› Forums › Cutaneous Melanoma Community › Newly diagnosed and pregnant
- This topic has 93 replies, 9 voices, and was last updated 11 years, 3 months ago by
Janner.
- Post
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- February 21, 2014 at 11:22 am
Hi all, so I had a weird growth on my lower hip for a while and finally had it biopsied. My primary called me yesterday to tell me it is melanoma and told me to see a Dermotologist with a speciality in skin cancers. She faxed me over the pathology report but I don't really understand it. I would appreciate any help deciphering it. I also found out I am 7 weeks pregnant and am wondering if this is going to hinder any additional tests I may need…..smh….very stressed. Ok, this is what my report says
malignant melanoma, superficial spreading type, invasive to level 2 and a measured thickness of 0.4mm, arising in the background of a compound dysplastic nevus with severe atypia, close to lateral and deep margins. ( please see consultation report from dr Martin c. Mihm of Harvard )
ok so above is exactly what mine said, including the parentheses, which btw I did not get a copy of that report.
Thanks all!!!
- Replies
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- February 21, 2014 at 12:29 pm
I was diagnosed when I was 20 weeks pregnant with my daughter so I understand how stressed you are feeling. The good news is that you have a very thin melanoma which carries an excellent prognosis!
If I were you I would find a dermotologist who specializes in melanoma. I am no sure what area you live in, but I think Boston since you had a consultation report from Harvard. Dana Farber in Boston is great and maybe others can chime in with more melanoma center options. You will have another surgery to get wider margins around the area of the melanoma. This was out patient with local anastesia for me. Because your melanoma is so thin I would be surprised if they wanted to remove any lymph nodes. In general, if you are stage IA, which it looks like from your report, being pregnant with not hinder any additional tests. Normally, you will need to return to your dermotologist every three months to get checked out, which is not an issue while pregnant.
I wish you all the best and good luck!
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- February 21, 2014 at 12:29 pm
I was diagnosed when I was 20 weeks pregnant with my daughter so I understand how stressed you are feeling. The good news is that you have a very thin melanoma which carries an excellent prognosis!
If I were you I would find a dermotologist who specializes in melanoma. I am no sure what area you live in, but I think Boston since you had a consultation report from Harvard. Dana Farber in Boston is great and maybe others can chime in with more melanoma center options. You will have another surgery to get wider margins around the area of the melanoma. This was out patient with local anastesia for me. Because your melanoma is so thin I would be surprised if they wanted to remove any lymph nodes. In general, if you are stage IA, which it looks like from your report, being pregnant with not hinder any additional tests. Normally, you will need to return to your dermotologist every three months to get checked out, which is not an issue while pregnant.
I wish you all the best and good luck!
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- February 21, 2014 at 12:29 pm
I was diagnosed when I was 20 weeks pregnant with my daughter so I understand how stressed you are feeling. The good news is that you have a very thin melanoma which carries an excellent prognosis!
If I were you I would find a dermotologist who specializes in melanoma. I am no sure what area you live in, but I think Boston since you had a consultation report from Harvard. Dana Farber in Boston is great and maybe others can chime in with more melanoma center options. You will have another surgery to get wider margins around the area of the melanoma. This was out patient with local anastesia for me. Because your melanoma is so thin I would be surprised if they wanted to remove any lymph nodes. In general, if you are stage IA, which it looks like from your report, being pregnant with not hinder any additional tests. Normally, you will need to return to your dermotologist every three months to get checked out, which is not an issue while pregnant.
I wish you all the best and good luck!
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- February 21, 2014 at 12:46 pm
Thanks so much for the response….I didn't sleep very well last night. How can you tell it is thin? I actually live in nj but thanks for the info. My primary recommended someone to me I'm just waiting until they open. Let me tell you after reading online I was pretty sure this was a death sentence so I was very happy to come across this sight. Does anyone know if there are specific tests I should ask doctor to perform. Thanks again for all the info.
