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IPI/Nivo side effects – Prednisone yes or no ?
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IPI/Nivo side effects – Prednisone yes or no ?

› Forums › General Melanoma Community › IPI/Nivo side effects – Prednisone yes or no ?

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    • October 14, 2019 at 5:51 pm
    sks2019
    Participant
      Back here again as I see my mom struggling everyday since she started the combo. As I have been asking folks about their experiences about jaw aches , temporal and facial aches.
      her doc prescribed her prednisone. She is prescribed 10mg daily. prednisone gives her energy to get herself out of bed but the jaw numbness stays.

      Without the prednisone she cant get out of the bed. I have searched this forum to get information but I feel i get mixed responses.
      How does prednisone impacts the combo drugs ? or does it impacts at all ? Should she try to avoid it if possible ? She says I can bear the pain if it helps to get the combo doing what it is supposed to do.
      She doesnt want to interrupt the combo effectiveness with the prednisone.

      thanks for reading this patiently and Hope GOD helps us all.

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    • Replies
        • October 14, 2019 at 6:09 pm
        Edwin
        Participant
          I took prednisone to help recover after my first ipi:nivo infusion. I was able to complete all 4 combo infusions. I had melanoma in many bones. Ipi:nivo immunotherapy put my bone cancer into remission.
            • October 14, 2019 at 9:15 pm
            sks2019
            Participant
              Thanks Edwin. This is reassuring, we are hoping for the positive outcome.
            • October 14, 2019 at 6:14 pm
            mandyjill
            Participant
              I started taking prednisone, 10 mg. per day, after about 6 months on the combo for fatigue and bad joint and bone pain. It helped tremendously. My doctor said it wasn’t enough strength to affect the potency of the cancer drugs. I have been NED for about 2.5 years.
                • October 14, 2019 at 9:16 pm
                sks2019
                Participant
                  That’s great mandyjill. Wishing you continued NED status.
                • October 14, 2019 at 8:29 pm
                Bubbles
                Participant
                  No one should take meds they don’t need. However, side effects due to immunotherapy often necessitate steroids and other “immunosuppressive” drugs in order for patients to deal with them and continue needed therapy. Data has long shown that side effects can and should be treated. Further, even when steroids are used to do so, patients still respond to therapy – as noted in this report from 2018 (with many links to other reports within….going back to 2015): https://chaoticallypreciselifeloveandmelanoma.blogspot.com/2018/02/for-jubesand-rest-of-us-anti-rheumatic.html

                  c

                    • October 14, 2019 at 9:20 pm
                    sks2019
                    Participant
                      Thanks for responding and links to those articles Celeste ! Now I am just thinking having some common side effects would have made our lives just a little better. Seeing something unexpected just puts me into the worry mode. So grateful for all your collected stats and sharing it , documenting it for the folks here. This is a great service.
                    • October 17, 2019 at 10:35 pm
                    MelanomaMike
                    Participant
                      Hi sis, a little late to reply here, been feeling “Blah” myself with my own “combo” of incmga00012 & Epacadostat. My only issue i had personally with the Ipi/Nivo combo was 6 days after my very first infuse, my Pituitary gland was country fried, it brought on severe vomiting, headpounding throbs when i got up & down, appetite was ZERO (lost 20lbs in 15 days) i finally got help with Megace (my wife brought some home for me) an appetite stimulant, that alone made me feel better cuz i was Eating again within 48hrs! Once i finally came in for my next bloodwork, it was then they found no Cortisil was being produced and my new Endo doc started me on Hydrocortisone pills, 10mg AM/10mg 3pm been great ever since, i was able to complete the other 3 Yervoys without any side effects…
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