Metastatic Melanoma Patients may benefit from Pan Beta Blockers (with Immunoteraphy)

Unfortunately, the 2014 study failed to show any benefit when beta blockers were given to real live melanoma peeps. 

Where it was noted that: "Beta-blockers were prescribed after malignant melanoma diagnosis to 20.2% of 242 patients who died from malignant melanoma and 20.3% of 886 matched controls.  Contrary to some previous studies, beta-blocker usage after malignant melanoma diagnosis was not associated with reduced risk of death from melanoma in the UK population based study." 

However, the second study I note, with data published in December of 2017:  

"…researchers state that they saw improved OS in melanoma peeps who were simultaneously given immunotherapy, as was the case for more poor little melanoma affected mice.  They do point out that the effect was greater when melanoma peeps (or maybe they mean the mice…it's not clear) were also given high dose IL-2 with their anti-PD-1/beta blocker cocktail!"

Similar to the info Ed shared below.  Hope that makes it clearer.  I wish you my best. Celeste

Link doesn't work, please try it again.

Sorry, it worked on the third try, here is the actual study link.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652234/

Hi Sam did you read the actual study after the link to PubMed that you put up? If you have, I would bring your attention to two things, first the # of stage 4 patients in the data on table 1 was 1.3% for within 90 days and 3.6% for those outside of 90 days which are non very representive of advanced melanoma patients. Second things I would bring your attention to is this is a retrospective look back at medical records of the Danish population covering a very long period of time with no correlation to modern advancement in treating melanoma like check point inhibitors or targeted therapy and if you spend some time looking at table 1 it shows a higher death rate in stage 4 for those who were on ITT bolocker use and in the greater than 90 day prior to diagnosis group, more than 50% of patients had not staging or unknown staging. I am not sure that any medical oncologist would be caught using this data as evidence to give pan beta blockers. We all look for the golden goose when faced with this shitty disease, but remember and have some faith in the process of research. In the field of melanoma oncology many new and promising trials of new combinations are being run. I wouldn't jump on every article that gets written as the next great thing and start using what they are researching, since so many like Pembro+Ido don't always work out. Best Wishes!!!Ed