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Hi Mike, first off welcome to the forum! I know in Canada, where the combination of Ipi and Nivo was first made available 2 years ago, as part of the clinical trial checkmate 67. If I were you I would contact Bristol Myer Squibb directly and ask if you would qualify for their expanded access program. Best wishes!!! Ed

Hi Mike, first off welcome to the forum! I know in Canada, where the combination of Ipi and Nivo was first made available 2 years ago, as part of the clinical trial checkmate 67. If I were you I would contact Bristol Myer Squibb directly and ask if you would qualify for their expanded access program. Best wishes!!! Ed

Hi Mike, first off welcome to the forum! I know in Canada, where the combination of Ipi and Nivo was first made available 2 years ago, as part of the clinical trial checkmate 67. If I were you I would contact Bristol Myer Squibb directly and ask if you would qualify for their expanded access program. Best wishes!!! Ed

Mike, I live in the UK and started pembro in January at the Royal Marsden Hospital in London. It's one of.the top cancer hospitals in Europe and are involved in many trials. Many of the patients I meet and talk to are on trials. Try contacting the Marsden to check if they have any open trials for you. Very best wishes. Mel J

Mike, I live in the UK and started pembro in January at the Royal Marsden Hospital in London. It's one of.the top cancer hospitals in Europe and are involved in many trials. Many of the patients I meet and talk to are on trials. Try contacting the Marsden to check if they have any open trials for you. Very best wishes. Mel J

Mike, I live in the UK and started pembro in January at the Royal Marsden Hospital in London. It's one of.the top cancer hospitals in Europe and are involved in many trials. Many of the patients I meet and talk to are on trials. Try contacting the Marsden to check if they have any open trials for you. Very best wishes. Mel J

Hi Mike,

I wanted to chime in that when I was diagnosed with Stage IV, I went through the (formerly standard) ipi -> Keytruda infusions.  I benefitted from it greatly and it's difficult to determine whether subsequent treatments rather than combo treatments are preferable.  I believe the combo is only being tested versus Nivo alone and I think that means that the combo trials require you to have not done ipi.  

To that end, it may be worth considering the ipi (and if failed) keytruda route.  I'm not sure if there's a "sequencing" trial or not, but when I discussed it with my doc, she suggested that at least a few people think sequencing them may be preferable to keytruda alone.  

Either way, best of luck.  It looks like you're trying to make the most educated and best decision you can.  

-Justin

Hi Mike,

I wanted to chime in that when I was diagnosed with Stage IV, I went through the (formerly standard) ipi -> Keytruda infusions.  I benefitted from it greatly and it's difficult to determine whether subsequent treatments rather than combo treatments are preferable.  I believe the combo is only being tested versus Nivo alone and I think that means that the combo trials require you to have not done ipi.  

To that end, it may be worth considering the ipi (and if failed) keytruda route.  I'm not sure if there's a "sequencing" trial or not, but when I discussed it with my doc, she suggested that at least a few people think sequencing them may be preferable to keytruda alone.  

Either way, best of luck.  It looks like you're trying to make the most educated and best decision you can.  

-Justin

Hi Mike,

I wanted to chime in that when I was diagnosed with Stage IV, I went through the (formerly standard) ipi -> Keytruda infusions.  I benefitted from it greatly and it's difficult to determine whether subsequent treatments rather than combo treatments are preferable.  I believe the combo is only being tested versus Nivo alone and I think that means that the combo trials require you to have not done ipi.  

To that end, it may be worth considering the ipi (and if failed) keytruda route.  I'm not sure if there's a "sequencing" trial or not, but when I discussed it with my doc, she suggested that at least a few people think sequencing them may be preferable to keytruda alone.  

Either way, best of luck.  It looks like you're trying to make the most educated and best decision you can.  

-Justin

Hi Mike,

I agree you should fight for the combo if it's at all possible. My onc originally wanted to start me on a mono-therapy (nivo only), but after second and third opinions I was convinced the combo was the way to go, rather than mono or sequential. But it's a tough regiment and can really do a number on your system, so depending on how aggressive your melanoma is some might recommend starting off with nivo first and watch closely for disease progression.

Not sure your options in Europe and/or on your insurance…but you're asking the right questions!!

Best of luck, 

Hi Mike,

I agree you should fight for the combo if it's at all possible. My onc originally wanted to start me on a mono-therapy (nivo only), but after second and third opinions I was convinced the combo was the way to go, rather than mono or sequential. But it's a tough regiment and can really do a number on your system, so depending on how aggressive your melanoma is some might recommend starting off with nivo first and watch closely for disease progression.

Not sure your options in Europe and/or on your insurance…but you're asking the right questions!!

Best of luck, 

Hi Mike,

I agree you should fight for the combo if it's at all possible. My onc originally wanted to start me on a mono-therapy (nivo only), but after second and third opinions I was convinced the combo was the way to go, rather than mono or sequential. But it's a tough regiment and can really do a number on your system, so depending on how aggressive your melanoma is some might recommend starting off with nivo first and watch closely for disease progression.

Not sure your options in Europe and/or on your insurance…but you're asking the right questions!!

Best of luck,