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Newly diagnosed and pregnant

Forums Cutaneous Melanoma Community Newly diagnosed and pregnant

  • Post
    sunshinlilyrose
    Participant

      Hi all,  so I had a weird growth  on my lower hip for a while and finally had it biopsied. My primary called me yesterday to tell me it is melanoma and told me to see a Dermotologist with a speciality in skin cancers. She faxed me over the pathology report but I don't really understand it.  I would appreciate any help deciphering it.  I also found out I am 7 weeks pregnant and am wondering if this is going to hinder any additional tests I may need…..smh….very stressed.  Ok, this is what my report says

      malignant melanoma, superficial spreading type, invasive to level 2 and a measured thickness of 0.4mm, arising in the background of a compound dysplastic nevus with severe atypia, close to lateral and deep margins. ( please see consultation report from dr Martin c. Mihm of Harvard )

      ok so above is exactly what mine said, including the parentheses, which btw I did not get a copy of that report. 

      Thanks all!!!

    Viewing 11 reply threads
    • Replies
        Germer
        Participant

          I was diagnosed when I was 20 weeks pregnant with my daughter so I understand how stressed you are feeling. The good news is that you have a very thin melanoma which carries an excellent prognosis!

           If I were you I would find a dermotologist who specializes in melanoma. I am no sure what area you live in, but I think Boston since you had a consultation report from Harvard. Dana Farber in Boston is great and maybe others can chime in with more melanoma center options.  You will have another surgery to get wider margins around the area of the melanoma. This was out patient with local anastesia for me. Because your melanoma is so thin I would be surprised if they wanted to remove any lymph nodes. In general, if you are stage IA, which it looks like from your report, being pregnant with not hinder any additional tests. Normally, you will need to return to your dermotologist every three months to get checked out, which is not an issue while pregnant.

          I wish you all the best and good luck! 

          Germer
          Participant

            I was diagnosed when I was 20 weeks pregnant with my daughter so I understand how stressed you are feeling. The good news is that you have a very thin melanoma which carries an excellent prognosis!

             If I were you I would find a dermotologist who specializes in melanoma. I am no sure what area you live in, but I think Boston since you had a consultation report from Harvard. Dana Farber in Boston is great and maybe others can chime in with more melanoma center options.  You will have another surgery to get wider margins around the area of the melanoma. This was out patient with local anastesia for me. Because your melanoma is so thin I would be surprised if they wanted to remove any lymph nodes. In general, if you are stage IA, which it looks like from your report, being pregnant with not hinder any additional tests. Normally, you will need to return to your dermotologist every three months to get checked out, which is not an issue while pregnant.

            I wish you all the best and good luck! 

            Germer
            Participant

              I was diagnosed when I was 20 weeks pregnant with my daughter so I understand how stressed you are feeling. The good news is that you have a very thin melanoma which carries an excellent prognosis!

               If I were you I would find a dermotologist who specializes in melanoma. I am no sure what area you live in, but I think Boston since you had a consultation report from Harvard. Dana Farber in Boston is great and maybe others can chime in with more melanoma center options.  You will have another surgery to get wider margins around the area of the melanoma. This was out patient with local anastesia for me. Because your melanoma is so thin I would be surprised if they wanted to remove any lymph nodes. In general, if you are stage IA, which it looks like from your report, being pregnant with not hinder any additional tests. Normally, you will need to return to your dermotologist every three months to get checked out, which is not an issue while pregnant.

              I wish you all the best and good luck! 

                sunshinlilyrose
                Participant

                  Thanks so much for the response….I didn't sleep very well last night. How can you tell it is thin? I actually live in nj but thanks for the info. My primary recommended someone to me I'm just waiting until they open. Let me tell you after reading online I was pretty sure this was a death sentence so I was very happy to come across this sight. Does anyone know if there are specific tests I should ask doctor to perform. Thanks again for all the info.

                  sunshinlilyrose
                  Participant

                    Thanks so much for the response….I didn't sleep very well last night. How can you tell it is thin? I actually live in nj but thanks for the info. My primary recommended someone to me I'm just waiting until they open. Let me tell you after reading online I was pretty sure this was a death sentence so I was very happy to come across this sight. Does anyone know if there are specific tests I should ask doctor to perform. Thanks again for all the info.

                    sunshinlilyrose
                    Participant

                      Thanks so much for the response….I didn't sleep very well last night. How can you tell it is thin? I actually live in nj but thanks for the info. My primary recommended someone to me I'm just waiting until they open. Let me tell you after reading online I was pretty sure this was a death sentence so I was very happy to come across this sight. Does anyone know if there are specific tests I should ask doctor to perform. Thanks again for all the info.

                      Germer
                      Participant

                        This is not a death sentence! It states in the pathology report that the thickness of the melanoma is .4mm. Anything under 1 mm with a low miotic rate that isn't ulcerated is considered stage 1a. The basic thinking is the thinner the melanoma the better the outcome. 

                        I went to the Sloan Kettering Melanoma Clinic which is in Long Island, which might not be too far from you depending where in Jersey you are. They were really great. I would definitely ask about a Sentinal Node Biopsy, but I would be super surprised with how thin your melanoma is if it would be done. Always better to ask and see what they say. 

                        Germer
                        Participant

                          This is not a death sentence! It states in the pathology report that the thickness of the melanoma is .4mm. Anything under 1 mm with a low miotic rate that isn't ulcerated is considered stage 1a. The basic thinking is the thinner the melanoma the better the outcome. 

                          I went to the Sloan Kettering Melanoma Clinic which is in Long Island, which might not be too far from you depending where in Jersey you are. They were really great. I would definitely ask about a Sentinal Node Biopsy, but I would be super surprised with how thin your melanoma is if it would be done. Always better to ask and see what they say. 

                          Germer
                          Participant

                            This is not a death sentence! It states in the pathology report that the thickness of the melanoma is .4mm. Anything under 1 mm with a low miotic rate that isn't ulcerated is considered stage 1a. The basic thinking is the thinner the melanoma the better the outcome. 

                            I went to the Sloan Kettering Melanoma Clinic which is in Long Island, which might not be too far from you depending where in Jersey you are. They were really great. I would definitely ask about a Sentinal Node Biopsy, but I would be super surprised with how thin your melanoma is if it would be done. Always better to ask and see what they say. 

                          BrianP
                          Participant

                            Lilyrose,

                            Although all melanoma is serious, generally melanoma's less than 1.0 thick is considered low risk.  I'm going to restrain from giving any advice because I suspect Janner will chime in soon as she is outstanding for giving advice to folks in your situation.  I might suggest you let us know your general location (North, South, Central NJ).  I'm sure we have people on the forum that can give you suggestions for a dermatologist specializing in melanoma in your area.  Hang in there.  Like the first poster said, your prognosis is very good at this point.  You did a great job in catching this early.

                            Brian

                            BrianP
                            Participant

                              Lilyrose,

                              Although all melanoma is serious, generally melanoma's less than 1.0 thick is considered low risk.  I'm going to restrain from giving any advice because I suspect Janner will chime in soon as she is outstanding for giving advice to folks in your situation.  I might suggest you let us know your general location (North, South, Central NJ).  I'm sure we have people on the forum that can give you suggestions for a dermatologist specializing in melanoma in your area.  Hang in there.  Like the first poster said, your prognosis is very good at this point.  You did a great job in catching this early.

                              Brian

                              BrianP
                              Participant

                                Lilyrose,

                                Although all melanoma is serious, generally melanoma's less than 1.0 thick is considered low risk.  I'm going to restrain from giving any advice because I suspect Janner will chime in soon as she is outstanding for giving advice to folks in your situation.  I might suggest you let us know your general location (North, South, Central NJ).  I'm sure we have people on the forum that can give you suggestions for a dermatologist specializing in melanoma in your area.  Hang in there.  Like the first poster said, your prognosis is very good at this point.  You did a great job in catching this early.

