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  • Post
    • September 28, 2015 at 6:23 pm
    Debbieamccoy
    Participant

      I was diagnosed 3b may/15. Had WLI AND CLND . Only my sentinel biopsy was positive. I had perfectly clear scans on 8/18 on 8/26! I had my first round of yervoy. One week later I started n/v went to the ER and with my history a ct was done that showed probable mets to confirmed by biopsy. All of my liver enzymes are out of range ast 76 alt 284 and allk phos 278. My LDH is 5280. I started Keytruda last week but  I saw my dr this morning and he mentioned his concern st this rapid change of events occurred . I am too has any one else been threw this , I'm discouraged but stil fighting 

    Viewing 2 reply threads
    • Replies
        • September 28, 2015 at 6:29 pm
        dfeng
        Participant

          where is the met? Best wishes and pray for you. Hang in there and keep us updated!.

          • September 28, 2015 at 6:29 pm
          dfeng
          Participant

            where is the met? Best wishes and pray for you. Hang in there and keep us updated!.

            • September 28, 2015 at 6:29 pm
            dfeng
            Participant

              where is the met? Best wishes and pray for you. Hang in there and keep us updated!.

                • September 28, 2015 at 7:08 pm
                Debbieamccoy
                Participant

                  Mets to liver, I just found out my LDH dropped 800 points in one week after Keytruda round one . Staying hopeful

                  • September 28, 2015 at 7:08 pm
                  Debbieamccoy
                  Participant

                    Mets to liver, I just found out my LDH dropped 800 points in one week after Keytruda round one . Staying hopeful

                    • September 28, 2015 at 7:08 pm
                    Debbieamccoy
                    Participant

                      Mets to liver, I just found out my LDH dropped 800 points in one week after Keytruda round one . Staying hopeful

                      • September 28, 2015 at 7:36 pm
                      tschmith
                      Participant

                        Yes, stay hopeful!!!!!  800 points is a big drop.  Please keep us posted.  I've had terrific results with Keytruda and I bet you will too! (My LDH dropped afer my first infusion.)  

                        Best Wishes!!!!

                        Terrie

                         

                        • September 28, 2015 at 7:36 pm
                        tschmith
                        Participant

                          Yes, stay hopeful!!!!!  800 points is a big drop.  Please keep us posted.  I've had terrific results with Keytruda and I bet you will too! (My LDH dropped afer my first infusion.)  

                          Best Wishes!!!!

                          Terrie

                           

                          • September 28, 2015 at 7:36 pm
                          tschmith
                          Participant

                            Yes, stay hopeful!!!!!  800 points is a big drop.  Please keep us posted.  I've had terrific results with Keytruda and I bet you will too! (My LDH dropped afer my first infusion.)  

                            Best Wishes!!!!

                            Terrie

                             

                            • September 29, 2015 at 12:49 am
                            arthurjedi007
                            Participant

                              Sounds like the keytruda might already be helping which is great.

                              One thing you can ask the doc if you look it up and decide if you want is a liver embolism. This is usually reserved for large liver tumors so maybe not right for you. Dunno. One lady on here had that done for her daughter which gave an early good response followed up by immunotherapy that helped a lot too. They can also do radiation pellets directly on the liver tumors. Both of those require no trial that I'm aware of and the doc might probably be able to do them while on keytruda. Just some thoughts you might keep in mind if needed.

                              Artie

                              • September 29, 2015 at 12:49 am
                              arthurjedi007
                              Participant

                                Sounds like the keytruda might already be helping which is great.

                                One thing you can ask the doc if you look it up and decide if you want is a liver embolism. This is usually reserved for large liver tumors so maybe not right for you. Dunno. One lady on here had that done for her daughter which gave an early good response followed up by immunotherapy that helped a lot too. They can also do radiation pellets directly on the liver tumors. Both of those require no trial that I'm aware of and the doc might probably be able to do them while on keytruda. Just some thoughts you might keep in mind if needed.

                                Artie

                                • September 29, 2015 at 12:49 am
                                arthurjedi007
                                Participant

                                  Sounds like the keytruda might already be helping which is great.

                                  One thing you can ask the doc if you look it up and decide if you want is a liver embolism. This is usually reserved for large liver tumors so maybe not right for you. Dunno. One lady on here had that done for her daughter which gave an early good response followed up by immunotherapy that helped a lot too. They can also do radiation pellets directly on the liver tumors. Both of those require no trial that I'm aware of and the doc might probably be able to do them while on keytruda. Just some thoughts you might keep in mind if needed.