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- February 21, 2014 at 12:46 pm
Thanks so much for the response….I didn't sleep very well last night. How can you tell it is thin? I actually live in nj but thanks for the info. My primary recommended someone to me I'm just waiting until they open. Let me tell you after reading online I was pretty sure this was a death sentence so I was very happy to come across this sight. Does anyone know if there are specific tests I should ask doctor to perform. Thanks again for all the info.
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- February 21, 2014 at 12:46 pm
Thanks so much for the response….I didn't sleep very well last night. How can you tell it is thin? I actually live in nj but thanks for the info. My primary recommended someone to me I'm just waiting until they open. Let me tell you after reading online I was pretty sure this was a death sentence so I was very happy to come across this sight. Does anyone know if there are specific tests I should ask doctor to perform. Thanks again for all the info.
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- February 21, 2014 at 1:10 pm
This is not a death sentence! It states in the pathology report that the thickness of the melanoma is .4mm. Anything under 1 mm with a low miotic rate that isn't ulcerated is considered stage 1a. The basic thinking is the thinner the melanoma the better the outcome.
I went to the Sloan Kettering Melanoma Clinic which is in Long Island, which might not be too far from you depending where in Jersey you are. They were really great. I would definitely ask about a Sentinal Node Biopsy, but I would be super surprised with how thin your melanoma is if it would be done. Always better to ask and see what they say.
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- February 21, 2014 at 1:10 pm
This is not a death sentence! It states in the pathology report that the thickness of the melanoma is .4mm. Anything under 1 mm with a low miotic rate that isn't ulcerated is considered stage 1a. The basic thinking is the thinner the melanoma the better the outcome.
I went to the Sloan Kettering Melanoma Clinic which is in Long Island, which might not be too far from you depending where in Jersey you are. They were really great. I would definitely ask about a Sentinal Node Biopsy, but I would be super surprised with how thin your melanoma is if it would be done. Always better to ask and see what they say.
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- February 21, 2014 at 1:10 pm
This is not a death sentence! It states in the pathology report that the thickness of the melanoma is .4mm. Anything under 1 mm with a low miotic rate that isn't ulcerated is considered stage 1a. The basic thinking is the thinner the melanoma the better the outcome.
I went to the Sloan Kettering Melanoma Clinic which is in Long Island, which might not be too far from you depending where in Jersey you are. They were really great. I would definitely ask about a Sentinal Node Biopsy, but I would be super surprised with how thin your melanoma is if it would be done. Always better to ask and see what they say.
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- February 21, 2014 at 1:15 pm
Lilyrose,
Although all melanoma is serious, generally melanoma's less than 1.0 thick is considered low risk. I'm going to restrain from giving any advice because I suspect Janner will chime in soon as she is outstanding for giving advice to folks in your situation. I might suggest you let us know your general location (North, South, Central NJ). I'm sure we have people on the forum that can give you suggestions for a dermatologist specializing in melanoma in your area. Hang in there. Like the first poster said, your prognosis is very good at this point. You did a great job in catching this early.
Brian
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- February 21, 2014 at 1:15 pm
Lilyrose,
Although all melanoma is serious, generally melanoma's less than 1.0 thick is considered low risk. I'm going to restrain from giving any advice because I suspect Janner will chime in soon as she is outstanding for giving advice to folks in your situation. I might suggest you let us know your general location (North, South, Central NJ). I'm sure we have people on the forum that can give you suggestions for a dermatologist specializing in melanoma in your area. Hang in there. Like the first poster said, your prognosis is very good at this point. You did a great job in catching this early.
Brian
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- February 21, 2014 at 1:15 pm
Lilyrose,
Although all melanoma is serious, generally melanoma's less than 1.0 thick is considered low risk. I'm going to restrain from giving any advice because I suspect Janner will chime in soon as she is outstanding for giving advice to folks in your situation. I might suggest you let us know your general location (North, South, Central NJ). I'm sure we have people on the forum that can give you suggestions for a dermatologist specializing in melanoma in your area. Hang in there. Like the first poster said, your prognosis is very good at this point. You did a great job in catching this early.
