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Did your LDH levels go down as YERVOY responder?
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Did your LDH levels go down as YERVOY responder?

› Forums › General Melanoma Community › Did your LDH levels go down as YERVOY responder?

  • Post
    • January 10, 2015 at 9:19 pm
    Jacqueh27
    Participant

      My Daughters levels have gone from 8000 to 592 before her third infusion. She has liver tumor. She finished her fourth infusion last week and will have scans in four weeks. Any YERVOY responders have the same type of indicators it was working?

    Viewing 11 reply threads
    • Replies
        • January 10, 2015 at 10:16 pm
        Janner
        Participant

          Since the LDH is an indication of organ damage, I would think that type of improvement would be a positive sign.  Not everyone with liver mets has a high LDH, but to see improvement in those numbers isn't a bad thing.

          • January 10, 2015 at 10:16 pm
          Janner
          Participant

            Since the LDH is an indication of organ damage, I would think that type of improvement would be a positive sign.  Not everyone with liver mets has a high LDH, but to see improvement in those numbers isn't a bad thing.

            • January 10, 2015 at 10:16 pm
            Janner
            Participant

              Since the LDH is an indication of organ damage, I would think that type of improvement would be a positive sign.  Not everyone with liver mets has a high LDH, but to see improvement in those numbers isn't a bad thing.

              • January 11, 2015 at 4:46 am
              JustMeInCA
              Participant

                I've understood that when very high numbers go down quite a bit, that's a good sign. For some people, the numbers really never go too high despite what might be going on inside.

                • January 11, 2015 at 4:46 am
                JustMeInCA
                Participant

                  I've understood that when very high numbers go down quite a bit, that's a good sign. For some people, the numbers really never go too high despite what might be going on inside.

                  • January 11, 2015 at 4:46 am
                  JustMeInCA
                  Participant

                    I've understood that when very high numbers go down quite a bit, that's a good sign. For some people, the numbers really never go too high despite what might be going on inside.

                    • January 12, 2015 at 10:35 am
                    rick1981
                    Participant

                      For my wife LDH has always been a good indicator of response. Went from 2000 to 400 after starting with BRAF/MEK, stayed stable, then started to move to 1000 then 1300 – and yes the next scan showed significant disease progression. She is now on Keytruda (2 infusions, 3rd this Wednesday) and her LDH started to lower back to 600 right after the first so we HOPE it's a sign of reponse.

                      Good luck to your daughter – and you!

                      (PS. You've posted before right in the topic? 🙂 Just checking haha)

                      • January 12, 2015 at 10:35 am
                      rick1981
                      Participant

                        For my wife LDH has always been a good indicator of response. Went from 2000 to 400 after starting with BRAF/MEK, stayed stable, then started to move to 1000 then 1300 – and yes the next scan showed significant disease progression. She is now on Keytruda (2 infusions, 3rd this Wednesday) and her LDH started to lower back to 600 right after the first so we HOPE it's a sign of reponse.

                        Good luck to your daughter – and you!

                        (PS. You've posted before right in the topic? 🙂 Just checking haha)

                          • January 12, 2015 at 12:45 pm
                          Jacqueh27
                          Participant

                            Haha Rick yes, I didn't realize I did this anonymous. Thanks! Crossing fingers to scan. 

                            • January 12, 2015 at 12:45 pm
                            Jacqueh27
                            Participant

                              Haha Rick yes, I didn't realize I did this anonymous. Thanks! Crossing fingers to scan. 

                              • January 12, 2015 at 12:45 pm
                              Jacqueh27
                              Participant

                                Haha Rick yes, I didn't realize I did this anonymous. Thanks! Crossing fingers to scan. 

                              • January 12, 2015 at 10:35 am
                              rick1981
                              Participant

                                For my wife LDH has always been a good indicator of response. Went from 2000 to 400 after starting with BRAF/MEK, stayed stable, then started to move to 1000 then 1300 – and yes the next scan showed significant disease progression. She is now on Keytruda (2 infusions, 3rd this Wednesday) and her LDH started to lower back to 600 right after the first so we HOPE it's a sign of reponse.

                                Good luck to your daughter – and you!

                                (PS. You've posted before right in the topic? 🙂 Just checking haha)

                                • January 16, 2015 at 8:41 pm
                                Gene_S
                                Participant

                                  Hello,

                                  My husbands LDH levels were high when the disease was active and then dropped to a normal range and the doctor was thrilled and said this was a good sign that Yervoy was working.  Next his eyebrows started turning white and the doctor became more enthused.

                                  Yervoy worked for him and he has been NED for almost 2 1/2 years now.  Lets hope your daughter is also responding.  If you want to read more check out his profile.

                                  Judy (loving wife of Gene Stage IV and now NED)

                                  • January 16, 2015 at 8:41 pm
                                  Gene_S
                                  Participant

                                    Hello,

                                    My husbands LDH levels were high when the disease was active and then dropped to a normal range and the doctor was thrilled and said this was a good sign that Yervoy was working.  Next his eyebrows started turning white and the doctor became more enthused.

