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New PD-L1 inhibitors
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New PD-L1 inhibitors

› Forums › General Melanoma Community › New PD-L1 inhibitors

  • Post
    • May 19, 2016 at 5:32 pm
    JohnA
    Participant

      Hey folks, 

       

      These are being tested in other cancers, but I wonder if they will come to have relevance for the melanoma community?

      I thought some of you might be interested-

      John

       

      In the 61-patient study, about 30 percent of those with Merkel skin cell carcinoma treated with Merck's avelumab saw their tumors shrink or disappear.

      Avelumab, which German Merck is developing with Pfizer Inc , belongs to a class of drugs called PD-L1 inhibitors that block a mechanism tumors use to hide from the immune system, allowing it to recognize and attack the cancer. They are closely related to the PD-1 drugs already on the market from Bristol-Myers Squibb (Opdivo) and Merck & Co (Keytruda) seen as major advances against melanoma, lung cancer and other malignancies.

      Roche's Tecentriq earlier on Wednesday became the first approved PD-L1 drug, gaining U.S. approval to treat advanced bladder cancer.

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