I'm a little surprised to hear that.  When I was researching clinical trials a few months ago I heard pretty positive things from patients and caregivers about the results they were getting at Moffitt.  (Clinical trial NCT01437605 ).

I'm a little surprised to hear that.  When I was researching clinical trials a few months ago I heard pretty positive things from patients and caregivers about the results they were getting at Moffitt.  (Clinical trial NCT01437605 ).

I'm a little surprised to hear that.  When I was researching clinical trials a few months ago I heard pretty positive things from patients and caregivers about the results they were getting at Moffitt.  (Clinical trial NCT01437605 ).

They are trying to determine what biomarkers might exist so that they can cherry pick the people most likely to gain a benefit.

I'm in that trial and the news is disappointing to say the LEAST!

In 2012 I had asked my doctor what rumors he had heard at ASCO 2012 about how patients in the trial were doing. His reply to me was that he heard that patients on both arms were doing well. In the back of my mind I kept wondering about how they will be able to determine the vaccine's effectiveness if that was the case. But what the heck do I know? I'm not a medical professional. Maybe they just needed more time.

Perhaps they'll meet their secondary endpoint? Who knows!

I'm in that trial and the news is disappointing to say the LEAST!

In 2012 I had asked my doctor what rumors he had heard at ASCO 2012 about how patients in the trial were doing. His reply to me was that he heard that patients on both arms were doing well. In the back of my mind I kept wondering about how they will be able to determine the vaccine's effectiveness if that was the case. But what the heck do I know? I'm not a medical professional. Maybe they just needed more time.

Perhaps they'll meet their secondary endpoint? Who knows!

I'm in that trial and the news is disappointing to say the LEAST!

In 2012 I had asked my doctor what rumors he had heard at ASCO 2012 about how patients in the trial were doing. His reply to me was that he heard that patients on both arms were doing well. In the back of my mind I kept wondering about how they will be able to determine the vaccine's effectiveness if that was the case. But what the heck do I know? I'm not a medical professional. Maybe they just needed more time.

Perhaps they'll meet their secondary endpoint? Who knows!

Hi Brian,

No, I'm at Hopkins.

From what I understood, the Phase II trial results were not too shabby. I guess that based on that, GSK had high hopes for the vaccine for Phase III.

There were several other patients at Hopkins besides me who were on the trial. I never thought to ask Dr. Scharfmann if any of them had recurrences. I met one in the waiting area on the day she got her final injection and obviously she had not had a recurrence. I just had my final injection in April and so far, so good. Of course I don't know if I had the placebo or the vaccine but I did experience some of the side effects reported by other folks in the trial.

I'm not sure what they were looking for in terms of numbers/percentages for the primary endpoint. But what I can't get out of the back of my mind is, how much worse can those number be in comparison to the numbers for interferon's effectiveness?

Another question in the back of my mind is how much of these numbers could have been affected by the injections being given incorrectly? I'd read an article a while back on how something as simple as that can have an effect on trial results.

There was a lady in this forum who was in the trial and had a recurrence. I think her name was Carol. I haven't seen any posts by her in a while.

I'm still in the Mage Trial at Moffitt.  Dr. Weber tells me his trial results appear to be good. However, it could be a statistical anomaly based on a small number of people in the trial.   I'm one year into the trial and still NED.  This trial is for Stage IV ressected tumor patients.  I only had one met in my chest and an SNB.  Not sure how long I would have been NED without the trial. I certainly wouldn't put any judgement into this trial program until the stage is complete and the results are published. 

Dr. Weber is amazing.   He tells it like it is, no sugar coating.  I'm very happy with the trial and with Moffitt based upon my situation. 

My plan is that if a tumor appears, I'll work with Dr. Weber on another program and just keep throwing up roadblocks in the event that a cure appears on the horizon in in the next five years.  We are all simply buying time… enjoy every moment. 

Hey Linny,

Are you at Moffitt?  When I was looking at enrolling in the trial I spoke with Dr. Weber and he was very positive about the trial.  In fact I remember him making a comment that he had spoken with the sponsor about trying to start a anti PD1 and Mage combo trial because he was so pleased with the results so far in the Mage trial.  If my memory serves me, at that time (around may/june) of about 12 patients in the trial at Moffitt only two had a reccurence.  Granted the trial hadn't been going on that long but that still seemed pretty good to me.  I know Frank on this forum is enrolled in that trial at Moffitt.  Sometimes he logs on.  I'd be curious if he's had any updates on the trial success down there.