Brian
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- February 21, 2014 at 1:33 pm
I can't thank you all enough for taking time to give me info. I currently live in howell nj which is Monmouth county. I was thinking it would be worth the ride to go up to Sloan Kettering in basking ridge, I called and they gave me a consult date of 3/18/14.
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- February 21, 2014 at 1:33 pm
I can't thank you all enough for taking time to give me info. I currently live in howell nj which is Monmouth county. I was thinking it would be worth the ride to go up to Sloan Kettering in basking ridge, I called and they gave me a consult date of 3/18/14.
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- February 21, 2014 at 1:33 pm
I can't thank you all enough for taking time to give me info. I currently live in howell nj which is Monmouth county. I was thinking it would be worth the ride to go up to Sloan Kettering in basking ridge, I called and they gave me a consult date of 3/18/14.
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- February 21, 2014 at 2:19 pm
I used to live in Lakewood! Small world.
Since you live in central Jersey you have a number of other options open to you if things don't pan out for you in Basking Ridge. When you have something like melanoma you want to make sure you see a physician who looks at these things on a daily basis and specializes in it. I'm not 100% sure that Sloan's facility in Basking Ridge has one of their melanoma specialists practicing there.
Abramson Cancer Center has a melanoma clinic and they are in Phillie. Traffic-wise it's a LOT less stressful to go to Phillie than NYC. And since you're probably not far from Interstate 195, it's a piece of cake to get to Phillie.
There's also the Cancer Institute of NJ in New Brunswick that has a melanoma clinic. I think they're part of Robert Wood Johnson. Don't know much about them, though.
St. Luke's in Bethlehem, PA is also doable for you.
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- February 21, 2014 at 2:19 pm
I used to live in Lakewood! Small world.
Since you live in central Jersey you have a number of other options open to you if things don't pan out for you in Basking Ridge. When you have something like melanoma you want to make sure you see a physician who looks at these things on a daily basis and specializes in it. I'm not 100% sure that Sloan's facility in Basking Ridge has one of their melanoma specialists practicing there.
Abramson Cancer Center has a melanoma clinic and they are in Phillie. Traffic-wise it's a LOT less stressful to go to Phillie than NYC. And since you're probably not far from Interstate 195, it's a piece of cake to get to Phillie.
There's also the Cancer Institute of NJ in New Brunswick that has a melanoma clinic. I think they're part of Robert Wood Johnson. Don't know much about them, though.
St. Luke's in Bethlehem, PA is also doable for you.
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- February 21, 2014 at 2:19 pm
I used to live in Lakewood! Small world.
Since you live in central Jersey you have a number of other options open to you if things don't pan out for you in Basking Ridge. When you have something like melanoma you want to make sure you see a physician who looks at these things on a daily basis and specializes in it. I'm not 100% sure that Sloan's facility in Basking Ridge has one of their melanoma specialists practicing there.
Abramson Cancer Center has a melanoma clinic and they are in Phillie. Traffic-wise it's a LOT less stressful to go to Phillie than NYC. And since you're probably not far from Interstate 195, it's a piece of cake to get to Phillie.
There's also the Cancer Institute of NJ in New Brunswick that has a melanoma clinic. I think they're part of Robert Wood Johnson. Don't know much about them, though.
St. Luke's in Bethlehem, PA is also doable for you.
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- February 21, 2014 at 2:28 pm
Brian is right, Janner is our melanoma guru especially for early stage melanoma like yours is. Hopefully, she will chime in soon.
In the meanwhile, let me put things in context. The three most important details in a path report are: 1) Breslow depth (how deep the melanoma is growing into your skin), 2) mitotic index (how fast the cells are dividing), and 3) ulceration (whether the lesion has ruptured). Your Breslow depth of 0.4 mm is thin. Most doctors don't worry about it until a lesion is at least 0.76 or 1.0 mm. Some people are diagnosed with Breslow >4.0 mm and some even > 8.0 mm. So yours is thin, which is good. Your path report does not mention mitotic index so I assume that they didn't see any actively dividing cells under the microscope. That is also good. And your lesion is not ulcerated. Again, good.
