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High Liver Count
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High Liver Count

› Forums › General Melanoma Community › High Liver Count

  • Post
    • May 8, 2017 at 6:23 pm
    newmanmark
    Participant

      Hello,

      I am on Nivolumab and was doing well with it.  My latest bloodwork showed elevated AST and ALT levels.  The doctor has taken me off of treatment and put me on steroids in an effort to bring the levels back down.  I was wondering if anyone with a similar experience was able to get back on treatment after the steroids were successful in returning your liver levels back to normal?

      Mark

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    • Replies
        • May 8, 2017 at 8:30 pm
        MikeW
        Participant

          I don't have answers…I'm in the same boat right now on pembro but I thought I'd pass along my story and keep you posted….my liver enzymes 'inched up'…took steriods and it came down in 5 days and now I'm tapering off steriods. I'll do another blood lab tomorrow and we'll re-assess. 

          My doc said…this means we've activated your immune system so that's a good thing. I may have to wait until the first scan in two more weeks before we get back on the therapy.  I've heard other folks go back on afterwards. 

          • May 8, 2017 at 11:00 pm
          ed williams
          Participant

            How high were the levels Mark?

            • May 8, 2017 at 11:46 pm
            Ridingaroundwith27Jennifers
            Participant

              I had elevated AST and ALT levels after my second combiation treatment with Ipi/Nivo.  I was on steroids and cellcept to bring the numbers down.  I'm on only Nivolumab treatments now.  Not exactly the same but similar.  It took about 3 months to get my liver numbers down however they have been good so far and I just had my third Nivo treatment today.  Dr. Buchbinder said usually there is a 50% chance the liver will react upon restarting treatment but there is no way to tell who will react again.  She had also told me that sometimes patients don't need to restart treatment.  Hopefully you are in this group.  

              • May 9, 2017 at 1:51 am
              Casitas1
              Participant
                Hey Mark, I made it through 2 combo treatments before autoimmune pancreatitis. Was on steroids 6 weeks. We tried Nivo. alone but only made it through 2 single doses due to liver counts at 1000 over ten times normal back on steroids 6 weeks. Switched to Pembro after 4 weeks of low dose chemo and had complete response with normal liver counts… Best,Paul
                • May 10, 2017 at 7:16 am
                raun cesar
                Participant

                  To bring down the AST and ALT levels steroids are good, thought they will take time combined with nevo treatment my doc is confident with the progress

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