                                Brian

                                  JC
                                  Participant

                                    Also I would have no doubts about the accuracy of your pathology – Mihm is world renowned expert.  So, I'd be confident in the staging from the pathology.

                                     

                                     

                                     

                                    JC
                                    Participant

                                      Also I would have no doubts about the accuracy of your pathology – Mihm is world renowned expert.  So, I'd be confident in the staging from the pathology.

                                       

                                       

                                       

                                      JC
                                      Participant

                                        Also I would have no doubts about the accuracy of your pathology – Mihm is world renowned expert.  So, I'd be confident in the staging from the pathology.

                                         

                                         

                                         

                                        sunshinlilyrose
                                        Participant

                                          I can't thank you all enough for taking time to give me info. I currently live in howell nj which is Monmouth county. I was thinking it would be worth the ride to go up to Sloan Kettering in basking ridge, I called and they gave me a consult date of 3/18/14.

                                          sunshinlilyrose
                                          Participant

                                            I can't thank you all enough for taking time to give me info. I currently live in howell nj which is Monmouth county. I was thinking it would be worth the ride to go up to Sloan Kettering in basking ridge, I called and they gave me a consult date of 3/18/14.

                                            sunshinlilyrose
                                            Participant

                                              I can't thank you all enough for taking time to give me info. I currently live in howell nj which is Monmouth county. I was thinking it would be worth the ride to go up to Sloan Kettering in basking ridge, I called and they gave me a consult date of 3/18/14.

                                              Linny
                                              Participant

                                                I used to live in Lakewood! Small world.

                                                Since you live in central Jersey you have a number of other options open to you if things don't pan out for you in Basking Ridge. When you have something like melanoma you want to make sure you see a physician who looks at these things on a daily basis and specializes in it. I'm not 100% sure that Sloan's facility in Basking Ridge has one of their melanoma specialists practicing there.

                                                Abramson Cancer Center has a melanoma clinic and they are in Phillie. Traffic-wise it's a LOT less stressful to go to Phillie than NYC. And since you're probably not far from Interstate 195, it's a piece of cake to get to Phillie.

                                                There's also the Cancer Institute of NJ in New Brunswick that has a melanoma clinic. I think they're part of Robert Wood Johnson. Don't know much about them, though.

                                                St. Luke's in Bethlehem, PA is also doable for you.

                                                 

                                                 

                                                Linny
                                                Participant

                                                  I used to live in Lakewood! Small world.

                                                  Since you live in central Jersey you have a number of other options open to you if things don't pan out for you in Basking Ridge. When you have something like melanoma you want to make sure you see a physician who looks at these things on a daily basis and specializes in it. I'm not 100% sure that Sloan's facility in Basking Ridge has one of their melanoma specialists practicing there.

                                                  Abramson Cancer Center has a melanoma clinic and they are in Phillie. Traffic-wise it's a LOT less stressful to go to Phillie than NYC. And since you're probably not far from Interstate 195, it's a piece of cake to get to Phillie.

                                                  There's also the Cancer Institute of NJ in New Brunswick that has a melanoma clinic. I think they're part of Robert Wood Johnson. Don't know much about them, though.

                                                  St. Luke's in Bethlehem, PA is also doable for you.

                                                   

                                                   

                                                  Linny
                                                  Participant

                                                    I used to live in Lakewood! Small world.

                                                    Since you live in central Jersey you have a number of other options open to you if things don't pan out for you in Basking Ridge. When you have something like melanoma you want to make sure you see a physician who looks at these things on a daily basis and specializes in it. I'm not 100% sure that Sloan's facility in Basking Ridge has one of their melanoma specialists practicing there.

                                                    Abramson Cancer Center has a melanoma clinic and they are in Phillie. Traffic-wise it's a LOT less stressful to go to Phillie than NYC. And since you're probably not far from Interstate 195, it's a piece of cake to get to Phillie.

                                                    There's also the Cancer Institute of NJ in New Brunswick that has a melanoma clinic. I think they're part of Robert Wood Johnson. Don't know much about them, though.

                                                    St. Luke's in Bethlehem, PA is also doable for you.

                                                     

                                                     

                                                    JC
                                                    Participant

                                                      I doubt you would need to see an oncologist at Stage IA, just someone to do the wide excision

                                                      JC
                                                      Participant

                                                        I doubt you would need to see an oncologist at Stage IA, just someone to do the wide excision

                                                        JC
                                                        Participant

                                                          I doubt you would need to see an oncologist at Stage IA, just someone to do the wide excision

                                                          Lil0909
                                                          Participant

                                                            Agreed about Mihm – from what my onc told me, he is one of 3 melanoma pathologist in the country.  I'm actually having him do a 2nd opinion on my SNB path right now. 

                                                            Lil0909
                                                            Participant

                                                              Agreed about Mihm – from what my onc told me, he is one of 3 melanoma pathologist in the country.  I'm actually having him do a 2nd opinion on my SNB path right now. 

                                                              Lil0909
                                                              Participant

                                                                Agreed about Mihm – from what my onc told me, he is one of 3 melanoma pathologist in the country.  I'm actually having him do a 2nd opinion on my SNB path right now. 

                                                                POW
                                                                Participant

                                                                  Brian is right, Janner is our melanoma guru especially for early stage melanoma like yours is. Hopefully, she will chime in soon.

                                                                  In the meanwhile, let me put things in context. The three most important details in a path report are: 1) Breslow depth (how deep the melanoma is growing into your skin), 2) mitotic index (how fast the cells are dividing), and 3) ulceration (whether the lesion has ruptured). Your Breslow depth of 0.4 mm is thin. Most doctors don't worry about it until a lesion is at least 0.76 or 1.0 mm. Some people are diagnosed with Breslow >4.0 mm and some even > 8.0 mm. So yours is thin, which is good. Your path report does not mention mitotic index so I assume that they didn't see any actively dividing cells under the microscope. That is also good. And your lesion is not ulcerated. Again, good.

                                                                  It sounds like you had what you might call a "funny-looking mole" (non-cancerous dysplastic nevus) that was just starting to turn cancerous. You acted quickly and caught it early. You will probably now have a "wide local excision" (WLE) to make absolutely certain that they got it all and then regular follow-ups with a melanoma dermatologist for quite a while. You and your baby will both be fine. 

                                                                  POW
                                                                  Participant

                                                                    Brian is right, Janner is our melanoma guru especially for early stage melanoma like yours is. Hopefully, she will chime in soon.

                                                                    In the meanwhile, let me put things in context. The three most important details in a path report are: 1) Breslow depth (how deep the melanoma is growing into your skin), 2) mitotic index (how fast the cells are dividing), and 3) ulceration (whether the lesion has ruptured). Your Breslow depth of 0.4 mm is thin. Most doctors don't worry about it until a lesion is at least 0.76 or 1.0 mm. Some people are diagnosed with Breslow >4.0 mm and some even > 8.0 mm. So yours is thin, which is good. Your path report does not mention mitotic index so I assume that they didn't see any actively dividing cells under the microscope. That is also good. And your lesion is not ulcerated. Again, good.

                                                                    It sounds like you had what you might call a "funny-looking mole" (non-cancerous dysplastic nevus) that was just starting to turn cancerous. You acted quickly and caught it early. You will probably now have a "wide local excision" (WLE) to make absolutely certain that they got it all and then regular follow-ups with a melanoma dermatologist for quite a while. You and your baby will both be fine. 

