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Elevated liver function due to zelboraf
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Elevated liver function due to zelboraf

› Forums › General Melanoma Community › Elevated liver function due to zelboraf

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    • March 8, 2013 at 5:46 pm
    sgrain
    Participant
      Hi all. It’s been years since I’ve posted as I’ve been stage 3 since 1998. Now stage 4, lung nodule removed in right lung last year, now new tumors in right and left lungs. Did 3 months of yervoy and tumors spread in both lungs. Started zelboraf and after 8 days stopped due to severe rash. A week of steroids then half dose of zelboraf for a week. AST (liver functions) test went from 25 to 382 so now half of that dose (1 pill twice a day) and still have the rash. I have a pet scan next week and my question is, if liver function test still high and not much improvement, what is next?

      Hi all. It’s been years since I’ve posted as I’ve been stage 3 since 1998. Now stage 4, lung nodule removed in right lung last year, now new tumors in right and left lungs. Did 3 months of yervoy and tumors spread in both lungs. Started zelboraf and after 8 days stopped due to severe rash. A week of steroids then half dose of zelboraf for a week. AST (liver functions) test went from 25 to 382 so now half of that dose (1 pill twice a day) and still have the rash. I have a pet scan next week and my question is, if liver function test still high and not much improvement, what is next? Anyone know of good trials going on when both yervoy and zelboraf fail? Getting really scared now.

      Much luck to all in beating this thing?

      Sandy

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