                                  Artie

                                  • September 29, 2015 at 8:50 pm
                                  Debbieamccoy
                                  Participant

                                    Now my dr has decided to put me on a combo yervoy and opvido

                                    https://www.futureofoncology.com/opdivoyervoy-combo-could-be-new-standard-in-melanoma

                                    im confused because I had progression of disease with one dose of yervoy. I've researched and can't find anything about restarting yervoy 

                                    • September 29, 2015 at 8:50 pm
                                    Debbieamccoy
                                    Participant

                                      Now my dr has decided to put me on a combo yervoy and opvido

                                      https://www.futureofoncology.com/opdivoyervoy-combo-could-be-new-standard-in-melanoma

                                      im confused because I had progression of disease with one dose of yervoy. I've researched and can't find anything about restarting yervoy 

                                      • September 29, 2015 at 8:50 pm
                                      Debbieamccoy
                                      Participant

                                        Now my dr has decided to put me on a combo yervoy and opvido

                                        https://www.futureofoncology.com/opdivoyervoy-combo-could-be-new-standard-in-melanoma

                                        im confused because I had progression of disease with one dose of yervoy. I've researched and can't find anything about restarting yervoy 

                                        • September 30, 2015 at 1:43 am
                                        Bubbles
                                        Participant

                                          If you read the post I put up regarding combination therapies it should make clear the difference between single therapies vs the results when they are combined…nivo/ipi in particular.  celeste

                                          • September 30, 2015 at 1:43 am
                                          Bubbles
                                          Participant

                                            If you read the post I put up regarding combination therapies it should make clear the difference between single therapies vs the results when they are combined…nivo/ipi in particular.  celeste

                                            • September 30, 2015 at 1:43 am
                                            Bubbles
                                            Participant

                                              If you read the post I put up regarding combination therapies it should make clear the difference between single therapies vs the results when they are combined…nivo/ipi in particular.  celeste

                                              • September 30, 2015 at 6:09 pm
                                              jpg
                                              Participant

                                                Usually if you progress on one or the other (IPI or NIVO) the combination isn't usually succesful.  I would ask the doctor too about this.  Lots of toxic side effects too.  Can't you just do the NIVO?  

                                                • September 30, 2015 at 6:09 pm
                                                jpg
                                                Participant

                                                  Usually if you progress on one or the other (IPI or NIVO) the combination isn't usually succesful.  I would ask the doctor too about this.  Lots of toxic side effects too.  Can't you just do the NIVO?  

                                                  • September 30, 2015 at 8:08 pm
                                                  Debbieamccoy
                                                  Participant

                                                    There are study's that show that even with progression to continue yervoy. 

                                                    • October 1, 2015 at 9:08 pm
                                                    tschmith
                                                    Participant

                                                      Debbie, 

                                                      Did they take you off of Yervoy after one dose?

                                                      Terrie

                                                      • October 1, 2015 at 9:08 pm
                                                      tschmith
                                                      Participant

                                                        Debbie, 

                                                        Did they take you off of Yervoy after one dose?

                                                        Terrie

                                                        • October 1, 2015 at 9:08 pm
                                                        tschmith
                                                        Participant

                                                          Debbie, 

                                                          Did they take you off of Yervoy after one dose?

                                                          Terrie

                                                          • October 1, 2015 at 9:10 pm
                                                          tschmith
                                                          Participant

                                                            I'm sorry…I reread your post and I see that you received just one dose.

                                                            Terrie

                                                            • October 1, 2015 at 9:10 pm
                                                            tschmith
                                                            Participant

                                                              I'm sorry…I reread your post and I see that you received just one dose.

                                                              Terrie

                                                              • October 1, 2015 at 9:10 pm
                                                              tschmith
                                                              Participant

                                                                I'm sorry…I reread your post and I see that you received just one dose.

                                                                Terrie

                                                                • October 2, 2015 at 2:34 am
                                                                Debbieamccoy
                                                                Participant

                                                                  Yes but they are restating it with nivo

                                                                  • October 2, 2015 at 2:34 am
                                                                  Debbieamccoy
                                                                  Participant

                                                                    Yes but they are restating it with nivo

                                                                    • October 2, 2015 at 2:34 am
                                                                    Debbieamccoy
                                                                    Participant

                                                                      Yes but they are restating it with nivo

                                                                      • September 30, 2015 at 8:08 pm
                                                                      Debbieamccoy
                                                                      Participant

                                                                        There are study's that show that even with progression to continue yervoy. 

                                                                        • September 30, 2015 at 8:08 pm
                                                                        Debbieamccoy
                                                                        Participant

                                                                          There are study's that show that even with progression to continue yervoy. 

                                                                          • September 30, 2015 at 6:09 pm
                                                                          jpg
                                                                          Participant

                                                                            Usually if you progress on one or the other (IPI or NIVO) the combination isn't usually succesful.  I would ask the doctor too about this.  Lots of toxic side effects too.  Can't you just do the NIVO?  

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