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Nercosis
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Nercosis

› Forums › General Melanoma Community › Nercosis

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    • January 30, 2021 at 7:53 am
    Lilara
    Participant
      my mom wanted to get lag3 and pdl1 clinical trial treatment but they wanted to get the biopsy to do molecular testing .

      today we got this result from her pathology report :Given the extensive necrosis, this specimen would not be appropriate for molecular testing. The tumor that they did the biopsy shows extensive deal tissue . She was on keytruda but her tumor progress never shrinked. But now it shows dead melanoma cell. Does this mean keytruda is doing something ?

      please let me know.Thanks

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        • January 30, 2021 at 9:34 pm
        Mark_DC
        Participant
          Hi Lilara,

          I think you need an expert to respond, but no one responded so I will try. Necrosis is obviously (I think) a good thing, so whatever medicine she was taking has had an effect. I cant remember all the details of your mum’s case but I think you were worried treatment was not working and you were being denied ipi/nivo or something else.

          With my tumour the oncologist often hoped it was necrotic but every time we did a biopsy it came back as melanoma.

          My only question is, although this is a good sign, maybe they have to re-sample to find a part of the tumour that is not necrotic. So although necrosis is good news, I am not sure that it means the whole thing is necrotic. And are there other tumours? So they may have to re-sample. (But these are all guesses, sorry. At least you have some good news!!!!)

            • February 1, 2021 at 10:05 pm
            Lilara
            Participant
              Thanks Mark for your response . My mom was on keytruda but the tumors were not shrinking so the dr is looking at her tumor to see if she is eligible for pd1 and lag3 , since she was denied ipi/nivo

              but now at her biopsy they have found extensive necrosis . So we will see the dr on Thursday. So I hope the cancer cells are dying . But I don’t know why her tumor is growing :-(. Thanks for your response . I am praying all the time so that she can have something that works for her .

              Lila

              • February 1, 2021 at 11:46 pm
              Mark_DC
              Participant
                Hi Lila,

                How many tumours does your mum have? If she has more then maybe they will do the biopsy on another one, and then they can do the pd1/lag3. (Why denied ipi/nivo?).

                But if she only has one and has necrosis then you might have good news!!! It can grow because the tumour becomes inflamed (I think). Keytruda worked for me on a small tumour but only after that thing grew a little which freaked me out, but actually this was good news it then shrank. And I think on my other one, with TVEC it grew a little before slowly shrinking.

                Dont be overoptimistic – it may just be they take a new sample (I am not an expert!!!!). But maybe you have good news. I dont see how necrosis can be bad news!

                Hope things will be clearer thursday

                Mark

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