                                    Yervoy worked for him and he has been NED for almost 2 1/2 years now.  Lets hope your daughter is also responding.  If you want to read more check out his profile.

                                    Judy (loving wife of Gene Stage IV and now NED)

                                      • January 18, 2015 at 2:25 pm
                                      Jacqueh27
                                      Participant

                                        Thank you Judy! I sure hope thats what it means. She doesn't get her first scans for a few more weeks. I am so happy to hear that your husband is NED! God Bless! 

                                        • January 18, 2015 at 2:25 pm
                                        Jacqueh27
                                        Participant

                                          Thank you Judy! I sure hope thats what it means. She doesn't get her first scans for a few more weeks. I am so happy to hear that your husband is NED! God Bless! 

                                          • January 18, 2015 at 2:25 pm
                                          Jacqueh27
                                          Participant

                                            Thank you Judy! I sure hope thats what it means. She doesn't get her first scans for a few more weeks. I am so happy to hear that your husband is NED! God Bless! 

                                            • January 18, 2015 at 2:38 pm
                                            Jacqueh27
                                            Participant

                                              Judy, one more thing. How soon did your husbands hair start to turn white? Does this happen to most responders? 

                                              Thanks again. 

                                              Jacque 

                                              • January 18, 2015 at 2:38 pm
                                              Jacqueh27
                                              Participant

                                                Judy, one more thing. How soon did your husbands hair start to turn white? Does this happen to most responders? 

                                                Thanks again. 

                                                Jacque 

                                                • January 18, 2015 at 2:38 pm
                                                Jacqueh27
                                                Participant

                                                  Judy, one more thing. How soon did your husbands hair start to turn white? Does this happen to most responders? 

                                                  Thanks again. 

                                                  Jacque 

                                                  • January 19, 2015 at 2:47 pm
                                                  Gene_S
                                                  Participant

                                                    It was probably after the initial 4 doses (12 weeks) when he was in the maintenance phase where he received the infusions every 12 weeks but in his profile it is noted that the eyebrows, beard, and mustache were almost totally white by 6 months.

                                                    He says he wishes he had kept better notes as to the happenings but that is hindsight now.

                                                    Judy (loving wife of Gene)

                                                    • January 19, 2015 at 2:47 pm
                                                    Gene_S
                                                    Participant

                                                      It was probably after the initial 4 doses (12 weeks) when he was in the maintenance phase where he received the infusions every 12 weeks but in his profile it is noted that the eyebrows, beard, and mustache were almost totally white by 6 months.

                                                      He says he wishes he had kept better notes as to the happenings but that is hindsight now.

                                                      Judy (loving wife of Gene)

                                                      • January 19, 2015 at 5:17 pm
                                                      Jacqueh27
                                                      Participant

                                                        Thank you!

                                                        • January 19, 2015 at 5:17 pm
                                                        Jacqueh27
                                                        Participant

                                                          Thank you!

                                                          • January 20, 2015 at 2:03 pm
                                                          Gene_S
                                                          Participant

                                                            You are welcome and good luck.  Here is hoping that Yervoy is working.

                                                            Judy

                                                            • January 20, 2015 at 2:03 pm
                                                            Gene_S
                                                            Participant

                                                              You are welcome and good luck.  Here is hoping that Yervoy is working.

                                                              Judy

                                                              • January 20, 2015 at 2:03 pm
                                                              Gene_S
                                                              Participant

                                                                You are welcome and good luck.  Here is hoping that Yervoy is working.

                                                                Judy

                                                                • January 19, 2015 at 5:17 pm
                                                                Jacqueh27
                                                                Participant

                                                                  Thank you!

                                                                  • January 19, 2015 at 2:47 pm
                                                                  Gene_S
                                                                  Participant

                                                                    It was probably after the initial 4 doses (12 weeks) when he was in the maintenance phase where he received the infusions every 12 weeks but in his profile it is noted that the eyebrows, beard, and mustache were almost totally white by 6 months.

                                                                    He says he wishes he had kept better notes as to the happenings but that is hindsight now.

                                                                    Judy (loving wife of Gene)

                                                                  • January 16, 2015 at 8:41 pm
                                                                  Gene_S
                                                                  Participant

                                                                    Hello,

                                                                    My husbands LDH levels were high when the disease was active and then dropped to a normal range and the doctor was thrilled and said this was a good sign that Yervoy was working.  Next his eyebrows started turning white and the doctor became more enthused.

                                                                    Yervoy worked for him and he has been NED for almost 2 1/2 years now.  Lets hope your daughter is also responding.  If you want to read more check out his profile.

                                                                    Judy (loving wife of Gene Stage IV and now NED)

                                                                Viewing 11 reply threads
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