report?  If not, get it.  I would definitely want a more definite resolution before I would allow a CLND.  Are you at a NCI-designated cancer cente.   NCI-designated cancer centers are at the forefront of NCI-supported efforts at universities and cancer research centers across the United States that are developing and translating scientific knowledge from promising laboratory discoveries into new treatments for cancer patients.    Are you seeing a Melanoma Specialist Oncologist?  Do they consideer what they found tobe micro mets.  Don't hesitate to get a seond opinion from another Cancer Center.

                         

                        • January 21, 2014 at 3:57 am
                        JerryfromFauq
                        Participant

                          Interesting case.  Did they both conduct the same BRAF test?  The term BRAF + means that the particular BRAF DNA mutation tested for was found.  The term BRAF- means that the particular BRAF DNA mutation tested for was not found.  Both terms imply that the tumor cells were not sequenced to see all mutations they contained, but that only certain mutations were looked for.   Have you actually seen the Patholgist Report?  If not, get it.  I would definitely want a more definite resolution before I would allow a CLND.  Are you at a NCI-designated cancer cente.   NCI-designated cancer centers are at the forefront of NCI-supported efforts at universities and cancer research centers across the United States that are developing and translating scientific knowledge from promising laboratory discoveries into new treatments for cancer patients.    Are you seeing a Melanoma Specialist Oncologist?  Do they consideer what they found tobe micro mets.  Don't hesitate to get a seond opinion from another Cancer Center.

                           

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