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LDH Levels

Forums General Melanoma Community LDH Levels

  • Post
    JoshF
    Participant
      Hi was wondering if I should be concerned as my LDH level went from 139 to 174 in 6 months. I’ve heard this is a marker for metastasis. Can someone answer?
    Viewing 5 reply threads
    • Replies
        ecc26
        Participant

          I can't recall the normal range off the top of my head, but your values don't strike me as very high and if you're within the normal range I wouldn't worry about it. All of your bloodwork values will fluctuate a little from time to time- if you went back and tested again a week later it might have gone down again. As long as it stays within the range of "normal" I don't think there's any cause for concern. 

          LDH is a bit crude as an indicator for metastases anyway. It is true that often people with mets (and generally a high number of them) will have elevated LDH, it is not always the case- I have close to 40 mets and my LDH has never been even remotely elevated. LDH itself is released into the blood most commonly with tissue damage or turnover, which is why it can be elevated in people with mets (the tumors damage the tissue as they grow, etc). However, going for an extra long run the day before you get your blood drawn and having sore muscles could also potentially create a slight increase over whatever your last values were. As I said before- ANY of the values on your bloodwork will fluctuate up and down some, rarely will they be the same twice (your BUN and creatinine indicators for your kidneys will rise dramatically if you happen to be a little dehydrated that day but it doesn't mean your kidney's are failing). As long as you remain inside the normal range it's not likely anything to be worry about. 

          -eva

            Erinmay22
            Participant

              As mentiond, I don't think that is anything to worry about.  LDH can be an indicator, but doesn't confirm Melanoma.  And those #s are in the range.   There are other things that can also affect your LDH (i.e. if you're recently worked out – muscle injury).  

              Some folks will see there's doulbe/triple etc.  I think that for Sloan the range goes up to maybe 246 or something like that.  I wouldn't worry about it.  Not sure what stage you are, but if you're getting regular checks, a change like that in 6 months wouldn't cause much concern to me.

              Erin

              Erinmay22
              Participant

                As mentiond, I don't think that is anything to worry about.  LDH can be an indicator, but doesn't confirm Melanoma.  And those #s are in the range.   There are other things that can also affect your LDH (i.e. if you're recently worked out – muscle injury).  

                Some folks will see there's doulbe/triple etc.  I think that for Sloan the range goes up to maybe 246 or something like that.  I wouldn't worry about it.  Not sure what stage you are, but if you're getting regular checks, a change like that in 6 months wouldn't cause much concern to me.

                Erin

                Erinmay22
                Participant

                  As mentiond, I don't think that is anything to worry about.  LDH can be an indicator, but doesn't confirm Melanoma.  And those #s are in the range.   There are other things that can also affect your LDH (i.e. if you're recently worked out – muscle injury).  

                  Some folks will see there's doulbe/triple etc.  I think that for Sloan the range goes up to maybe 246 or something like that.  I wouldn't worry about it.  Not sure what stage you are, but if you're getting regular checks, a change like that in 6 months wouldn't cause much concern to me.

                  Erin

                ecc26
                Participant

                  I can't recall the normal range off the top of my head, but your values don't strike me as very high and if you're within the normal range I wouldn't worry about it. All of your bloodwork values will fluctuate a little from time to time- if you went back and tested again a week later it might have gone down again. As long as it stays within the range of "normal" I don't think there's any cause for concern. 

                  LDH is a bit crude as an indicator for metastases anyway. It is true that often people with mets (and generally a high number of them) will have elevated LDH, it is not always the case- I have close to 40 mets and my LDH has never been even remotely elevated. LDH itself is released into the blood most commonly with tissue damage or turnover, which is why it can be elevated in people with mets (the tumors damage the tissue as they grow, etc). However, going for an extra long run the day before you get your blood drawn and having sore muscles could also potentially create a slight increase over whatever your last values were. As I said before- ANY of the values on your bloodwork will fluctuate up and down some, rarely will they be the same twice (your BUN and creatinine indicators for your kidneys will rise dramatically if you happen to be a little dehydrated that day but it doesn't mean your kidney's are failing). As long as you remain inside the normal range it's not likely anything to be worry about. 

