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how long i need stop Combo Braf/Mek to show progression in Pet/scan?
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how long i need stop Combo Braf/Mek to show progression in Pet/scan?

› Forums › General Melanoma Community › how long i need stop Combo Braf/Mek to show progression in Pet/scan?

  • Post
    • July 26, 2014 at 11:47 am
    jualonso
    Participant

      Hi folks,

      Finally i have decided to stop with combo, i was talking with my doc about to start

      Mek anti pd1, but the condition is to progress on ipi or braf inhibitors, then the only option i have is to stop taking pills before the next PetScan and show progression in it (now in NED)

      Is a very tought decision but i dont have any other option if i want to avoid resistance and still keep these drugs with pottencial for the future.

      I would be very gratefull any help from someone who has follow the same path

       

      Juan

      .

    Viewing 8 reply threads
    • Replies
        • July 26, 2014 at 6:53 pm
        andy123
        Participant

          Juan,

          why not try 1 or 2 rounds of IPI since you are already NED ( as you made aware – at this year's asco they showed impressive results with adjuvant IPI , albeit with some toxicities).

          if it works, great ( one of the anti-pd1 will anyway get approved by end of the year and you can go on to it later) and if it does not, it qualifies you for the anti-pd1.

          It is  just a thought. 

           

           

          • July 26, 2014 at 6:53 pm
          andy123
          Participant

            Juan,

            why not try 1 or 2 rounds of IPI since you are already NED ( as you made aware – at this year's asco they showed impressive results with adjuvant IPI , albeit with some toxicities).

            if it works, great ( one of the anti-pd1 will anyway get approved by end of the year and you can go on to it later) and if it does not, it qualifies you for the anti-pd1.

            It is  just a thought. 

             

             

            • July 26, 2014 at 6:53 pm
            andy123
            Participant

              Juan,

              why not try 1 or 2 rounds of IPI since you are already NED ( as you made aware – at this year's asco they showed impressive results with adjuvant IPI , albeit with some toxicities).

              if it works, great ( one of the anti-pd1 will anyway get approved by end of the year and you can go on to it later) and if it does not, it qualifies you for the anti-pd1.

              It is  just a thought. 

               

               

              • July 26, 2014 at 7:35 pm
              tcell
              Participant

                I have just progressed on BRAF / Mek after five months, no dose reduction or any other action needed, just resistant now.

                I have  a high tumor burden and will start Ipi now.

                Juan, there is one thing I keep reading in your posts which I find quite astonishing.

                Merck Anti-Pd1 EAP if this is what you are aiming at is also avilable here in Austria. As all patients in the US as well as other European xountries the condition here is to have faild BRAF / MEK if applicable AND to have failed Ipi. Now I am wondering why exactly in Spain these xonsitions should be different than anywhere else. What you are saying is that it is enough to have failed one of the two which does not seem logical to me at all.

                just to say that I would really recommend you carefully recheck this information before relying on it.

                all the best,

                Chris

                • July 26, 2014 at 7:35 pm
                tcell
                Participant

                  I have just progressed on BRAF / Mek after five months, no dose reduction or any other action needed, just resistant now.

                  I have  a high tumor burden and will start Ipi now.

                  Juan, there is one thing I keep reading in your posts which I find quite astonishing.

                  Merck Anti-Pd1 EAP if this is what you are aiming at is also avilable here in Austria. As all patients in the US as well as other European xountries the condition here is to have faild BRAF / MEK if applicable AND to have failed Ipi. Now I am wondering why exactly in Spain these xonsitions should be different than anywhere else. What you are saying is that it is enough to have failed one of the two which does not seem logical to me at all.

                  just to say that I would really recommend you carefully recheck this information before relying on it.

                  all the best,

                  Chris

                    • July 26, 2014 at 9:16 pm
                    jualonso
                    Participant

                       

                      http://www.groupgem.org/ensayos/2014/ensayos-clinicos-activos-en-espana/

                      Hi Chris,

                      Visit this web and download the file 

                      Estudios melanoma 26 mayo 2014 ipi

                      On page 41 you will be able to read in spanish, Mk3475 compassionate use and also 2 nd line, not 3 rd line, and post IPI OR POST BRAF INH. not and….

                      Anyway, i will check with my doc because for me is also very strange. It must a a mistake.

                      Juan

                      • July 26, 2014 at 9:16 pm
                      jualonso
                      Participant

                         

                        http://www.groupgem.org/ensayos/2014/ensayos-clinicos-activos-en-espana/

                        Hi Chris,

                        Visit this web and download the file 

                        Estudios melanoma 26 mayo 2014 ipi

                        On page 41 you will be able to read in spanish, Mk3475 compassionate use and also 2 nd line, not 3 rd line, and post IPI OR POST BRAF INH. not and….

