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Late (>1yr) cutaneous adverse events to PD-1 Keytruda
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Late (>1yr) cutaneous adverse events to PD-1 Keytruda

› Forums › Cutaneous Melanoma Community › Late (>1yr) cutaneous adverse events to PD-1 Keytruda

  • Post
    • November 8, 2017 at 12:39 am
    Spl25
    Participant

      Has anyone had really late onset of rash/blistering etc.? Any idea why now or what this means as far as treatment goes?

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    • Replies
        • November 8, 2017 at 2:50 am
        LHiner50
        Participant

          After three Keytruda treatments I  had a severe rash on legs and arms which was cleared up with prednisone.  About six weeks later vitiligo started on legs and arms also.  Treatment was stopped and the last three scans have been stable.  I had nivo/Yervoy previously and had two reactions.  I respond well to immunotherapy but it "overstimulates" my immune system.  It seems the vitiligo issue is a good sign that the Keytruda continues to work – let's hope.  Hope your rash clears up and can continue with treatment,

          • November 8, 2017 at 3:39 am
          TexMelanomex
          Participant

            I have also read (and I believe bubbles has some solid data on her blog) about rashes and vitiligo being positively prognostic for responding to immunotherapy. I recently completed only my second dose of Keytruda and had a brief rash the first time (which might have been due to the additional treatment with PV-10), and no skin symptoms the second time around (about 7 days ago now). I have had some flu like symptoms and fatigue (both fairly mild) which resolved within days of the treatment, but again I am new to the treatment. So, are you experiencing this after one year of treatment or one year after finishing treatment?

             

              • November 8, 2017 at 5:12 am
              Spl25
              Participant

                After one year of receiving treatment, which strikes me as odd because I usually see stories of early onset cutaneous AE, not after a full year.

              • November 8, 2017 at 2:44 pm
              Bubbles
              Participant

                We have learned that late response….esp "late" side effects are actually fairly common with immunotherapy.

                Here is a post and report from experts in 2015 (check out the top section of points with an asterisk): 

                 http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/09/side-effects-and-how-to-manage-them-in.html

                Celeste

                  • November 8, 2017 at 4:59 pm
                  Spl25
                  Participant

                    Thanks Celeste — you’re a wizard!

                  • November 9, 2017 at 5:41 am
                  Casitas1
                  Participant

                    I have been NED 16 months and off treatment (Keytruda) for one year now. about a month ago i had joint pain increase and Pancreatitis  flare up. Those i had during treatment. a wierd rash as well was new groin area and under left arm. Maybe my immune system is permanantly rigged this way? Not complaining though.
                    Best, Paul

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