It sounds like you had what you might call a "funny-looking mole" (non-cancerous dysplastic nevus) that was just starting to turn cancerous. You acted quickly and caught it early. You will probably now have a "wide local excision" (WLE) to make absolutely certain that they got it all and then regular follow-ups with a melanoma dermatologist for quite a while. You and your baby will both be fine.
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- February 21, 2014 at 2:28 pm
Brian is right, Janner is our melanoma guru especially for early stage melanoma like yours is. Hopefully, she will chime in soon.
In the meanwhile, let me put things in context. The three most important details in a path report are: 1) Breslow depth (how deep the melanoma is growing into your skin), 2) mitotic index (how fast the cells are dividing), and 3) ulceration (whether the lesion has ruptured). Your Breslow depth of 0.4 mm is thin. Most doctors don't worry about it until a lesion is at least 0.76 or 1.0 mm. Some people are diagnosed with Breslow >4.0 mm and some even > 8.0 mm. So yours is thin, which is good. Your path report does not mention mitotic index so I assume that they didn't see any actively dividing cells under the microscope. That is also good. And your lesion is not ulcerated. Again, good.
It sounds like you had what you might call a "funny-looking mole" (non-cancerous dysplastic nevus) that was just starting to turn cancerous. You acted quickly and caught it early. You will probably now have a "wide local excision" (WLE) to make absolutely certain that they got it all and then regular follow-ups with a melanoma dermatologist for quite a while. You and your baby will both be fine.
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- February 21, 2014 at 2:28 pm
Brian is right, Janner is our melanoma guru especially for early stage melanoma like yours is. Hopefully, she will chime in soon.
In the meanwhile, let me put things in context. The three most important details in a path report are: 1) Breslow depth (how deep the melanoma is growing into your skin), 2) mitotic index (how fast the cells are dividing), and 3) ulceration (whether the lesion has ruptured). Your Breslow depth of 0.4 mm is thin. Most doctors don't worry about it until a lesion is at least 0.76 or 1.0 mm. Some people are diagnosed with Breslow >4.0 mm and some even > 8.0 mm. So yours is thin, which is good. Your path report does not mention mitotic index so I assume that they didn't see any actively dividing cells under the microscope. That is also good. And your lesion is not ulcerated. Again, good.
It sounds like you had what you might call a "funny-looking mole" (non-cancerous dysplastic nevus) that was just starting to turn cancerous. You acted quickly and caught it early. You will probably now have a "wide local excision" (WLE) to make absolutely certain that they got it all and then regular follow-ups with a melanoma dermatologist for quite a while. You and your baby will both be fine.
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- February 21, 2014 at 2:40 pm
" was just starting to turn cancerous"
I don't know that I agree with that, as this was invasive, not in situ. Melanoma with any depth, such as 0.4mm, means it was invasive and penetrated the epidermis into the dermis. Although thin, which is good, still invasive. Severly atypical or in situ I might agree is "just starting to turn cancerous"
The other thing you might ask about if you don't see mentioned in pathology is regression.
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- February 21, 2014 at 2:40 pm
" was just starting to turn cancerous"
I don't know that I agree with that, as this was invasive, not in situ. Melanoma with any depth, such as 0.4mm, means it was invasive and penetrated the epidermis into the dermis. Although thin, which is good, still invasive. Severly atypical or in situ I might agree is "just starting to turn cancerous"
The other thing you might ask about if you don't see mentioned in pathology is regression.
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- February 21, 2014 at 2:40 pm
" was just starting to turn cancerous"
I don't know that I agree with that, as this was invasive, not in situ. Melanoma with any depth, such as 0.4mm, means it was invasive and penetrated the epidermis into the dermis. Although thin, which is good, still invasive. Severly atypical or in situ I might agree is "just starting to turn cancerous"
The other thing you might ask about if you don't see mentioned in pathology is regression.
