› Forums › Cutaneous Melanoma Community › Can the Body’s Immune Response Help Treat Cancer?
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green8300.
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- April 22, 2012 at 5:46 am
http://www.newyorker.com/services/presscenter/2012/04/23/120423pr_press_releases
Can the Body’s Immune Response Help Treat Cancer?http://www.newyorker.com/services/presscenter/2012/04/23/120423pr_press_releases
Can the Body’s Immune Response Help Treat Cancer?In “The T-Cell Army” (p. 24), Jerome Groopman looks at new cancer treatments that use the body’s own immune system to fight the disease. The idea that the body’s immune system could play a crucial role in eradicating cancer originated in the late nineteenth century, but was not embraced by the scientific community. More recently, the “war on cancer” promised that the disease would be beaten within ten years; in 1980, a possible cure for cancer, derived from the immune system, appeared on the cover of Time. But it, too, failed. Jim Allison, the director of the tumor-immunology program at Memorial Sloan-Kettering, began his career by focussing on why the body’s T-cells (the potent type of white blood cell that destroys cells infected with microbes it recognizes as foreign) failed to recognize cancer as being aberrant. In the beginning, “many people thought that the immune system didn’t play any role in cancer,” Allison tells Groopman, but, in 1987, researchers in France discovered a protein called cytotoxic T-lymphocyte antigen-4, or CTLA-4, which protruded from the T-cell’s surface. Contrary to other reseachers at the time, who thought that CTLA-4 increased the activity of the immune system, Allison and his team believed that CTLA-4 actually acted as a brake on the T-cells. “We ought to free the immune system, so it can attack tumor cells,” Allison explains to Groopman. The resultant CTLA-4 antibody is “unlike any other drug you know,” Allison tells Groopman. “You are not treating the cancer—you are treating the immune system. And it was the first drug of any type to show a survival benefit in advanced melanoma patients in a randomized trial.” In March, 2011, the National Cancer Institute announced that it would fund a network of twenty-seven universities and cancer centers across North America to conduct trials of immune therapies, and, recently, patients who had not responded to available cancer therapies have “shown dramatic and unexpected responses to a new series of treatments that unleash the immune system,” Groopman writes. Groopman speaks to two patients diagnosed with metastatic melanoma who are now in remission after receiving experimental immunotherapy treatments—though not without severe side effects. Attacks on the skin, intestines, lungs, liver, thyroid, pituitary gland, kidneys, or pancreas are all possibilities . Still, in trials of the drug, nearly a quarter of patients who had been given a seven-month life expectancy were still alive at three to five years. However, Allison warns, “you’ve got to be careful about using the word ‘cured,’ because some patients have residual tumors. But it doesn’t matter, because their cancers are not growing. And in others tumors just pop up and then go away. So it’s become something of a chronic condition,” rather than a death sentence. “The future is about thoughtful combinations, different antibodies, perhaps with targeted therapies,” Jedd Wolchok, a clinician at Memorial Sloan-Kettering who worked on the early trials, tells Groopman. “There won’t be a single silver bullet for everyone.”
Read more http://www.newyorker.com/services/presscenter/2012/04/23/120423pr_press_releases#ixzz1skFhoSmd
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- April 22, 2012 at 9:59 pm
. I am betting my life on the immune system destroying the melanoma cancer. The stratergy is that the immune system has to attack every cancer cell. To do that you need a plan. One therapy will just won't do it. Dr.Allison warns, “you’ve got to be careful about using the word ‘cured,’ because some patients have residual tumors. You must kill all the cancer cells to be CURED.
Based on my own experience and over 6 years of research you will need combinatorial therapy. This therapy will have to be given systematically to train the T-cells to become the Army needed to eradicate the melanoma cancer.
You will need some things to take into battle.
1) Tumor-specific antigens… needed to activate the T-cells and guide them to the tumor site.
2) The "Danger Signal".. Pathogen-Associated Molecular Patterns (PAMPs) and Damage-Associated Molecular Patterns (DAMPs) using Toll Like recpetors (TLRs) to initiate innate immune system.. the first-line of defence
3) Checkpoint blockade of the two most potent immune inhibitors of T-cell activation, CTLA-4 and PD1 receptors
4) Actiavtion of the (M1) macrophages and DCs to produce IL-12 and IFN-gamma
5) The progapgation and differentation of the T-cells into the TH1 phenotype
6) Growth Factor that will help the T-cell (CD-8+) activate, mature into a (CTL) Cytotoxic T Lymphocyte, maintain fuctionality and survival….IL-2.
When you couple the innate immune system with Danger Signals, (TLR), Yervoy and or Anti-PD1 and IL-2, you just might erdaicate all the Melanoma. And for Older Patients, you might want to add 5–fluorouracil (5Fu) to deplete the Myeloid-derived suppressor cell (MDSC) also Known as al oo also known as Myeloid suppressive cells (MSC)
No one therapy can make this happen. You need Combinatorial Therapy. That will CURE melanoma (my opinion).
