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First Therapy & Diarreah
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First Therapy & Diarreah

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    • April 14, 2019 at 4:22 pm
    Carlsbad317
    Participant

      First treatment of the combo was 6 weeks ago. Five days after relentless diarrhea took over. Steadily increased steroids up to 80, am due out everything on pause. Now Some days none other days, greater than 5 times. Can’t seem to drop below 40 on the steroids or the relentless returns.  Doing an IV tomorrow of meds to prevent the diarrhea – praying it works.  Any experience with this? 

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        • April 14, 2019 at 9:14 pm
        Edwin
        Participant

          For me diarrhea was the worst side effect from Yervoy + Opdivo immunotherapy.   It lasted from April 2016 to September 2016, gradually becoming not as bad.  I took Prednisone and Imodium for it.   Sometimes I did not make it in time from my bed to the toilet.  For a few weeks I wore adult diapers at night and when I was more than 2 minutes from a restroom.   I missed work for weeks, because the restroom was too far from my office.

            • April 15, 2019 at 2:19 am
            Carlsbad317
            Participant

              Thank you for sharing.  I am going to ask about the Imodium.  And the Depends have been a god send.

              • April 15, 2019 at 1:25 pm
              Edwin
              Participant

                My oncologist’s nurse Kim telephoned me several times to see how I was doing in the first 2 weeks after I began Yervoy + Opdivo immunotherapy.   Oxycodone can cause constipation.   I thought of taking Oxycodone to treat diarrhea as well as pain.  Kim convinced me that that was a bad idea.  I should take Oxycodone, only when Tylenol did not give adequate pain relief.  I followed Kim's advice.

              • April 15, 2019 at 8:07 pm
              Rexpo
              Participant

                i went through this, had diarrhea about 15 times a day beginning ten days after first treatment of IPI/NIVO.  Spent a month at home on massive steroids, then 3 weeks in the hospital attempting to rest my colon.  Ended up with a colectomy. 

                What you are going through is really serious stuff, make sure you speak with your oncologist and encourage him/her to have you see a GI specialist and get a flex sigmoidoscopy.

                Surgery saved my life, hopefully it won't come to that with you!

                  • April 16, 2019 at 3:17 am
                  Carlsbad317
                  Participant

                    Thank you for sharing, oh my goodness.  I will speak with them tomorrow.

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