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Melanoma Molecular Disease Model

This topic has 4 replies, 2 voices, and was last updated 14 years, 3 months ago by MichaelFL.

Post

- May 31, 2011 at 6:19 am
- Quote
JerryfromFauq
Participant
LONG and Interesting Article which will have running on-line updates.

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0018257

Abstract:
While advanced melanoma remains one of the most challenging cancers, recent developments in our understanding of the molecular drivers of this disease have uncovered exciting opportunities to guide personalized therapeutic decisions. Genetic analyses of melanoma have uncovered several key molecular pathways that are involved in disease onset and progression, as well as prognosis. These advances now make it possible to create a “Molecular Disease Model” (MDM) for melanoma that classifies individual tumors into molecular subtypes (in contrast to traditional histological subtypes), with proposed treatment guidelines for each subtype including specific assays, drugs, and clinical trials. This paper describes such a Melanoma Molecular Disease Model reflecting the latest scientific, clinical, and technological advances.

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Replies

- - May 31, 2011 at 10:38 am
  - Quote
  James from Sydney
  Participant
  Jerry, thanks for posting this, it gives a good overview of Melanoma subtypes. Although there is much more to learn the understanding has progressed a long way in just a few years. It wasn't that long ago that all Melanoma patients were treated the same way.
  
  best wishes
  
  James
- - May 31, 2011 at 10:38 am
  - Quote
  James from Sydney
  Participant
  Jerry, thanks for posting this, it gives a good overview of Melanoma subtypes. Although there is much more to learn the understanding has progressed a long way in just a few years. It wasn't that long ago that all Melanoma patients were treated the same way.
  
  best wishes
  
  James
- - May 31, 2011 at 8:23 pm
  - Quote
  MichaelFL
  Participant
  Great reading Jerry! I wonder how many more subtypes and pathways they will find and learn to block before a cure is found? Tip of the iceberg-still…..
  
  Hope you are well and getting your gleevec.
  
  Michael
- - May 31, 2011 at 8:23 pm
  - Quote
  MichaelFL
  Participant
  Great reading Jerry! I wonder how many more subtypes and pathways they will find and learn to block before a cure is found? Tip of the iceberg-still…..
  
  Hope you are well and getting your gleevec.
  
  Michael

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