                        Anyway, i will check with my doc because for me is also very strange. It must a a mistake.

                        Juan

                        • July 27, 2014 at 9:18 am
                        tcell
                        Participant

                          I think this is a good idea to recheck. If he is not sure let him contact Merck again directly for a writtentatement.

                          Imagine you base such important dicisions as about your treatment path on a translation mistake!

                          • July 27, 2014 at 9:18 am
                          tcell
                          Participant

                            I think this is a good idea to recheck. If he is not sure let him contact Merck again directly for a writtentatement.

                            Imagine you base such important dicisions as about your treatment path on a translation mistake!

                            • July 27, 2014 at 9:18 am
                            tcell
                            Participant

                              I think this is a good idea to recheck. If he is not sure let him contact Merck again directly for a writtentatement.

                              Imagine you base such important dicisions as about your treatment path on a translation mistake!

                              • July 26, 2014 at 9:16 pm
                              jualonso
                              Participant

                                 

                                http://www.groupgem.org/ensayos/2014/ensayos-clinicos-activos-en-espana/

                                Hi Chris,

                                Visit this web and download the file 

                                Estudios melanoma 26 mayo 2014 ipi

                                On page 41 you will be able to read in spanish, Mk3475 compassionate use and also 2 nd line, not 3 rd line, and post IPI OR POST BRAF INH. not and….

                                Anyway, i will check with my doc because for me is also very strange. It must a a mistake.

                                Juan

                                • July 26, 2014 at 9:26 pm
                                jualonso
                                Participant

                                  Chris,

                                  One question, did you feel that tumors are growing now faster than before taking Combo?

                                  Thanks and good luck with Ipi, i hope reduce as much as possible your tumor burden

                                   

                                  • July 26, 2014 at 9:26 pm
                                  jualonso
                                  Participant

                                    Chris,

                                    One question, did you feel that tumors are growing now faster than before taking Combo?

                                    Thanks and good luck with Ipi, i hope reduce as much as possible your tumor burden

                                     

                                    • July 27, 2014 at 9:15 am
                                    tcell
                                    Participant

                                      Couldn't tell really. I feel that what I have is generally a very aggressive and active type. I don't know how fast it had grown before as I don't know when it had started to grow but now my feeling is that it is certainly not slow.

                                      • July 27, 2014 at 9:15 am
                                      tcell
                                      Participant

                                        Couldn't tell really. I feel that what I have is generally a very aggressive and active type. I don't know how fast it had grown before as I don't know when it had started to grow but now my feeling is that it is certainly not slow.

                                        • July 27, 2014 at 9:15 am
                                        tcell
                                        Participant

                                          Couldn't tell really. I feel that what I have is generally a very aggressive and active type. I don't know how fast it had grown before as I don't know when it had started to grow but now my feeling is that it is certainly not slow.

                                          • July 26, 2014 at 9:26 pm
                                          jualonso
                                          Participant

                                            Chris,

                                            One question, did you feel that tumors are growing now faster than before taking Combo?

                                            Thanks and good luck with Ipi, i hope reduce as much as possible your tumor burden

                                             

                                          • July 26, 2014 at 7:35 pm
                                          tcell
                                          Participant

                                            I have just progressed on BRAF / Mek after five months, no dose reduction or any other action needed, just resistant now.

                                            I have  a high tumor burden and will start Ipi now.

                                            Juan, there is one thing I keep reading in your posts which I find quite astonishing.

                                            Merck Anti-Pd1 EAP if this is what you are aiming at is also avilable here in Austria. As all patients in the US as well as other European xountries the condition here is to have faild BRAF / MEK if applicable AND to have failed Ipi. Now I am wondering why exactly in Spain these xonsitions should be different than anywhere else. What you are saying is that it is enough to have failed one of the two which does not seem logical to me at all.

                                            just to say that I would really recommend you carefully recheck this information before relying on it.

                                            all the best,

                                            Chris

                                            • July 30, 2014 at 7:58 am
                                            fortiz
                                            Participant
                                              Check the trial again, becouse I think than to stop the combo while you are NED is not the same than to have failed on it.
                                              • July 30, 2014 at 7:58 am
                                              fortiz
                                              Participant
                                                Check the trial again, becouse I think than to stop the combo while you are NED is not the same than to have failed on it.
                                                • July 30, 2014 at 7:58 am
                                                fortiz
                                                Participant
                                                  Check the trial again, becouse I think than to stop the combo while you are NED is not the same than to have failed on it.
                                              Viewing 8 reply threads
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