Brian

Hey Linny,

Are you at Moffitt?  When I was looking at enrolling in the trial I spoke with Dr. Weber and he was very positive about the trial.  In fact I remember him making a comment that he had spoken with the sponsor about trying to start a anti PD1 and Mage combo trial because he was so pleased with the results so far in the Mage trial.  If my memory serves me, at that time (around may/june) of about 12 patients in the trial at Moffitt only two had a reccurence.  Granted the trial hadn't been going on that long but that still seemed pretty good to me.  I know Frank on this forum is enrolled in that trial at Moffitt.  Sometimes he logs on.  I'd be curious if he's had any updates on the trial success down there.

Brian

Hey Linny,

Are you at Moffitt?  When I was looking at enrolling in the trial I spoke with Dr. Weber and he was very positive about the trial.  In fact I remember him making a comment that he had spoken with the sponsor about trying to start a anti PD1 and Mage combo trial because he was so pleased with the results so far in the Mage trial.  If my memory serves me, at that time (around may/june) of about 12 patients in the trial at Moffitt only two had a reccurence.  Granted the trial hadn't been going on that long but that still seemed pretty good to me.  I know Frank on this forum is enrolled in that trial at Moffitt.  Sometimes he logs on.  I'd be curious if he's had any updates on the trial success down there.

Brian

Hi Brian,

No, I'm at Hopkins.

From what I understood, the Phase II trial results were not too shabby. I guess that based on that, GSK had high hopes for the vaccine for Phase III.

There were several other patients at Hopkins besides me who were on the trial. I never thought to ask Dr. Scharfmann if any of them had recurrences. I met one in the waiting area on the day she got her final injection and obviously she had not had a recurrence. I just had my final injection in April and so far, so good. Of course I don't know if I had the placebo or the vaccine but I did experience some of the side effects reported by other folks in the trial.

I'm not sure what they were looking for in terms of numbers/percentages for the primary endpoint. But what I can't get out of the back of my mind is, how much worse can those number be in comparison to the numbers for interferon's effectiveness?

Another question in the back of my mind is how much of these numbers could have been affected by the injections being given incorrectly? I'd read an article a while back on how something as simple as that can have an effect on trial results.

There was a lady in this forum who was in the trial and had a recurrence. I think her name was Carol. I haven't seen any posts by her in a while.

Hi Brian,

No, I'm at Hopkins.

From what I understood, the Phase II trial results were not too shabby. I guess that based on that, GSK had high hopes for the vaccine for Phase III.

There were several other patients at Hopkins besides me who were on the trial. I never thought to ask Dr. Scharfmann if any of them had recurrences. I met one in the waiting area on the day she got her final injection and obviously she had not had a recurrence. I just had my final injection in April and so far, so good. Of course I don't know if I had the placebo or the vaccine but I did experience some of the side effects reported by other folks in the trial.

I'm not sure what they were looking for in terms of numbers/percentages for the primary endpoint. But what I can't get out of the back of my mind is, how much worse can those number be in comparison to the numbers for interferon's effectiveness?

Another question in the back of my mind is how much of these numbers could have been affected by the injections being given incorrectly? I'd read an article a while back on how something as simple as that can have an effect on trial results.

There was a lady in this forum who was in the trial and had a recurrence. I think her name was Carol. I haven't seen any posts by her in a while.

I'm still in the Mage Trial at Moffitt.  Dr. Weber tells me his trial results appear to be good. However, it could be a statistical anomaly based on a small number of people in the trial.   I'm one year into the trial and still NED.  This trial is for Stage IV ressected tumor patients.  I only had one met in my chest and an SNB.  Not sure how long I would have been NED without the trial. I certainly wouldn't put any judgement into this trial program until the stage is complete and the results are published. 

Dr. Weber is amazing.   He tells it like it is, no sugar coating.  I'm very happy with the trial and with Moffitt based upon my situation. 

My plan is that if a tumor appears, I'll work with Dr. Weber on another program and just keep throwing up roadblocks in the event that a cure appears on the horizon in in the next five years.  We are all simply buying time… enjoy every moment. 

I'm still in the Mage Trial at Moffitt.  Dr. Weber tells me his trial results appear to be good. However, it could be a statistical anomaly based on a small number of people in the trial.   I'm one year into the trial and still NED.  This trial is for Stage IV ressected tumor patients.  I only had one met in my chest and an SNB.  Not sure how long I would have been NED without the trial. I certainly wouldn't put any judgement into this trial program until the stage is complete and the results are published. 

Dr. Weber is amazing.   He tells it like it is, no sugar coating.  I'm very happy with the trial and with Moffitt based upon my situation. 

My plan is that if a tumor appears, I'll work with Dr. Weber on another program and just keep throwing up roadblocks in the event that a cure appears on the horizon in in the next five years.  We are all simply buying time… enjoy every moment.