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- February 21, 2014 at 7:53 pm
To be accurate Breslow refers to the thickness of the tumor and the depth (or penetration into the skin) is the Clark level. In your instance both are at the lower (good) end of the scales. In spite of the early character of this melanoma I would not take it lightly. The descripton of the margins needs to be discussed. Sometimes a reexcision is done to ensure adequate margins.Thin melanomas in young individuals can sometimes be more aggressive. All the more reason to seek out a melanoma specialist. Martin Mihm is one of the best dermatopathologists in the world. You have started at a good place.
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- February 21, 2014 at 10:06 pm
There has been debate in the literature about whether to do an SNB in thin melanomas (less than 0.76-1mm). However, some data have shown a positive rate as high as 5% in young patients with thin lesions. Attempts have been made to find distinquishing characteristics. The presence of a mitotic rate greater than 0, a vertical growth phase, clark level 4, male sex, and age less than forty years may all be factors. Below are two relevant references which support this counter intuitive phenomena.
Incidence of Sentinel Node Metastasis in Patients With Thin Primary Melanoma (#1 mm) With Vertical Growth Phase
Abstract
Background: Patients with thin primary melanomas (#1 mm) generally have an excellent prognosis. However, the presence of a vertical growth phase (VGP) adversely impacts the survival rate. We report on the rate of occurrence of nodal metastasis in patients with thin primary melanomas with a VGP who are offered sentinel lymph node (SLN) biopsy.
Methods: Among 235 patients with clinically localized cutaneous melanomas who underwent successful SLN biopsy, 71 had lesions 1 mm or smaller with a VGP. The SLN was localized by using blue dye and a radiotracer. If negative for tumor by using hematoxylin and eosin staining, the SLN was further examined by immunohistochemistry.
Results: The rate of occurrence of SLN metastasis was 15.2% in patients with melanomas deeper than 1 mm and 5.6% in patients with thin melanomas. Three patients with thin melanomas and a positive SLN had low-risk lesions, based on a highly accurate six-variable multivariate logistic regression model for predicting 8-year survival in stage I/II melanomas. The fourth patient had a low- to intermediate-risk lesion based on this model. At the time of the lymphadenectomy, one patient had two additional nodes with metastasis.
Conclusions: VGP in a melanoma 1 mm or smaller seems to be a risk factor for nodal metastasis. The risk of nodal disease may not be accurately predicted by the use of a multivariate logistic regression model that incorporates thickness, mitotic rate, regression, tumor-infiltrating lymphocytes, sex, and anatomical site. Patients with thin lesions having VGP should be evaluated for SLN biopsy and trials of adjuvant therapy when stage III disease is found.
Presented at the 52nd Annual Meeting of the Society of Surgical Oncology, Orlando, Florida, March 4–7, 1999.___________________________________________________________________________________Ann Surg Oncol. 2014 Feb 15. [Epub ahead of print]Age as a Predictor of Sentinel Node Metastasis among Patients with Localized Melanoma: An Inverse Correlation of Melanoma Mortality and Incidence of Sentinel Node Metastasis Among Young and Old Patients.
Balch CM1, Thompson JF, Gershenwald JE, Soong SJ, Ding S, McMasters KM, Coit DG, Eggermont AM, Gimotty PA, Johnson TM, Kirkwood JM, Leong SP, Ross MI, Byrd DR, Cochran AJ, Mihm MC Jr, Morton DL, Atkins MB, Flaherty KT, Sondak VK.Abstract
PURPOSE:
We have previously reported that older patients with clinical stage I and II primary cutaneous. Melanoma had lower survival rates compared to younger patients. We postulated that the incidence of nodal metastasis would therefore be higher among older melanoma patients.
METHODS:
The expanded American Joint Committee on Cancer melanoma staging database contains a cohort of 7,756 melanoma patients who presented without clinical evidence of regional lymph node or distant metastasis and who underwent a sentinel node biopsy procedure as a component of their staging assessment.
