Combo therapy and side effect profiles including anti-PD1
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Combo therapy and side effect profiles including anti-PD1

› Forums › General Melanoma Community › Combo therapy and side effect profiles including anti-PD1

  • Post
    • August 30, 2014 at 1:30 am
    Bubbles
    Participant

      Mostly for Gsamsa and Brian P, as well as any of you who are interested: After we had talked about pneumonitis…. I was reading, then posting, an article that actually included some data about its occurrence with anti-PD1 therapy!  The article is a little older but does address some of the latest combo therapy.  And…because it is a compilation of data from a year ago….it breaks down the beginning results, with commentary re side effects, and some pretty cool, straight forward explanations of how it all works.

      For what it's worth:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/08/combination-therapies-for-melanoma.html

      Wishing you all my best!  Celeste

    Viewing 2 reply threads
    • Replies
        • August 31, 2014 at 4:30 am
        BrianP
        Participant

          Thanks Celeste.

          • August 31, 2014 at 4:30 am
          BrianP
          Participant

            Thanks Celeste.

              • August 31, 2014 at 5:48 pm
              ConstructionCM
              Participant

                Celeste and anyone else,

                 

                Thank you for the update.  The advances in treatment within the past couple of years have been incredible.  I have Stage 4 melanoma and have just went through 4 infusions of Yervoy and just did my second of PD1.  Other than a rash,  I have not had that bad of side effects.  I have to say though that I occassionally get moody and have been more apt to lose my temper which is not my normal demeanor.  Have other people encountered that and does the meds impact your hormones?  Could this be part of what I am experiencing?  Thank you for your help!

                Chris  

                • August 31, 2014 at 5:48 pm
                ConstructionCM
                Participant

                  Celeste and anyone else,

                   

                  Thank you for the update.  The advances in treatment within the past couple of years have been incredible.  I have Stage 4 melanoma and have just went through 4 infusions of Yervoy and just did my second of PD1.  Other than a rash,  I have not had that bad of side effects.  I have to say though that I occassionally get moody and have been more apt to lose my temper which is not my normal demeanor.  Have other people encountered that and does the meds impact your hormones?  Could this be part of what I am experiencing?  Thank you for your help!

                  Chris  

                  • August 31, 2014 at 6:46 pm
                  Bubbles
                  Participant

                    Hey Chris,

                    That is pretty tricky to answer.  Being stage IV, dealing with ipi…and presumably not having it do its job as well as was hoped, since you are now on anti-PD1, is certainly enough to put a person in a bad mood!!!  Not to mention the fatigue caused by both ipi and anti-PD1 could certainly be wearing.  We know that both of those drugs affect the endocrine system…..which can then impact all sorts of things including various hormones, etc.  Unfortunately, docs tend to look at our side effects/desired effects in the light of:  Is she croaking?  Have her labs gone nuts?  How are the vital signs and scan results?  Which is understandable….but….it can leave out some important factors.  However, as more folks have taken both of these drugs, more information is coming to light, in relation to both the side effects themselves and how docs need to treat them.  This is a post I made about lesser known side effects to ipi that are being recognized more recently:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/03/melanoma-patients-teach-us-more-about.html

                    Here is a post I put together about known side effects to anti-PD1:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2013/10/side-effects-of-nivolumab.html

                    I'm not sure how much these will help you…  I would certainly talk to my doc about how you are feeling, how often these mood swings happen and when.  Keeping a diary of events might help you and the doc figure things out.  Also, if brain mets have ever been an issue for you, and sadly I guess…even if they haven't, you do have to consider if any brain issue may be in play…though, hopefully, that is unlikely.

                    Hang in there.  Celeste

                     

                    • August 31, 2014 at 6:46 pm
                    Bubbles
                    Participant

                      Hey Chris,

                      That is pretty tricky to answer.  Being stage IV, dealing with ipi…and presumably not having it do its job as well as was hoped, since you are now on anti-PD1, is certainly enough to put a person in a bad mood!!!  Not to mention the fatigue caused by both ipi and anti-PD1 could certainly be wearing.  We know that both of those drugs affect the endocrine system…..which can then impact all sorts of things including various hormones, etc.  Unfortunately, docs tend to look at our side effects/desired effects in the light of:  Is she croaking?  Have her labs gone nuts?  How are the vital signs and scan results?  Which is understandable….but….it can leave out some important factors.  However, as more folks have taken both of these drugs, more information is coming to light, in relation to both the side effects themselves and how docs need to treat them.  This is a post I made about lesser known side effects to ipi that are being recognized more recently:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/03/melanoma-patients-teach-us-more-about.html

                      Here is a post I put together about known side effects to anti-PD1:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2013/10/side-effects-of-nivolumab.html

                      I'm not sure how much these will help you…  I would certainly talk to my doc about how you are feeling, how often these mood swings happen and when.  Keeping a diary of events might help you and the doc figure things out.  Also, if brain mets have ever been an issue for you, and sadly I guess…even if they haven't, you do have to consider if any brain issue may be in play…though, hopefully, that is unlikely.

                      Hang in there.  Celeste

                       

                      • August 31, 2014 at 6:46 pm
                      Bubbles
                      Participant

                        Hey Chris,

                        That is pretty tricky to answer.  Being stage IV, dealing with ipi…and presumably not having it do its job as well as was hoped, since you are now on anti-PD1, is certainly enough to put a person in a bad mood!!!  Not to mention the fatigue caused by both ipi and anti-PD1 could certainly be wearing.  We know that both of those drugs affect the endocrine system…..which can then impact all sorts of things including various hormones, etc.  Unfortunately, docs tend to look at our side effects/desired effects in the light of:  Is she croaking?  Have her labs gone nuts?  How are the vital signs and scan results?  Which is understandable….but….it can leave out some important factors.  However, as more folks have taken both of these drugs, more information is coming to light, in relation to both the side effects themselves and how docs need to treat them.  This is a post I made about lesser known side effects to ipi that are being recognized more recently:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/03/melanoma-patients-teach-us-more-about.html

                        Here is a post I put together about known side effects to anti-PD1:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2013/10/side-effects-of-nivolumab.html

                        I'm not sure how much these will help you…  I would certainly talk to my doc about how you are feeling, how often these mood swings happen and when.  Keeping a diary of events might help you and the doc figure things out.  Also, if brain mets have ever been an issue for you, and sadly I guess…even if they haven't, you do have to consider if any brain issue may be in play…though, hopefully, that is unlikely.

                        Hang in there.  Celeste

                         

                        • August 31, 2014 at 5:48 pm
                        ConstructionCM
                        Participant

                          Celeste and anyone else,

                           

                          Thank you for the update.  The advances in treatment within the past couple of years have been incredible.  I have Stage 4 melanoma and have just went through 4 infusions of Yervoy and just did my second of PD1.  Other than a rash,  I have not had that bad of side effects.  I have to say though that I occassionally get moody and have been more apt to lose my temper which is not my normal demeanor.  Have other people encountered that and does the meds impact your hormones?  Could this be part of what I am experiencing?  Thank you for your help!

                          Chris  

                        • August 31, 2014 at 4:30 am
                        BrianP
                        Participant

                          Thanks Celeste.

                      Viewing 2 reply threads
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