fever and chills from dabrafenib and trametinib

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fever and chills from dabrafenib and trametinib

This topic has 2 replies, 2 voices, and was last updated 4 years, 11 months ago by MelMel.

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- July 3, 2020 at 4:49 pm
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[email protected]
Participant
I have been taking the meds for 13 weeks and due to the fever and chills after taking the medication I had to stop twice.. But currently back on the meds I continue to have fever and chills for one to two hours 4 to 5 hrs after taking the medication.
I came to this group to see what specific procedures have helped to address fever and chills
I and currently taking 650 mg of Tylenol 1 hr before each of the two daily doses of medication. I have also been advised that 5 mg of prednisone is also available to curb the fever
I have stage 4 lung cancer with braf 600 e and without the medication the disease will progress. For the first two months the tumor reduced 30%. But with continuation of fever and chills I am struggling
Given that Melanoma has a much longer history, research backing it and clinical knowledge compared to the Veterans administration in San Diego where I am the only patient with Braf 600e lung cancer and research is limited. The excellent medical staff have reached out to the melanoma staff for feedback but I am also requesting your help because you are and have been in the trenches for long time and may have pertinent information to address this critical concern.

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- - July 3, 2020 at 10:18 pm
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  Bubbles
  Participant
  Sorry for what you are going through, Michael. There are many targeted therapy warriors on this forum and I’m sure they will chime in. Here is a post (with links within) that addresses side effects to targeted therapy, specifically fever, and how to deal with them: https://chaoticallypreciselifeloveandmelanoma.blogspot.com/2017/05/management-of-adverse-events-with.html
  
  Hope you find some relief soon. I wish you my best. celeste
- - July 5, 2020 at 2:34 am
  - Quote
  MelMel
  Participant
  So sorry to hear that you need to be here and I certainly wish you only the best. My brother in law was battling pancreatic cancer at the VA in Ann Arbor, Michigan.
  Celeste has excellent advice to which I would just like to add my own experience for whatever it is worth. If it will not help you, I am certain it will not make things worse. While I was experiencing temperature episodes during my immunotherapy I had used cold towels drenched in cold water as well as a solution of water and apple cider vinegar. You can use regular white vinegar as well. My mom helped me apply them to my forehead, neck, chest, thighs. She would change these every 10-15 minutes. I know it sounds crazy but it worked. We did this for about 5-6 hrs at a time while my fever raged. Luckily after three or four days the fever went away.
  Best wishes,
  Melanie

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