RESULTS:
Although older patients had primary melanoma features associated with more aggressive biology, we paradoxically observed a significant decrease in the incidence of sentinel node metastasis as patient age increased. Overall, the highest incidence of sentinel node metastasis was 25.8 % in patients under 20 years of age, compared to 15.5 % in patients 80 years and older (p < 0.001). In contrast, 5-year mortality rates for clinical stage II patients ranged from a low of 20 % for those 20-40 years of age up to 38 % for those over 70 years of age. Patient age was an independent predictor of sentinel node metastasis in a multifactorial analysis (p < 0.001).
CONCLUSIONS:
Patients with clinical stage I and II melanoma under 20 years of age had a higher incidence of sentinel lymph node metastasis but, paradoxically, a more favorable survival outcome compared to all other age groups. In contrast, patients >70 years had the most aggressive primary melanoma features and a higher mortality rate compared to all other age groups but a lower incidence of sentinel lymph node metastasis.
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- February 21, 2014 at 10:58 pm
I think you will find the statistics in this reference.
Arch Surg. Author manuscript; available in PMC 2011 February 1.Published in final edited form as:PMCID: PMC2880665NIHMSID: NIHMS192811Predictors of Occult Nodal Metastasis in Patients with Thin Melanoma
Mark B. Faries, M.D., Leslie A. Wanek, PhD, David Elashoff, PhD, Byron E. Wright, M.D., and Donald L. Morton, M.D.Abstract
Background and Hypothesis
Although thin primary lesions are largely responsible for the rapid increase in melanoma incidence, making identification of appropriate candidates for nodal staging in this group critically important. We hypothesized that common clinical parameters may accurately estimate the risk of nodal metastasis after wide excision and determine the need for sentinel node (SN) biopsy.
Design and Setting
Review of prospectively acquired data in the large melanoma database at a tertiary referral center
Patients and Methods
We identified patients seen within 6 months of diagnosis of thin (<1 mm) melanoma and treated by wide excision alone. We examined the rate of regional nodal recurrence and the impact of clinical/demographic variables by univariate and multivariate analyses.
Results
The overall nodal recurrence rate was 2.9%; median time to recurrence was 38.3 months. Univariate analysis of 1732 patients identified male sex (p<0.001), increased Breslow thickness (p<0.001), and increased Clark level (p<0.001) as significant for nodal recurrence. Multivariate analysis identified male sex (p=0.0005, HR 3.5), younger age (p=0.0019, HR 0.45), and increased Breslow thickness (categorical, p<0.001, HR 2.47) as significant. Clark was no longer significant (p=0.6). Breslow thickness, age and sex were used to develop a scoring system and nomogram for the risk of nodal involvement: predictions ranged from 0.1% in the lowest risk group to 17.4% in the highest risk group.
Conclusion
Many patients with thin melanoma will have nodal recurrence after wide excision alone. Three simple clinical parameters may be used to estimate recurrence risk and select patients for SN biopsy.
It includes this figure:
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- February 21, 2014 at 11:00 pm
Sorry the fiqure would not post. If you access the article it is figure 1a.
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- February 21, 2014 at 11:00 pm
Sorry the fiqure would not post. If you access the article it is figure 1a.
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- February 21, 2014 at 11:00 pm
Sorry the fiqure would not post. If you access the article it is figure 1a.
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- February 21, 2014 at 10:58 pm
I think you will find the statistics in this reference.
Arch Surg. Author manuscript; available in PMC 2011 February 1.Published in final edited form as:PMCID: PMC2880665NIHMSID: NIHMS192811Predictors of Occult Nodal Metastasis in Patients with Thin Melanoma
Mark B. Faries, M.D., Leslie A. Wanek, PhD, David Elashoff, PhD, Byron E. Wright, M.D., and Donald L. Morton, M.D.Abstract
Background and Hypothesis
Although thin primary lesions are largely responsible for the rapid increase in melanoma incidence, making identification of appropriate candidates for nodal staging in this group critically important. We hypothesized that common clinical parameters may accurately estimate the risk of nodal metastasis after wide excision and determine the need for sentinel node (SN) biopsy.