                                                                    POW
                                                                    Participant

                                                                      Brian is right, Janner is our melanoma guru especially for early stage melanoma like yours is. Hopefully, she will chime in soon.

                                                                      In the meanwhile, let me put things in context. The three most important details in a path report are: 1) Breslow depth (how deep the melanoma is growing into your skin), 2) mitotic index (how fast the cells are dividing), and 3) ulceration (whether the lesion has ruptured). Your Breslow depth of 0.4 mm is thin. Most doctors don't worry about it until a lesion is at least 0.76 or 1.0 mm. Some people are diagnosed with Breslow >4.0 mm and some even > 8.0 mm. So yours is thin, which is good. Your path report does not mention mitotic index so I assume that they didn't see any actively dividing cells under the microscope. That is also good. And your lesion is not ulcerated. Again, good.

                                                                      It sounds like you had what you might call a "funny-looking mole" (non-cancerous dysplastic nevus) that was just starting to turn cancerous. You acted quickly and caught it early. You will probably now have a "wide local excision" (WLE) to make absolutely certain that they got it all and then regular follow-ups with a melanoma dermatologist for quite a while. You and your baby will both be fine. 

                                                                      JC
                                                                      Participant

                                                                        " was just starting to turn cancerous"

                                                                        I don't know that I agree with that, as this was invasive, not in situ.  Melanoma with any depth, such as 0.4mm, means it was invasive and penetrated the epidermis into the dermis.  Although thin, which is good, still invasive.  Severly atypical or in situ I might agree is "just starting to turn cancerous"

                                                                         

                                                                        The other thing you might ask about if you don't see mentioned in pathology is regression.

                                                                        JC
                                                                        Participant

                                                                          " was just starting to turn cancerous"

                                                                          I don't know that I agree with that, as this was invasive, not in situ.  Melanoma with any depth, such as 0.4mm, means it was invasive and penetrated the epidermis into the dermis.  Although thin, which is good, still invasive.  Severly atypical or in situ I might agree is "just starting to turn cancerous"

                                                                           

                                                                          The other thing you might ask about if you don't see mentioned in pathology is regression.

                                                                          JC
                                                                          Participant

                                                                            " was just starting to turn cancerous"

                                                                            I don't know that I agree with that, as this was invasive, not in situ.  Melanoma with any depth, such as 0.4mm, means it was invasive and penetrated the epidermis into the dermis.  Although thin, which is good, still invasive.  Severly atypical or in situ I might agree is "just starting to turn cancerous"

                                                                             

                                                                            The other thing you might ask about if you don't see mentioned in pathology is regression.

                                                                            Brent Morris
                                                                            Participant

                                                                              To be accurate Breslow refers to the thickness of the tumor and the depth (or penetration into the skin) is the Clark level. In your instance both are at the lower (good) end of the scales. In spite of the early character of this melanoma I would not take it lightly. The descripton of the margins needs to be discussed. Sometimes a reexcision is done to ensure adequate margins.Thin melanomas in young individuals can sometimes be more aggressive. All the more reason to seek out a melanoma specialist. Martin Mihm is one of the best dermatopathologists in the world. You have started at a good place.

                                                                              JC
                                                                              Participant

                                                                                “Thin melanomas in young individuals can sometimes be more aggressive.”

                                                                                More so, for some reason, than others?  Why would that be?

                                                                                Brent Morris
                                                                                Participant

                                                                                  There has been debate in the literature about whether to do an SNB in thin melanomas (less than 0.76-1mm). However, some data have shown a positive rate as high as 5% in young patients with thin lesions. Attempts have been made to find distinquishing characteristics. The presence of a mitotic rate greater than 0, a vertical growth phase, clark level 4, male sex, and age less than forty years may all be factors. Below are two relevant references which support this counter intuitive phenomena.

                                                                                  Incidence of Sentinel Node Metastasis in Patients With Thin Primary Melanoma (#1 mm) With Vertical Growth Phase

                                                                                  Abstract

                                                                                  Background: Patients with thin primary melanomas (#1 mm) generally have an excellent prognosis. However, the presence of a vertical growth phase (VGP) adversely impacts the survival rate. We report on the rate of occurrence of nodal metastasis in patients with thin primary melanomas with a VGP who are offered sentinel lymph node (SLN) biopsy.

                                                                                  Methods: Among 235 patients with clinically localized cutaneous melanomas who underwent successful SLN biopsy, 71 had lesions 1 mm or smaller with a VGP. The SLN was localized by using blue dye and a radiotracer. If negative for tumor by using hematoxylin and eosin staining, the SLN was further examined by immunohistochemistry.

                                                                                  Results: The rate of occurrence of SLN metastasis was 15.2% in patients with melanomas deeper than 1 mm and 5.6% in patients with thin melanomas. Three patients with thin melanomas and a positive SLN had low-risk lesions, based on a highly accurate six-variable multivariate logistic regression model for predicting 8-year survival in stage I/II melanomas. The fourth patient had a low- to intermediate-risk lesion based on this model. At the time of the lymphadenectomy, one patient had two additional nodes with metastasis.

                                                                                  Conclusions: VGP in a melanoma 1 mm or smaller seems to be a risk factor for nodal metastasis. The risk of nodal disease may not be accurately predicted by the use of a multivariate logistic regression model that incorporates thickness, mitotic rate, regression, tumor-infiltrating lymphocytes, sex, and anatomical site. Patients with thin lesions having VGP should be evaluated for SLN biopsy and trials of adjuvant therapy when stage III disease is found.

                                                                                  Presented at the 52nd Annual Meeting of the Society of Surgical Oncology, Orlando, Florida, March 4–7, 1999.
                                                                                   
                                                                                  ___________________________________________________________________________________
                                                                                   
                                                                                  Ann Surg Oncol. 2014 Feb 15. [Epub ahead of print]

                                                                                  Age as a Predictor of Sentinel Node Metastasis among Patients with Localized Melanoma: An Inverse Correlation of Melanoma Mortality and Incidence of Sentinel Node Metastasis Among Young and Old Patients.

                                                                                  Abstract

                                                                                  PURPOSE:

                                                                                  We have previously reported that older patients with clinical stage I and II primary cutaneous. Melanoma had lower survival rates compared to younger patients. We postulated that the incidence of nodal metastasis would therefore be higher among older melanoma patients.

                                                                                  METHODS:

                                                                                  The expanded American Joint Committee on Cancer melanoma staging database contains a cohort of 7,756 melanoma patients who presented without clinical evidence of regional lymph node or distant metastasis and who underwent a sentinel node biopsy procedure as a component of their staging assessment.

                                                                                  RESULTS:

                                                                                  Although older patients had primary melanoma features associated with more aggressive biology, we paradoxically observed a significant decrease in the incidence of sentinel node metastasis as patient age increased. Overall, the highest incidence of sentinel node metastasis was 25.8 % in patients under 20 years of age, compared to 15.5 % in patients 80 years and older (p < 0.001). In contrast, 5-year mortality rates for clinical stage II patients ranged from a low of 20 % for those 20-40 years of age up to 38 % for those over 70 years of age. Patient age was an independent predictor of sentinel node metastasis in a multifactorial analysis (p < 0.001).

                                                                                  CONCLUSIONS:

                                                                                  Patients with clinical stage I and II melanoma under 20 years of age had a higher incidence of sentinel lymph node metastasis but, paradoxically, a more favorable survival outcome compared to all other age groups. In contrast, patients >70 years had the most aggressive primary melanoma features and a higher mortality rate compared to all other age groups but a lower incidence of sentinel lymph node metastasis.