                  -eva

                  ecc26
                  Participant

                    I can't recall the normal range off the top of my head, but your values don't strike me as very high and if you're within the normal range I wouldn't worry about it. All of your bloodwork values will fluctuate a little from time to time- if you went back and tested again a week later it might have gone down again. As long as it stays within the range of "normal" I don't think there's any cause for concern. 

                    LDH is a bit crude as an indicator for metastases anyway. It is true that often people with mets (and generally a high number of them) will have elevated LDH, it is not always the case- I have close to 40 mets and my LDH has never been even remotely elevated. LDH itself is released into the blood most commonly with tissue damage or turnover, which is why it can be elevated in people with mets (the tumors damage the tissue as they grow, etc). However, going for an extra long run the day before you get your blood drawn and having sore muscles could also potentially create a slight increase over whatever your last values were. As I said before- ANY of the values on your bloodwork will fluctuate up and down some, rarely will they be the same twice (your BUN and creatinine indicators for your kidneys will rise dramatically if you happen to be a little dehydrated that day but it doesn't mean your kidney's are failing). As long as you remain inside the normal range it's not likely anything to be worry about. 

                    -eva

                    JerryfromFauq
                    Participant

                      I have heeaard of levels over 1500  that went down with melanoma treatment.  Your levels are well within  the normal.

                      Your healthcare provider may ask you to stop taking drugs that may affect the test. Drugs that can increase LDH measurements include alcohol, anesthetics, aspirin, clofibrate, fluorides, mithramycin, narcotics, and procainamide. Ascorbic acid (vitamin C) can lower levels of LDH.

                       

                      http://www.nlm.nih.gov/medlineplus/ency/article/003471.htm

                      Normal Results

                      A typical range is 105 – 333 IU/L (international units per liter).The examples above are common measurements for results of these tests. Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your doctor about the meaning of your specific test results.

                       

                      http://www.medicalhealthtests.com/askquestion/254/what-is-ldh-blood-test.html

                      What does elevated LDH levels mean?

                      The enzyme LDH or Lactic Acid Dehydrogenase is responsible for creating energy for the cells in the body. It is found in almost all body tissues and can be measured by a simple blood test.

                      Normal LDH levels are generally low and range between 140 IU/liter to 333 IU/ liter. Low LDH levels are usually no cause for concern. However, elevated LDH levels may indicate cell damage. This damage could be caused by a number of medical conditions. Some of the elevated LDH level causes include tissue damage due to trauma or disease, a recent heart attack, disease of the liver or the kidney or even the lungs, cancer, anemia, HIV, meningitis or encephalitis to name a few. If a blood test report is positive (a high LDH reading) more medical tests will be required to determine the actual cause of the cell damage. LDH tests are also used to monitor a patient's response to chemotherapy or to evaluate the rate of muscular degeneration or the progress of HIV.

                      JerryfromFauq
                      Participant

                        I have heeaard of levels over 1500  that went down with melanoma treatment.  Your levels are well within  the normal.

                        Your healthcare provider may ask you to stop taking drugs that may affect the test. Drugs that can increase LDH measurements include alcohol, anesthetics, aspirin, clofibrate, fluorides, mithramycin, narcotics, and procainamide. Ascorbic acid (vitamin C) can lower levels of LDH.

                         

                        http://www.nlm.nih.gov/medlineplus/ency/article/003471.htm

                        Normal Results

                        A typical range is 105 – 333 IU/L (international units per liter).The examples above are common measurements for results of these tests. Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your doctor about the meaning of your specific test results.

                         

                        http://www.medicalhealthtests.com/askquestion/254/what-is-ldh-blood-test.html

                        What does elevated LDH levels mean?

                        The enzyme LDH or Lactic Acid Dehydrogenase is responsible for creating energy for the cells in the body. It is found in almost all body tissues and can be measured by a simple blood test.

                        Normal LDH levels are generally low and range between 140 IU/liter to 333 IU/ liter. Low LDH levels are usually no cause for concern. However, elevated LDH levels may indicate cell damage. This damage could be caused by a number of medical conditions. Some of the elevated LDH level causes include tissue damage due to trauma or disease, a recent heart attack, disease of the liver or the kidney or even the lungs, cancer, anemia, HIV, meningitis or encephalitis to name a few. If a blood test report is positive (a high LDH reading) more medical tests will be required to determine the actual cause of the cell damage. LDH tests are also used to monitor a patient's response to chemotherapy or to evaluate the rate of muscular degeneration or the progress of HIV.

