MK-1454 Clinical Trial

Here are a couple of articles about Mk-1454, which is another injectable and in this case it is trying to target the ‘Sting” pathway. At the 12:33 min mark of the following video that features Dr. Omid Hamid he gets into injectables and he talks a little about the sting pathway. T-vec + ipi has been studied over the last few years as well as t-vec plus pembro and I thing nivo, TLR-9 agoinst are being investigated and there are a few more trials of different agent mainly for melanoma resistant patients to immunotherapy. To the best of my knowledge other than T-vec none have been approved yet but many of them show promise!!! I will give you a couple of article on MK-1454 that I came across and from what I have found it seems only a small # of patients have tried this drug and I am not sure if any melanoma patients have tried. T-vec on the other hand is a little future down the road when it comes to actual melanoma patients and actual results in melanoma patients. Best Wishes!!!Ed https://investors.merck.com/news/press-release-details/2018/First-Presentation-of-Early-Data-for-Mercks-Investigational-STING-Agonist-MK-1454-in-Patients-with-Advanced-Solid-Tumors-or-Lymphomas-at-ESMO-2018-Congress/default.aspx https://dailynews.ascopubs.org/do/10.1200/ADN.19.190427/full/

Ed has given you good information – as ever. Here are some additional articles on intralesional therapy: https://chaoticallypreciselifeloveandmelanoma.blogspot.com/search?q=intralesional&max-results=20&by-date=true

As far as picking the trial I would participate in if I were in your mom’s shoes????

I would have the doc give me a specific list of the trials for which she is considered eligible and have him give me a play by play of the pros and cons of each. Additional important information to my mind is speed of entry. Melanoma makes the most of time it has untreated and some trials required certain lengths of “wash out” periods or just ‘x’ amount of time to get enrolled.

Yours, celeste

I agree with Celeste about requesting specific pros and cons from your oncologist regarding each trial your mom is eligible for, as well as how quickly she can start. I would not be concerned about having weekly liver biopsies since it is not a very invasive procedure. I had 4 liver tumors, the largest also being 7 cm and my melanoma was diagnosed following a liver biopsy. I had minimal pain afterward and was home the same day after 4-5 hrs in the hospital only as an inpatient. Compared to the immunotherapy and targeted treatment side-effects, the actual liver biopsy is absolutely nothing to be worried about. Hopefully, the liver tumor shrinks enough so that it becomes surgically resectable. Also, once the tumor burden is reduced, maybe another type of therapy is more effective.
Best of luck,