                                                                                   

                                                                                  JC
                                                                                  Participant

                                                                                    where do you see " age less than forty years"?

                                                                                    Brent Morris
                                                                                    Participant

                                                                                      I think you will find the statistics in this reference.

                                                                                       

                                                                                      Arch Surg. Author manuscript; available in PMC 2011 February 1.
                                                                                      Published in final edited form as:

                                                                                      PMCID: PMC2880665
                                                                                      NIHMSID: NIHMS192811

                                                                                      Predictors of Occult Nodal Metastasis in Patients with Thin Melanoma

                                                                                      Abstract

                                                                                      Background and Hypothesis

                                                                                      Although thin primary lesions are largely responsible for the rapid increase in melanoma incidence, making identification of appropriate candidates for nodal staging in this group critically important. We hypothesized that common clinical parameters may accurately estimate the risk of nodal metastasis after wide excision and determine the need for sentinel node (SN) biopsy.

                                                                                      Design and Setting

                                                                                      Review of prospectively acquired data in the large melanoma database at a tertiary referral center

                                                                                      Patients and Methods

                                                                                      We identified patients seen within 6 months of diagnosis of thin (<1 mm) melanoma and treated by wide excision alone. We examined the rate of regional nodal recurrence and the impact of clinical/demographic variables by univariate and multivariate analyses.

                                                                                      Results

                                                                                      The overall nodal recurrence rate was 2.9%; median time to recurrence was 38.3 months. Univariate analysis of 1732 patients identified male sex (p<0.001), increased Breslow thickness (p<0.001), and increased Clark level (p<0.001) as significant for nodal recurrence. Multivariate analysis identified male sex (p=0.0005, HR 3.5), younger age (p=0.0019, HR 0.45), and increased Breslow thickness (categorical, p<0.001, HR 2.47) as significant. Clark was no longer significant (p=0.6). Breslow thickness, age and sex were used to develop a scoring system and nomogram for the risk of nodal involvement: predictions ranged from 0.1% in the lowest risk group to 17.4% in the highest risk group.

                                                                                      Conclusion

                                                                                      Many patients with thin melanoma will have nodal recurrence after wide excision alone. Three simple clinical parameters may be used to estimate recurrence risk and select patients for SN biopsy.

                                                                                       

                                                                                      It includes this figure:

                                                                                       

                                                                                      An external file that holds a picture, illustration, etc.
Object name is nihms192811f1.jpg

                                                                                       

                                                                                      Brent Morris
                                                                                      Participant

                                                                                        Sorry the fiqure would not post. If you access the article it is figure 1a.

                                                                                        Brent Morris
                                                                                        Participant

                                                                                          Sorry the fiqure would not post. If you access the article it is figure 1a.

                                                                                          Brent Morris
                                                                                          Participant

                                                                                            Sorry the fiqure would not post. If you access the article it is figure 1a.

                                                                                            Brent Morris
                                                                                            Participant

                                                                                              I think you will find the statistics in this reference.

                                                                                               

                                                                                              Arch Surg. Author manuscript; available in PMC 2011 February 1.
                                                                                              Published in final edited form as:

                                                                                              PMCID: PMC2880665
                                                                                              NIHMSID: NIHMS192811

                                                                                              Predictors of Occult Nodal Metastasis in Patients with Thin Melanoma

                                                                                              Abstract

                                                                                              Background and Hypothesis

                                                                                              Although thin primary lesions are largely responsible for the rapid increase in melanoma incidence, making identification of appropriate candidates for nodal staging in this group critically important. We hypothesized that common clinical parameters may accurately estimate the risk of nodal metastasis after wide excision and determine the need for sentinel node (SN) biopsy.

                                                                                              Design and Setting

                                                                                              Review of prospectively acquired data in the large melanoma database at a tertiary referral center

                                                                                              Patients and Methods

                                                                                              We identified patients seen within 6 months of diagnosis of thin (<1 mm) melanoma and treated by wide excision alone. We examined the rate of regional nodal recurrence and the impact of clinical/demographic variables by univariate and multivariate analyses.

                                                                                              Results

                                                                                              The overall nodal recurrence rate was 2.9%; median time to recurrence was 38.3 months. Univariate analysis of 1732 patients identified male sex (p<0.001), increased Breslow thickness (p<0.001), and increased Clark level (p<0.001) as significant for nodal recurrence. Multivariate analysis identified male sex (p=0.0005, HR 3.5), younger age (p=0.0019, HR 0.45), and increased Breslow thickness (categorical, p<0.001, HR 2.47) as significant. Clark was no longer significant (p=0.6). Breslow thickness, age and sex were used to develop a scoring system and nomogram for the risk of nodal involvement: predictions ranged from 0.1% in the lowest risk group to 17.4% in the highest risk group.

                                                                                              Conclusion

                                                                                              Many patients with thin melanoma will have nodal recurrence after wide excision alone. Three simple clinical parameters may be used to estimate recurrence risk and select patients for SN biopsy.

                                                                                               

                                                                                              It includes this figure:

                                                                                               

                                                                                              An external file that holds a picture, illustration, etc.
Object name is nihms192811f1.jpg

                                                                                               

                                                                                              Brent Morris
                                                                                              Participant

                                                                                                I think you will find the statistics in this reference.

                                                                                                 

                                                                                                Arch Surg. Author manuscript; available in PMC 2011 February 1.
                                                                                                Published in final edited form as:

                                                                                                PMCID: PMC2880665
                                                                                                NIHMSID: NIHMS192811

                                                                                                Predictors of Occult Nodal Metastasis in Patients with Thin Melanoma

                                                                                                Abstract

                                                                                                Background and Hypothesis

                                                                                                Although thin primary lesions are largely responsible for the rapid increase in melanoma incidence, making identification of appropriate candidates for nodal staging in this group critically important. We hypothesized that common clinical parameters may accurately estimate the risk of nodal metastasis after wide excision and determine the need for sentinel node (SN) biopsy.

                                                                                                Design and Setting

                                                                                                Review of prospectively acquired data in the large melanoma database at a tertiary referral center

                                                                                                Patients and Methods

                                                                                                We identified patients seen within 6 months of diagnosis of thin (<1 mm) melanoma and treated by wide excision alone. We examined the rate of regional nodal recurrence and the impact of clinical/demographic variables by univariate and multivariate analyses.

                                                                                                Results

                                                                                                The overall nodal recurrence rate was 2.9%; median time to recurrence was 38.3 months. Univariate analysis of 1732 patients identified male sex (p<0.001), increased Breslow thickness (p<0.001), and increased Clark level (p<0.001) as significant for nodal recurrence. Multivariate analysis identified male sex (p=0.0005, HR 3.5), younger age (p=0.0019, HR 0.45), and increased Breslow thickness (categorical, p<0.001, HR 2.47) as significant. Clark was no longer significant (p=0.6). Breslow thickness, age and sex were used to develop a scoring system and nomogram for the risk of nodal involvement: predictions ranged from 0.1% in the lowest risk group to 17.4% in the highest risk group.

                                                                                                Conclusion

                                                                                                Many patients with thin melanoma will have nodal recurrence after wide excision alone. Three simple clinical parameters may be used to estimate recurrence risk and select patients for SN biopsy.

                                                                                                 

                                                                                                It includes this figure:

                                                                                                 

                                                                                                An external file that holds a picture, illustration, etc.
Object name is nihms192811f1.jpg

                                                                                                 

                                                                                                JC
                                                                                                Participant

                                                                                                  where do you see " age less than forty years"?

                                                                                                  JC
                                                                                                  Participant

                                                                                                    where do you see " age less than forty years"?