                          Gene_S
                          Participant

                            Your LDH is in the normal range and while it did go up in the last 6 months is still well within normal, as the others have stated.

                            My husbands was at 1200 when they found the cancer had spread to the liver and lungs.  He is in an Ipi Clinical Trial and after a few months his range dropped into the upper 300 range and the doctor thought this was great as he thought the Ipi was working.  He has remained in the 200 range for about 2 years now and he is now NED.

                            I would say don't worry and live life.

                            Judy (loving wife of Gene Stage IV and now NED)

                            HelenQLD
                            Participant
                              My mum was diagnosed stage iv nearly four weeks ago and her LDH level was 794. We are waiting for her latest test to come back to see the levels. Our oncologist said the levels can play a role in treatment as if the liver isn’t able to function at a certain level it can’t metabolise the medications.
                              HelenQLD
                              Participant
                                My mum was diagnosed stage iv nearly four weeks ago and her LDH level was 794. We are waiting for her latest test to come back to see the levels. Our oncologist said the levels can play a role in treatment as if the liver isn’t able to function at a certain level it can’t metabolise the medications.
                                HelenQLD
                                Participant
                                  My mum was diagnosed stage iv nearly four weeks ago and her LDH level was 794. We are waiting for her latest test to come back to see the levels. Our oncologist said the levels can play a role in treatment as if the liver isn’t able to function at a certain level it can’t metabolise the medications.
                                  Gene_S
                                  Participant

                                    Your LDH is in the normal range and while it did go up in the last 6 months is still well within normal, as the others have stated.

                                    My husbands was at 1200 when they found the cancer had spread to the liver and lungs.  He is in an Ipi Clinical Trial and after a few months his range dropped into the upper 300 range and the doctor thought this was great as he thought the Ipi was working.  He has remained in the 200 range for about 2 years now and he is now NED.

                                    I would say don't worry and live life.

                                    Judy (loving wife of Gene Stage IV and now NED)

                                    Gene_S
                                    Participant

                                      Your LDH is in the normal range and while it did go up in the last 6 months is still well within normal, as the others have stated.

                                      My husbands was at 1200 when they found the cancer had spread to the liver and lungs.  He is in an Ipi Clinical Trial and after a few months his range dropped into the upper 300 range and the doctor thought this was great as he thought the Ipi was working.  He has remained in the 200 range for about 2 years now and he is now NED.

                                      I would say don't worry and live life.

                                      Judy (loving wife of Gene Stage IV and now NED)

                                    JerryfromFauq
                                    Participant

                                      I have heeaard of levels over 1500  that went down with melanoma treatment.  Your levels are well within  the normal.

                                      Your healthcare provider may ask you to stop taking drugs that may affect the test. Drugs that can increase LDH measurements include alcohol, anesthetics, aspirin, clofibrate, fluorides, mithramycin, narcotics, and procainamide. Ascorbic acid (vitamin C) can lower levels of LDH.

                                       

                                      http://www.nlm.nih.gov/medlineplus/ency/article/003471.htm

                                      Normal Results

                                      A typical range is 105 – 333 IU/L (international units per liter).The examples above are common measurements for results of these tests. Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your doctor about the meaning of your specific test results.

                                       

                                      http://www.medicalhealthtests.com/askquestion/254/what-is-ldh-blood-test.html

                                      What does elevated LDH levels mean?

                                      The enzyme LDH or Lactic Acid Dehydrogenase is responsible for creating energy for the cells in the body. It is found in almost all body tissues and can be measured by a simple blood test.

                                      Normal LDH levels are generally low and range between 140 IU/liter to 333 IU/ liter. Low LDH levels are usually no cause for concern. However, elevated LDH levels may indicate cell damage. This damage could be caused by a number of medical conditions. Some of the elevated LDH level causes include tissue damage due to trauma or disease, a recent heart attack, disease of the liver or the kidney or even the lungs, cancer, anemia, HIV, meningitis or encephalitis to name a few. If a blood test report is positive (a high LDH reading) more medical tests will be required to determine the actual cause of the cell damage. LDH tests are also used to monitor a patient's response to chemotherapy or to evaluate the rate of muscular degeneration or the progress of HIV.

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