I am betting my life on it. Stage IV survivor diagnosed 2005, progressed with lung matastases .. combinatorial therapy, no surgery 2006 with no additional therapy since 2007.
Best Regards
Jimmy B
(PAMPs) ))
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- April 24, 2012 at 11:46 am
Jimmy, thanks for posting this important info. I think that an appropriate immune response is needed in order to control and/or eradicate all melanoma cells. It certainly looks like sophisticated combinatorial therapy is probably essential to enable one to achieve a durable remission or possible cure.
Best wishes
Frank from Australia
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- April 24, 2012 at 11:46 am
Jimmy, thanks for posting this important info. I think that an appropriate immune response is needed in order to control and/or eradicate all melanoma cells. It certainly looks like sophisticated combinatorial therapy is probably essential to enable one to achieve a durable remission or possible cure.
Best wishes
Frank from Australia
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- May 9, 2012 at 10:15 pm
yh ive been to raw food seminars and that got lots of people in there cured of it,,,,,,,i shouldnt say raw i should say living foods,,,,,,,,,,research it,,,,,,,,,,,i changed my diet completely lots of greens no meat, sugar even natural sugar, bread, ,,,,,i was in the car last night driving with these people to the seminar and a lady had a alkaline tester in her purse i out a strip under my tongue,,,,,,,,,,,,and it was between 7 and 7.5 thats where things need to be for ur body to fight off things in a big way,,,,,lookinto it people its very powerful western medicine aint gonna tell u about it,,,,its all about strenthening ur immune system,,,,,,,,,,,,,,,,,,,,i had my lymphs taken out other day,,,,,,,by the way,,,,,,,,,,,still waiting for results,,,,,,,,,,,,,,,,but get on the healthy eating it could save ur life,,,,,i guess the free radicals,,,,,,cant survive in that environment so it kills them and cancer cells,,,,,also get kagen alkaline water buck a gallon,,,,alkaline level 9.5 i think educate urself,,,,,,this can change everything,,,,,,,it was held at a raw food restaurant,,,,i told the women at 12pm on the way out what i was going thru she pulled me off to the side and said she had a brain tumor,,,and got thru it,,,thats why she started this restaurant 15 years ago,,,,,,,,,,,,,,cheers
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- May 9, 2012 at 10:15 pm
yh ive been to raw food seminars and that got lots of people in there cured of it,,,,,,,i shouldnt say raw i should say living foods,,,,,,,,,,research it,,,,,,,,,,,i changed my diet completely lots of greens no meat, sugar even natural sugar, bread, ,,,,,i was in the car last night driving with these people to the seminar and a lady had a alkaline tester in her purse i out a strip under my tongue,,,,,,,,,,,,and it was between 7 and 7.5 thats where things need to be for ur body to fight off things in a big way,,,,,lookinto it people its very powerful western medicine aint gonna tell u about it,,,,its all about strenthening ur immune system,,,,,,,,,,,,,,,,,,,,i had my lymphs taken out other day,,,,,,,by the way,,,,,,,,,,,still waiting for results,,,,,,,,,,,,,,,,but get on the healthy eating it could save ur life,,,,,i guess the free radicals,,,,,,cant survive in that environment so it kills them and cancer cells,,,,,also get kagen alkaline water buck a gallon,,,,alkaline level 9.5 i think educate urself,,,,,,this can change everything,,,,,,,it was held at a raw food restaurant,,,,i told the women at 12pm on the way out what i was going thru she pulled me off to the side and said she had a brain tumor,,,and got thru it,,,thats why she started this restaurant 15 years ago,,,,,,,,,,,,,,cheers
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- May 9, 2012 at 10:15 pm
yh ive been to raw food seminars and that got lots of people in there cured of it,,,,,,,i shouldnt say raw i should say living foods,,,,,,,,,,research it,,,,,,,,,,,i changed my diet completely lots of greens no meat, sugar even natural sugar, bread, ,,,,,i was in the car last night driving with these people to the seminar and a lady had a alkaline tester in her purse i out a strip under my tongue,,,,,,,,,,,,and it was between 7 and 7.5 thats where things need to be for ur body to fight off things in a big way,,,,,lookinto it people its very powerful western medicine aint gonna tell u about it,,,,its all about strenthening ur immune system,,,,,,,,,,,,,,,,,,,,i had my lymphs taken out other day,,,,,,,by the way,,,,,,,,,,,still waiting for results,,,,,,,,,,,,,,,,but get on the healthy eating it could save ur life,,,,,i guess the free radicals,,,,,,cant survive in that environment so it kills them and cancer cells,,,,,also get kagen alkaline water buck a gallon,,,,alkaline level 9.5 i think educate urself,,,,,,this can change everything,,,,,,,it was held at a raw food restaurant,,,,i told the women at 12pm on the way out what i was going thru she pulled me off to the side and said she had a brain tumor,,,and got thru it,,,thats why she started this restaurant 15 years ago,,,,,,,,,,,,,,cheers
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- April 24, 2012 at 11:46 am
Jimmy, thanks for posting this important info. I think that an appropriate immune response is needed in order to control and/or eradicate all melanoma cells. It certainly looks like sophisticated combinatorial therapy is probably essential to enable one to achieve a durable remission or possible cure.