                                                                                                    Brent Morris
                                                                                                    Participant

                                                                                                      There has been debate in the literature about whether to do an SNB in thin melanomas (less than 0.76-1mm). However, some data have shown a positive rate as high as 5% in young patients with thin lesions. Attempts have been made to find distinquishing characteristics. The presence of a mitotic rate greater than 0, a vertical growth phase, clark level 4, male sex, and age less than forty years may all be factors. Below are two relevant references which support this counter intuitive phenomena.

                                                                                                      Incidence of Sentinel Node Metastasis in Patients With Thin Primary Melanoma (#1 mm) With Vertical Growth Phase

                                                                                                      Abstract

                                                                                                      Background: Patients with thin primary melanomas (#1 mm) generally have an excellent prognosis. However, the presence of a vertical growth phase (VGP) adversely impacts the survival rate. We report on the rate of occurrence of nodal metastasis in patients with thin primary melanomas with a VGP who are offered sentinel lymph node (SLN) biopsy.

                                                                                                      Methods: Among 235 patients with clinically localized cutaneous melanomas who underwent successful SLN biopsy, 71 had lesions 1 mm or smaller with a VGP. The SLN was localized by using blue dye and a radiotracer. If negative for tumor by using hematoxylin and eosin staining, the SLN was further examined by immunohistochemistry.

                                                                                                      Results: The rate of occurrence of SLN metastasis was 15.2% in patients with melanomas deeper than 1 mm and 5.6% in patients with thin melanomas. Three patients with thin melanomas and a positive SLN had low-risk lesions, based on a highly accurate six-variable multivariate logistic regression model for predicting 8-year survival in stage I/II melanomas. The fourth patient had a low- to intermediate-risk lesion based on this model. At the time of the lymphadenectomy, one patient had two additional nodes with metastasis.

                                                                                                      Conclusions: VGP in a melanoma 1 mm or smaller seems to be a risk factor for nodal metastasis. The risk of nodal disease may not be accurately predicted by the use of a multivariate logistic regression model that incorporates thickness, mitotic rate, regression, tumor-infiltrating lymphocytes, sex, and anatomical site. Patients with thin lesions having VGP should be evaluated for SLN biopsy and trials of adjuvant therapy when stage III disease is found.

                                                                                                      Presented at the 52nd Annual Meeting of the Society of Surgical Oncology, Orlando, Florida, March 4–7, 1999.
                                                                                                       
                                                                                                      ___________________________________________________________________________________
                                                                                                       
                                                                                                      Ann Surg Oncol. 2014 Feb 15. [Epub ahead of print]

                                                                                                      Age as a Predictor of Sentinel Node Metastasis among Patients with Localized Melanoma: An Inverse Correlation of Melanoma Mortality and Incidence of Sentinel Node Metastasis Among Young and Old Patients.

                                                                                                      Abstract

                                                                                                      PURPOSE:

                                                                                                      We have previously reported that older patients with clinical stage I and II primary cutaneous. Melanoma had lower survival rates compared to younger patients. We postulated that the incidence of nodal metastasis would therefore be higher among older melanoma patients.

                                                                                                      METHODS:

                                                                                                      The expanded American Joint Committee on Cancer melanoma staging database contains a cohort of 7,756 melanoma patients who presented without clinical evidence of regional lymph node or distant metastasis and who underwent a sentinel node biopsy procedure as a component of their staging assessment.

                                                                                                      RESULTS:

                                                                                                      Although older patients had primary melanoma features associated with more aggressive biology, we paradoxically observed a significant decrease in the incidence of sentinel node metastasis as patient age increased. Overall, the highest incidence of sentinel node metastasis was 25.8 % in patients under 20 years of age, compared to 15.5 % in patients 80 years and older (p < 0.001). In contrast, 5-year mortality rates for clinical stage II patients ranged from a low of 20 % for those 20-40 years of age up to 38 % for those over 70 years of age. Patient age was an independent predictor of sentinel node metastasis in a multifactorial analysis (p < 0.001).

                                                                                                      CONCLUSIONS:

                                                                                                      Patients with clinical stage I and II melanoma under 20 years of age had a higher incidence of sentinel lymph node metastasis but, paradoxically, a more favorable survival outcome compared to all other age groups. In contrast, patients >70 years had the most aggressive primary melanoma features and a higher mortality rate compared to all other age groups but a lower incidence of sentinel lymph node metastasis.

                                                                                                       

                                                                                                      Brent Morris
                                                                                                      Participant

                                                                                                        There has been debate in the literature about whether to do an SNB in thin melanomas (less than 0.76-1mm). However, some data have shown a positive rate as high as 5% in young patients with thin lesions. Attempts have been made to find distinquishing characteristics. The presence of a mitotic rate greater than 0, a vertical growth phase, clark level 4, male sex, and age less than forty years may all be factors. Below are two relevant references which support this counter intuitive phenomena.

                                                                                                        Incidence of Sentinel Node Metastasis in Patients With Thin Primary Melanoma (#1 mm) With Vertical Growth Phase

                                                                                                        Abstract

                                                                                                        Background: Patients with thin primary melanomas (#1 mm) generally have an excellent prognosis. However, the presence of a vertical growth phase (VGP) adversely impacts the survival rate. We report on the rate of occurrence of nodal metastasis in patients with thin primary melanomas with a VGP who are offered sentinel lymph node (SLN) biopsy.

                                                                                                        Methods: Among 235 patients with clinically localized cutaneous melanomas who underwent successful SLN biopsy, 71 had lesions 1 mm or smaller with a VGP. The SLN was localized by using blue dye and a radiotracer. If negative for tumor by using hematoxylin and eosin staining, the SLN was further examined by immunohistochemistry.

                                                                                                        Results: The rate of occurrence of SLN metastasis was 15.2% in patients with melanomas deeper than 1 mm and 5.6% in patients with thin melanomas. Three patients with thin melanomas and a positive SLN had low-risk lesions, based on a highly accurate six-variable multivariate logistic regression model for predicting 8-year survival in stage I/II melanomas. The fourth patient had a low- to intermediate-risk lesion based on this model. At the time of the lymphadenectomy, one patient had two additional nodes with metastasis.

                                                                                                        Conclusions: VGP in a melanoma 1 mm or smaller seems to be a risk factor for nodal metastasis. The risk of nodal disease may not be accurately predicted by the use of a multivariate logistic regression model that incorporates thickness, mitotic rate, regression, tumor-infiltrating lymphocytes, sex, and anatomical site. Patients with thin lesions having VGP should be evaluated for SLN biopsy and trials of adjuvant therapy when stage III disease is found.

                                                                                                        Presented at the 52nd Annual Meeting of the Society of Surgical Oncology, Orlando, Florida, March 4–7, 1999.
                                                                                                         
                                                                                                        ___________________________________________________________________________________
                                                                                                         
                                                                                                        Ann Surg Oncol. 2014 Feb 15. [Epub ahead of print]

                                                                                                        Age as a Predictor of Sentinel Node Metastasis among Patients with Localized Melanoma: An Inverse Correlation of Melanoma Mortality and Incidence of Sentinel Node Metastasis Among Young and Old Patients.

                                                                                                        Abstract

                                                                                                        PURPOSE:

                                                                                                        We have previously reported that older patients with clinical stage I and II primary cutaneous. Melanoma had lower survival rates compared to younger patients. We postulated that the incidence of nodal metastasis would therefore be higher among older melanoma patients.

                                                                                                        METHODS:

                                                                                                        The expanded American Joint Committee on Cancer melanoma staging database contains a cohort of 7,756 melanoma patients who presented without clinical evidence of regional lymph node or distant metastasis and who underwent a sentinel node biopsy procedure as a component of their staging assessment.

