› Forums › General Melanoma Community › Mek/Taf combo – known to cause increased tumor load?
- This topic has 6 replies, 2 voices, and was last updated 8 years, 4 months ago by
Jahendry12.
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- January 14, 2017 at 4:27 am
Hello – I have read that targeted therapies can cause more tumors to appear ina short period of time. Does anyone have any personal experience with this?
thank you in advance.
- Replies
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- January 14, 2017 at 5:36 pm
Hi,
Are you already being treated with these drugs ? or considering them ?
I am BRAF wild type so not for me- think they are useful top reduce tumour load but good to swap to immunotherapy before resistance hits and cancer has mutated- which at that point can result in increased tumour load. The third bit here JAMES LARKIN discusses treatment sequencing https://am.asco.org/treating-advanced-melanoma-immunotherapies
and here might be worth a look http://www.onclive.com/printer?url=/peer-exchange-archive/advances-in-melanoma/sequencing-dual-braf-mek-inhibition-and-immunotherapy-
Best wishes- sorry no personal experience here…
Deb
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- January 14, 2017 at 5:36 pm
Hi,
Are you already being treated with these drugs ? or considering them ?
I am BRAF wild type so not for me- think they are useful top reduce tumour load but good to swap to immunotherapy before resistance hits and cancer has mutated- which at that point can result in increased tumour load. The third bit here JAMES LARKIN discusses treatment sequencing https://am.asco.org/treating-advanced-melanoma-immunotherapies
and here might be worth a look http://www.onclive.com/printer?url=/peer-exchange-archive/advances-in-melanoma/sequencing-dual-braf-mek-inhibition-and-immunotherapy-
Best wishes- sorry no personal experience here…
Deb
-
- January 14, 2017 at 5:36 pm
Hi,
Are you already being treated with these drugs ? or considering them ?
I am BRAF wild type so not for me- think they are useful top reduce tumour load but good to swap to immunotherapy before resistance hits and cancer has mutated- which at that point can result in increased tumour load. The third bit here JAMES LARKIN discusses treatment sequencing https://am.asco.org/treating-advanced-melanoma-immunotherapies
and here might be worth a look http://www.onclive.com/printer?url=/peer-exchange-archive/advances-in-melanoma/sequencing-dual-braf-mek-inhibition-and-immunotherapy-
Best wishes- sorry no personal experience here…
Deb
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- January 14, 2017 at 7:21 pm
Thank you for your response. Appreciate the info.
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- January 14, 2017 at 7:21 pm
Thank you for your response. Appreciate the info.
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- January 14, 2017 at 7:21 pm
Thank you for your response. Appreciate the info.
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