Design and Setting
Review of prospectively acquired data in the large melanoma database at a tertiary referral center
Patients and Methods
We identified patients seen within 6 months of diagnosis of thin (<1 mm) melanoma and treated by wide excision alone. We examined the rate of regional nodal recurrence and the impact of clinical/demographic variables by univariate and multivariate analyses.
Results
The overall nodal recurrence rate was 2.9%; median time to recurrence was 38.3 months. Univariate analysis of 1732 patients identified male sex (p<0.001), increased Breslow thickness (p<0.001), and increased Clark level (p<0.001) as significant for nodal recurrence. Multivariate analysis identified male sex (p=0.0005, HR 3.5), younger age (p=0.0019, HR 0.45), and increased Breslow thickness (categorical, p<0.001, HR 2.47) as significant. Clark was no longer significant (p=0.6). Breslow thickness, age and sex were used to develop a scoring system and nomogram for the risk of nodal involvement: predictions ranged from 0.1% in the lowest risk group to 17.4% in the highest risk group.
Conclusion
Many patients with thin melanoma will have nodal recurrence after wide excision alone. Three simple clinical parameters may be used to estimate recurrence risk and select patients for SN biopsy.
It includes this figure:
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- February 21, 2014 at 10:58 pm
I think you will find the statistics in this reference.
Arch Surg. Author manuscript; available in PMC 2011 February 1.Published in final edited form as:PMCID: PMC2880665NIHMSID: NIHMS192811Predictors of Occult Nodal Metastasis in Patients with Thin Melanoma
Mark B. Faries, M.D., Leslie A. Wanek, PhD, David Elashoff, PhD, Byron E. Wright, M.D., and Donald L. Morton, M.D.Abstract
Background and Hypothesis
Although thin primary lesions are largely responsible for the rapid increase in melanoma incidence, making identification of appropriate candidates for nodal staging in this group critically important. We hypothesized that common clinical parameters may accurately estimate the risk of nodal metastasis after wide excision and determine the need for sentinel node (SN) biopsy.
Design and Setting
Review of prospectively acquired data in the large melanoma database at a tertiary referral center
Patients and Methods
We identified patients seen within 6 months of diagnosis of thin (<1 mm) melanoma and treated by wide excision alone. We examined the rate of regional nodal recurrence and the impact of clinical/demographic variables by univariate and multivariate analyses.
Results
The overall nodal recurrence rate was 2.9%; median time to recurrence was 38.3 months. Univariate analysis of 1732 patients identified male sex (p<0.001), increased Breslow thickness (p<0.001), and increased Clark level (p<0.001) as significant for nodal recurrence. Multivariate analysis identified male sex (p=0.0005, HR 3.5), younger age (p=0.0019, HR 0.45), and increased Breslow thickness (categorical, p<0.001, HR 2.47) as significant. Clark was no longer significant (p=0.6). Breslow thickness, age and sex were used to develop a scoring system and nomogram for the risk of nodal involvement: predictions ranged from 0.1% in the lowest risk group to 17.4% in the highest risk group.
Conclusion
Many patients with thin melanoma will have nodal recurrence after wide excision alone. Three simple clinical parameters may be used to estimate recurrence risk and select patients for SN biopsy.
It includes this figure:
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- February 21, 2014 at 10:06 pm
There has been debate in the literature about whether to do an SNB in thin melanomas (less than 0.76-1mm). However, some data have shown a positive rate as high as 5% in young patients with thin lesions. Attempts have been made to find distinquishing characteristics. The presence of a mitotic rate greater than 0, a vertical growth phase, clark level 4, male sex, and age less than forty years may all be factors. Below are two relevant references which support this counter intuitive phenomena.