                                                                                                        RESULTS:

                                                                                                        Although older patients had primary melanoma features associated with more aggressive biology, we paradoxically observed a significant decrease in the incidence of sentinel node metastasis as patient age increased. Overall, the highest incidence of sentinel node metastasis was 25.8 % in patients under 20 years of age, compared to 15.5 % in patients 80 years and older (p < 0.001). In contrast, 5-year mortality rates for clinical stage II patients ranged from a low of 20 % for those 20-40 years of age up to 38 % for those over 70 years of age. Patient age was an independent predictor of sentinel node metastasis in a multifactorial analysis (p < 0.001).

                                                                                                        CONCLUSIONS:

                                                                                                        Patients with clinical stage I and II melanoma under 20 years of age had a higher incidence of sentinel lymph node metastasis but, paradoxically, a more favorable survival outcome compared to all other age groups. In contrast, patients >70 years had the most aggressive primary melanoma features and a higher mortality rate compared to all other age groups but a lower incidence of sentinel lymph node metastasis.

                                                                                                         

                                                                                                        JC
                                                                                                        Participant

                                                                                                          “Thin melanomas in young individuals can sometimes be more aggressive.”

                                                                                                          More so, for some reason, than others?  Why would that be?

                                                                                                          JC
                                                                                                          Participant

                                                                                                            “Thin melanomas in young individuals can sometimes be more aggressive.”

                                                                                                            More so, for some reason, than others?  Why would that be?

                                                                                                            Brent Morris
                                                                                                            Participant

                                                                                                              To be accurate Breslow refers to the thickness of the tumor and the depth (or penetration into the skin) is the Clark level. In your instance both are at the lower (good) end of the scales. In spite of the early character of this melanoma I would not take it lightly. The descripton of the margins needs to be discussed. Sometimes a reexcision is done to ensure adequate margins.Thin melanomas in young individuals can sometimes be more aggressive. All the more reason to seek out a melanoma specialist. Martin Mihm is one of the best dermatopathologists in the world. You have started at a good place.

                                                                                                              Brent Morris
                                                                                                              Participant

                                                                                                                To be accurate Breslow refers to the thickness of the tumor and the depth (or penetration into the skin) is the Clark level. In your instance both are at the lower (good) end of the scales. In spite of the early character of this melanoma I would not take it lightly. The descripton of the margins needs to be discussed. Sometimes a reexcision is done to ensure adequate margins.Thin melanomas in young individuals can sometimes be more aggressive. All the more reason to seek out a melanoma specialist. Martin Mihm is one of the best dermatopathologists in the world. You have started at a good place.

                                                                                                              Janner
                                                                                                              Participant

                                                                                                                First, congratulations on your pregnancy.

                                                                                                                Second, melanoma.  The one thing you don't mention in your path report is if there is any mitosis or mitotic rate?  Regardless, this is just going to be a little minor surgery.  They will do some local anesthetic injections and remove a good chunk of skin around where the mole was.  It can all be done in an office setting with local anesthesia.  Once done, it shouldn't hinder anything to do with your pregnancy. 

                                                                                                                Now, the caveat.  Since you are pregnant, moles often darken and change during pregnancy.  You will want to be more vigilant watching for moles that change and see your derm often – just to stay on top of things.  Your prognosis is very good with the first melanoma once it is surgically removed with larger margins.  But you will need to stay on top of your other moles to make sure any other suspicious lesions are biopsied.  Since pregnancy causes changes, this is very important.

                                                                                                                I had a deeper melanoma (0.58mm) removed in 1992… and I'm still here and still stage I.  Just for perspective.  Take a deep breath and hang in there.  Find a good dermatologist whose specialty extends beyond botox to skin cancer  🙂 and schedule an appointment.  Ask any other questions you have here and we'll try to help.

                                                                                                                Best wishes,

                                                                                                                Janner

                                                                                                                Janner
                                                                                                                Participant

                                                                                                                  First, congratulations on your pregnancy.

                                                                                                                  Second, melanoma.  The one thing you don't mention in your path report is if there is any mitosis or mitotic rate?  Regardless, this is just going to be a little minor surgery.  They will do some local anesthetic injections and remove a good chunk of skin around where the mole was.  It can all be done in an office setting with local anesthesia.  Once done, it shouldn't hinder anything to do with your pregnancy. 

                                                                                                                  Now, the caveat.  Since you are pregnant, moles often darken and change during pregnancy.  You will want to be more vigilant watching for moles that change and see your derm often – just to stay on top of things.  Your prognosis is very good with the first melanoma once it is surgically removed with larger margins.  But you will need to stay on top of your other moles to make sure any other suspicious lesions are biopsied.  Since pregnancy causes changes, this is very important.

                                                                                                                  I had a deeper melanoma (0.58mm) removed in 1992… and I'm still here and still stage I.  Just for perspective.  Take a deep breath and hang in there.  Find a good dermatologist whose specialty extends beyond botox to skin cancer  🙂 and schedule an appointment.  Ask any other questions you have here and we'll try to help.

                                                                                                                  Best wishes,

                                                                                                                  Janner

                                                                                                                  Janner
                                                                                                                  Participant

                                                                                                                    First, congratulations on your pregnancy.

                                                                                                                    Second, melanoma.  The one thing you don't mention in your path report is if there is any mitosis or mitotic rate?  Regardless, this is just going to be a little minor surgery.  They will do some local anesthetic injections and remove a good chunk of skin around where the mole was.  It can all be done in an office setting with local anesthesia.  Once done, it shouldn't hinder anything to do with your pregnancy. 

                                                                                                                    Now, the caveat.  Since you are pregnant, moles often darken and change during pregnancy.  You will want to be more vigilant watching for moles that change and see your derm often – just to stay on top of things.  Your prognosis is very good with the first melanoma once it is surgically removed with larger margins.  But you will need to stay on top of your other moles to make sure any other suspicious lesions are biopsied.  Since pregnancy causes changes, this is very important.

                                                                                                                    I had a deeper melanoma (0.58mm) removed in 1992… and I'm still here and still stage I.  Just for perspective.  Take a deep breath and hang in there.  Find a good dermatologist whose specialty extends beyond botox to skin cancer  🙂 and schedule an appointment.  Ask any other questions you have here and we'll try to help.

                                                                                                                    Best wishes,

                                                                                                                    Janner

                                                                                                                    sunshinlilyrose
                                                                                                                    Participant

                                                                                                                      Again I cannot thank everyone enough for all this nformation. I received the rest of the report today and if anyone can tell me anything else from this that would be great!

                                                                                                                      Comment: 

                                                                                                                      this leision is definitely superficial spreading melanoma. It exhibits quie prominent pagetoid.and shows several fool (sp? It's blurry on fax) of microinvasion. There are no mitosis, ulceration or regression. The lesion arises in a background of a dysplastic nevus. The Mart-1 stain exhibits clearly the extent of the melanoma as well as the precursor legion. The Ki67 shows an increased epidermal and dermal signal. I recommend a re-excision with a 1.0 margin and careful follow up of patient.

                                                                                                                       

                                                                                                                      ok so this was the rest of the pathology report I finally got.  Does anyone know what a Mart-1 is and a Ki67?

                                                                                                                      sunshinlilyrose
                                                                                                                      Participant

                                                                                                                        Again I cannot thank everyone enough for all this nformation. I received the rest of the report today and if anyone can tell me anything else from this that would be great!

