Chloroquine’s Antimelanoma Activity
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Chloroquine’s Antimelanoma Activity

› Forums › General Melanoma Community › Chloroquine’s Antimelanoma Activity

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    • August 15, 2013 at 8:22 pm
    lou2
    Participant

      Commentary

      Journal of Investigative Dermatology (2013) 133, 2133–2135; doi:10.1038/jid.2013.135

      PUMA: A Puzzle Piece in Chloroquine’s Antimelanoma Activity

      Ravi K Amaravadi1

      Commentary

      Journal of Investigative Dermatology (2013) 133, 2133–2135; doi:10.1038/jid.2013.135

      PUMA: A Puzzle Piece in Chloroquine’s Antimelanoma Activity

      Ravi K Amaravadi1

      1Abramson Cancer Center and Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

      Correspondence: Ravi K. Amaravadi, Abramson Cancer Center, Department of Medicine, Perelman School of Medicine, 16 Penn Tower, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USA. E-mail: [email protected]

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      Abstract

      Chloroquine (CQ) can induce cell death in a subset of cancer cell lines, and some melanoma cell lines are quite susceptible. Although it is well known that CQ impairs lysosomal function and can serve as an autophagy inhibitor, the molecular target of CQ and the subsequent cascade of events that lead to cell death are not fully understood. Recent evidence indicates that in melanoma cell lines, CQ induces apoptosis by preventing degradation of the pro-apoptotic BH3-only protein p53-upregulated modulator of apoptosis. This finding adds to the unfolding story of CQ’s mechanism of action as a cancer therapeutic agent.

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