Best wishes
Frank from Australia
-
- April 22, 2012 at 9:59 pm
. I am betting my life on the immune system destroying the melanoma cancer. The stratergy is that the immune system has to attack every cancer cell. To do that you need a plan. One therapy will just won't do it. Dr.Allison warns, “you’ve got to be careful about using the word ‘cured,’ because some patients have residual tumors. You must kill all the cancer cells to be CURED.
Based on my own experience and over 6 years of research you will need combinatorial therapy. This therapy will have to be given systematically to train the T-cells to become the Army needed to eradicate the melanoma cancer.
You will need some things to take into battle.
1) Tumor-specific antigens… needed to activate the T-cells and guide them to the tumor site.
2) The "Danger Signal".. Pathogen-Associated Molecular Patterns (PAMPs) and Damage-Associated Molecular Patterns (DAMPs) using Toll Like recpetors (TLRs) to initiate innate immune system.. the first-line of defence
3) Checkpoint blockade of the two most potent immune inhibitors of T-cell activation, CTLA-4 and PD1 receptors
4) Actiavtion of the (M1) macrophages and DCs to produce IL-12 and IFN-gamma
5) The progapgation and differentation of the T-cells into the TH1 phenotype
6) Growth Factor that will help the T-cell (CD-8+) activate, mature into a (CTL) Cytotoxic T Lymphocyte, maintain fuctionality and survival….IL-2.
When you couple the innate immune system with Danger Signals, (TLR), Yervoy and or Anti-PD1 and IL-2, you just might erdaicate all the Melanoma. And for Older Patients, you might want to add 5–fluorouracil (5Fu) to deplete the Myeloid-derived suppressor cell (MDSC) also Known as al oo also known as Myeloid suppressive cells (MSC)
No one therapy can make this happen. You need Combinatorial Therapy. That will CURE melanoma (my opinion).
I am betting my life on it. Stage IV survivor diagnosed 2005, progressed with lung matastases .. combinatorial therapy, no surgery 2006 with no additional therapy since 2007.
Best Regards
Jimmy B
(PAMPs) ))
-
- April 22, 2012 at 9:59 pm
. I am betting my life on the immune system destroying the melanoma cancer. The stratergy is that the immune system has to attack every cancer cell. To do that you need a plan. One therapy will just won't do it. Dr.Allison warns, “you’ve got to be careful about using the word ‘cured,’ because some patients have residual tumors. You must kill all the cancer cells to be CURED.
Based on my own experience and over 6 years of research you will need combinatorial therapy. This therapy will have to be given systematically to train the T-cells to become the Army needed to eradicate the melanoma cancer.
You will need some things to take into battle.
1) Tumor-specific antigens… needed to activate the T-cells and guide them to the tumor site.
2) The "Danger Signal".. Pathogen-Associated Molecular Patterns (PAMPs) and Damage-Associated Molecular Patterns (DAMPs) using Toll Like recpetors (TLRs) to initiate innate immune system.. the first-line of defence
3) Checkpoint blockade of the two most potent immune inhibitors of T-cell activation, CTLA-4 and PD1 receptors
4) Actiavtion of the (M1) macrophages and DCs to produce IL-12 and IFN-gamma
5) The progapgation and differentation of the T-cells into the TH1 phenotype
6) Growth Factor that will help the T-cell (CD-8+) activate, mature into a (CTL) Cytotoxic T Lymphocyte, maintain fuctionality and survival….IL-2.
When you couple the innate immune system with Danger Signals, (TLR), Yervoy and or Anti-PD1 and IL-2, you just might erdaicate all the Melanoma. And for Older Patients, you might want to add 5–fluorouracil (5Fu) to deplete the Myeloid-derived suppressor cell (MDSC) also Known as al oo also known as Myeloid suppressive cells (MSC)
No one therapy can make this happen. You need Combinatorial Therapy. That will CURE melanoma (my opinion).
I am betting my life on it. Stage IV survivor diagnosed 2005, progressed with lung matastases .. combinatorial therapy, no surgery 2006 with no additional therapy since 2007.
Best Regards
Jimmy B
(PAMPs) ))
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