                                                                                                                        Comment: 

                                                                                                                        this leision is definitely superficial spreading melanoma. It exhibits quie prominent pagetoid.and shows several fool (sp? It's blurry on fax) of microinvasion. There are no mitosis, ulceration or regression. The lesion arises in a background of a dysplastic nevus. The Mart-1 stain exhibits clearly the extent of the melanoma as well as the precursor legion. The Ki67 shows an increased epidermal and dermal signal. I recommend a re-excision with a 1.0 margin and careful follow up of patient.

                                                                                                                         

                                                                                                                        ok so this was the rest of the pathology report I finally got.  Does anyone know what a Mart-1 is and a Ki67?

                                                                                                                        sunshinlilyrose
                                                                                                                        Participant

                                                                                                                          Again I cannot thank everyone enough for all this nformation. I received the rest of the report today and if anyone can tell me anything else from this that would be great!

                                                                                                                          Comment: 

                                                                                                                          this leision is definitely superficial spreading melanoma. It exhibits quie prominent pagetoid.and shows several fool (sp? It's blurry on fax) of microinvasion. There are no mitosis, ulceration or regression. The lesion arises in a background of a dysplastic nevus. The Mart-1 stain exhibits clearly the extent of the melanoma as well as the precursor legion. The Ki67 shows an increased epidermal and dermal signal. I recommend a re-excision with a 1.0 margin and careful follow up of patient.

                                                                                                                           

                                                                                                                          ok so this was the rest of the pathology report I finally got.  Does anyone know what a Mart-1 is and a Ki67?

                                                                                                                            JC
                                                                                                                            Participant

                                                                                                                              I guess I'm wondering what " careful follow up of patient" means. . many doctors wouldn't do bloodwork nor scans for your stage (1A), so other than dermatologist appointments and checking lymph nodes at physicals, what else is the followup?

                                                                                                                              JC
                                                                                                                              Participant

                                                                                                                                I guess I'm wondering what " careful follow up of patient" means. . many doctors wouldn't do bloodwork nor scans for your stage (1A), so other than dermatologist appointments and checking lymph nodes at physicals, what else is the followup?

                                                                                                                                JC
                                                                                                                                Participant

                                                                                                                                  I guess I'm wondering what " careful follow up of patient" means. . many doctors wouldn't do bloodwork nor scans for your stage (1A), so other than dermatologist appointments and checking lymph nodes at physicals, what else is the followup?

                                                                                                                                  sunshinlilyrose
                                                                                                                                  Participant

                                                                                                                                    Lol no idea….this is all new to me. I have an appt next Friday at the cancer institute of nj ( they were able to get me on quicker then Sloan Kettering so I guess that's when I'll get me answers . Do you know what anything on there means?

                                                                                                                                    sunshinlilyrose
                                                                                                                                    Participant

                                                                                                                                      Lol no idea….this is all new to me. I have an appt next Friday at the cancer institute of nj ( they were able to get me on quicker then Sloan Kettering so I guess that's when I'll get me answers . Do you know what anything on there means?

                                                                                                                                      sunshinlilyrose
                                                                                                                                      Participant

                                                                                                                                        Lol no idea….this is all new to me. I have an appt next Friday at the cancer institute of nj ( they were able to get me on quicker then Sloan Kettering so I guess that's when I'll get me answers . Do you know what anything on there means?

                                                                                                                                        sunshinlilyrose
                                                                                                                                        Participant

                                                                                                                                          Honestly, I have no idea, this s day 2 of dealing with this for me. I did get an appointment for next Friday at the cancer institute of nj ( they were able to get me in earlier then Sloan Kettering .  I am hoping to get answers and info as I feel lost and being pregnant is definitely not helping any. Do you understand what anything else on the report means. Also, I have like 4 more odd moles and patches that I didn't show my primary ( she took off the cancerous one) and now I'm very worried about those as well.

                                                                                                                                          sunshinlilyrose
                                                                                                                                          Participant

                                                                                                                                            Honestly, I have no idea, this s day 2 of dealing with this for me. I did get an appointment for next Friday at the cancer institute of nj ( they were able to get me in earlier then Sloan Kettering .  I am hoping to get answers and info as I feel lost and being pregnant is definitely not helping any. Do you understand what anything else on the report means. Also, I have like 4 more odd moles and patches that I didn't show my primary ( she took off the cancerous one) and now I'm very worried about those as well.

                                                                                                                                            sunshinlilyrose
                                                                                                                                            Participant

                                                                                                                                              Honestly, I have no idea, this s day 2 of dealing with this for me. I did get an appointment for next Friday at the cancer institute of nj ( they were able to get me in earlier then Sloan Kettering .  I am hoping to get answers and info as I feel lost and being pregnant is definitely not helping any. Do you understand what anything else on the report means. Also, I have like 4 more odd moles and patches that I didn't show my primary ( she took off the cancerous one) and now I'm very worried about those as well.

                                                                                                                                              sunshinlilyrose
                                                                                                                                              Participant

                                                                                                                                                Thanks again for all the helpful info

                                                                                                                                                sunshinlilyrose
                                                                                                                                                Participant

                                                                                                                                                  Thanks again for all the helpful info

                                                                                                                                                  sunshinlilyrose
                                                                                                                                                  Participant

                                                                                                                                                    Thanks again for all the helpful info

                                                                                                                                                    Janner
                                                                                                                                                    Participant

                                                                                                                                                      Mart1 is essentially a stain – a method to make identifying melanocytes easier.  You are stage 1a.  You need a derm.  You need a wide local excision (WLE).  You don't need blood work, an oncologist or anything else.  You do need careful follow up because moles change during pregnancy.  Most melanoma warriors only have one primary melanoma.  Are your other moles similar to each other?  You are really looking for the ugly duckling.  Watch for CHANGE, that is the most important thing for your other moles.  In the meantime, try not to stress this.  (Not easy, I know).  But this is truly a very low risk lesion and your prognosis is extremely good.

                                                                                                                                                      Janner
                                                                                                                                                      Participant

                                                                                                                                                        Mart1 is essentially a stain – a method to make identifying melanocytes easier.  You are stage 1a.  You need a derm.  You need a wide local excision (WLE).  You don't need blood work, an oncologist or anything else.  You do need careful follow up because moles change during pregnancy.  Most melanoma warriors only have one primary melanoma.  Are your other moles similar to each other?  You are really looking for the ugly duckling.  Watch for CHANGE, that is the most important thing for your other moles.  In the meantime, try not to stress this.  (Not easy, I know).  But this is truly a very low risk lesion and your prognosis is extremely good.

                                                                                                                                                        Janner
                                                                                                                                                        Participant

                                                                                                                                                          Mart1 is essentially a stain – a method to make identifying melanocytes easier.  You are stage 1a.  You need a derm.  You need a wide local excision (WLE).  You don't need blood work, an oncologist or anything else.  You do need careful follow up because moles change during pregnancy.  Most melanoma warriors only have one primary melanoma.  Are your other moles similar to each other?  You are really looking for the ugly duckling.  Watch for CHANGE, that is the most important thing for your other moles.  In the meantime, try not to stress this.  (Not easy, I know).  But this is truly a very low risk lesion and your prognosis is extremely good.

                                                                                                                                                          sunshinlilyrose
                                                                                                                                                          Participant

                                                                                                                                                            Ok one more question….. After I have more area removed am I then considered cancer free?? Like it's just gone and I'm healed? Trying hard to understand as we have never had this form in my family only ovarian which is very different. Should I not have made my focuses appt at the cancer center with the melanoma specialist… Would a derm be better?

                                                                                                                                                            sunshinlilyrose
                                                                                                                                                            Participant

                                                                                                                                                              Ok one more question….. After I have more area removed am I then considered cancer free?? Like it's just gone and I'm healed? Trying hard to understand as we have never had this form in my family only ovarian which is very different. Should I not have made my focuses appt at the cancer center with the melanoma specialist… Would a derm be better?

                                                                                                                                                              sunshinlilyrose
                                                                                                                                                              Participant

                                                                                                                                                                Ok one more question….. After I have more area removed am I then considered cancer free?? Like it's just gone and I'm healed? Trying hard to understand as we have never had this form in my family only ovarian which is very different. Should I not have made my focuses appt at the cancer center with the melanoma specialist… Would a derm be better?

                                                                                                                                                                sunshinlilyrose
                                                                                                                                                                Participant

                                                                                                                                                                  Typo meant first appointment not focuses…lol

                                                                                                                                                                  sunshinlilyrose
                                                                                                                                                                  Participant

                                                                                                                                                                    Typo meant first appointment not focuses…lol

                                                                                                                                                                    sunshinlilyrose
                                                                                                                                                                    Participant

                                                                                                                                                                      Typo meant first appointment not focuses…lol

                                                                                                                                                                      Janner
                                                                                                                                                                      Participant

                                                                                                                                                                        Many oncologist won't even see stage 1a patients.  They treat active disease.   I prefer a good derm to work with.  One you have the surgery, you will be considered NED – no evidence of disease.  There really is no "cure" for melanoma as it could come back many years later.  But for stage 1a, the survival rates are in the high nineties – say 97% or thereabouts.  It isn't 100% and there isn't a five year "I'm free".  Your risk is extremely low, but not gone.  Your risk of getting another primary is higher, about 8-9%.  So the key is to be realistic about your odds.  They are good.  That is the main thing to live by.  But you also need to be vigilant..my motto is "vigilant but not paranoid".  This gets easier with time.  I have a private yahoo email list for stage one individuals if you are interested.  All have been in your shoes at one time.  If you are interested, click on my name and go to my profile and email me.

                                                                                                                                                                        janner

                                                                                                                                                                        Janner
                                                                                                                                                                        Participant

                                                                                                                                                                          Many oncologist won't even see stage 1a patients.  They treat active disease.   I prefer a good derm to work with.  One you have the surgery, you will be considered NED – no evidence of disease.  There really is no "cure" for melanoma as it could come back many years later.  But for stage 1a, the survival rates are in the high nineties – say 97% or thereabouts.  It isn't 100% and there isn't a five year "I'm free".  Your risk is extremely low, but not gone.  Your risk of getting another primary is higher, about 8-9%.  So the key is to be realistic about your odds.  They are good.  That is the main thing to live by.  But you also need to be vigilant..my motto is "vigilant but not paranoid".  This gets easier with time.  I have a private yahoo email list for stage one individuals if you are interested.  All have been in your shoes at one time.  If you are interested, click on my name and go to my profile and email me.

                                                                                                                                                                          janner

                                                                                                                                                                          Janner
                                                                                                                                                                          Participant

                                                                                                                                                                            Many oncologist won't even see stage 1a patients.  They treat active disease.   I prefer a good derm to work with.  One you have the surgery, you will be considered NED – no evidence of disease.  There really is no "cure" for melanoma as it could come back many years later.  But for stage 1a, the survival rates are in the high nineties – say 97% or thereabouts.  It isn't 100% and there isn't a five year "I'm free".  Your risk is extremely low, but not gone.  Your risk of getting another primary is higher, about 8-9%.  So the key is to be realistic about your odds.  They are good.  That is the main thing to live by.  But you also need to be vigilant..my motto is "vigilant but not paranoid".  This gets easier with time.  I have a private yahoo email list for stage one individuals if you are interested.  All have been in your shoes at one time.  If you are interested, click on my name and go to my profile and email me.

                                                                                                                                                                            janner

                                                                                                                                                                            JC
                                                                                                                                                                            Participant

                                                                                                                                                                              " it could come back many years later"

                                                                                                                                                                              Is that because it never really left to begin with after surgery?  Or because in a small % of people cells broke off and traveled before the WLE?

                                                                                                                                                                              JC
                                                                                                                                                                              Participant

                                                                                                                                                                                " it could come back many years later"

                                                                                                                                                                                Is that because it never really left to begin with after surgery?  Or because in a small % of people cells broke off and traveled before the WLE?

                                                                                                                                                                                JC
                                                                                                                                                                                Participant

                                                                                                                                                                                  " it could come back many years later"

                                                                                                                                                                                  Is that because it never really left to begin with after surgery?  Or because in a small % of people cells broke off and traveled before the WLE?

                                                                                                                                                                                  JC
                                                                                                                                                                                  Participant

                                                                                                                                                                                    Is that to say 97% are cancer free "cured" after surgery, but about 3% aren't?  Or is that to say 100% aren't cancer free "cured" after surgery, but in 3% what has been left behind goes on to cause problems later?  I'm confused.

                                                                                                                                                                                    JC
                                                                                                                                                                                    Participant

                                                                                                                                                                                      Is that to say 97% are cancer free "cured" after surgery, but about 3% aren't?  Or is that to say 100% aren't cancer free "cured" after surgery, but in 3% what has been left behind goes on to cause problems later?  I'm confused.

                                                                                                                                                                                      JC
                                                                                                                                                                                      Participant

                                                                                                                                                                                        Is that to say 97% are cancer free "cured" after surgery, but about 3% aren't?  Or is that to say 100% aren't cancer free "cured" after surgery, but in 3% what has been left behind goes on to cause problems later?  I'm confused.

                                                                                                                                                                                        JC
                                                                                                                                                                                        Participant

                                                                                                                                                                                          If it can come back many years later, 10 years, 15 years, etc. . then what it the point of a 5 year survival rate?  Sure, maybe it's high, but that's because it takes longer than 5 years to come back, seems like a misleading stat.

                                                                                                                                                                                          Janner
                                                                                                                                                                                          Participant

                                                                                                                                                                                            Survival curves always get better over time.  So yes, there is a small percentage that have their melanoma return years later.  There is no "you are cured after 5 years".  Again, the curves improve over time.  The further out you are, the better your odds.  Nothing is a guarantee.

                                                                                                                                                                                            Janner
                                                                                                                                                                                            Participant

                                                                                                                                                                                              Survival curves always get better over time.  So yes, there is a small percentage that have their melanoma return years later.  There is no "you are cured after 5 years".  Again, the curves improve over time.  The further out you are, the better your odds.  Nothing is a guarantee.

                                                                                                                                                                                              Janner
                                                                                                                                                                                              Participant

                                                                                                                                                                                                Survival curves always get better over time.  So yes, there is a small percentage that have their melanoma return years later.  There is no "you are cured after 5 years".  Again, the curves improve over time.  The further out you are, the better your odds.  Nothing is a guarantee.

                                                                                                                                                                                                JC
                                                                                                                                                                                                Participant

                                                                                                                                                                                                  If it can come back many years later, 10 years, 15 years, etc. . then what it the point of a 5 year survival rate?  Sure, maybe it's high, but that's because it takes longer than 5 years to come back, seems like a misleading stat.

                                                                                                                                                                                                  JC
                                                                                                                                                                                                  Participant

                                                                                                                                                                                                    If it can come back many years later, 10 years, 15 years, etc. . then what it the point of a 5 year survival rate?  Sure, maybe it's high, but that's because it takes longer than 5 years to come back, seems like a misleading stat.

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                                                                                                                                                                                              The MRF Patient Forum is the oldest and largest online community of people affected by melanoma. It is designed to provide peer support and information to caregivers, patients, family and friends. There is no better place to discuss different parts of your journey with this cancer and find the friends and support resources to make that journey more bearable.

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