Incidence of Sentinel Node Metastasis in Patients With Thin Primary Melanoma (#1 mm) With Vertical Growth Phase
Abstract
Background: Patients with thin primary melanomas (#1 mm) generally have an excellent prognosis. However, the presence of a vertical growth phase (VGP) adversely impacts the survival rate. We report on the rate of occurrence of nodal metastasis in patients with thin primary melanomas with a VGP who are offered sentinel lymph node (SLN) biopsy.
Methods: Among 235 patients with clinically localized cutaneous melanomas who underwent successful SLN biopsy, 71 had lesions 1 mm or smaller with a VGP. The SLN was localized by using blue dye and a radiotracer. If negative for tumor by using hematoxylin and eosin staining, the SLN was further examined by immunohistochemistry.
Results: The rate of occurrence of SLN metastasis was 15.2% in patients with melanomas deeper than 1 mm and 5.6% in patients with thin melanomas. Three patients with thin melanomas and a positive SLN had low-risk lesions, based on a highly accurate six-variable multivariate logistic regression model for predicting 8-year survival in stage I/II melanomas. The fourth patient had a low- to intermediate-risk lesion based on this model. At the time of the lymphadenectomy, one patient had two additional nodes with metastasis.
Conclusions: VGP in a melanoma 1 mm or smaller seems to be a risk factor for nodal metastasis. The risk of nodal disease may not be accurately predicted by the use of a multivariate logistic regression model that incorporates thickness, mitotic rate, regression, tumor-infiltrating lymphocytes, sex, and anatomical site. Patients with thin lesions having VGP should be evaluated for SLN biopsy and trials of adjuvant therapy when stage III disease is found.
Presented at the 52nd Annual Meeting of the Society of Surgical Oncology, Orlando, Florida, March 4–7, 1999.___________________________________________________________________________________Ann Surg Oncol. 2014 Feb 15. [Epub ahead of print]Age as a Predictor of Sentinel Node Metastasis among Patients with Localized Melanoma: An Inverse Correlation of Melanoma Mortality and Incidence of Sentinel Node Metastasis Among Young and Old Patients.
Balch CM1, Thompson JF, Gershenwald JE, Soong SJ, Ding S, McMasters KM, Coit DG, Eggermont AM, Gimotty PA, Johnson TM, Kirkwood JM, Leong SP, Ross MI, Byrd DR, Cochran AJ, Mihm MC Jr, Morton DL, Atkins MB, Flaherty KT, Sondak VK.Abstract
PURPOSE:
We have previously reported that older patients with clinical stage I and II primary cutaneous. Melanoma had lower survival rates compared to younger patients. We postulated that the incidence of nodal metastasis would therefore be higher among older melanoma patients.
METHODS:
The expanded American Joint Committee on Cancer melanoma staging database contains a cohort of 7,756 melanoma patients who presented without clinical evidence of regional lymph node or distant metastasis and who underwent a sentinel node biopsy procedure as a component of their staging assessment.
RESULTS:
Although older patients had primary melanoma features associated with more aggressive biology, we paradoxically observed a significant decrease in the incidence of sentinel node metastasis as patient age increased. Overall, the highest incidence of sentinel node metastasis was 25.8 % in patients under 20 years of age, compared to 15.5 % in patients 80 years and older (p < 0.001). In contrast, 5-year mortality rates for clinical stage II patients ranged from a low of 20 % for those 20-40 years of age up to 38 % for those over 70 years of age. Patient age was an independent predictor of sentinel node metastasis in a multifactorial analysis (p < 0.001).
CONCLUSIONS:
Patients with clinical stage I and II melanoma under 20 years of age had a higher incidence of sentinel lymph node metastasis but, paradoxically, a more favorable survival outcome compared to all other age groups. In contrast, patients >70 years had the most aggressive primary melanoma features and a higher mortality rate compared to all other age groups but a lower incidence of sentinel lymph node metastasis.
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- February 21, 2014 at 10:06 pm
There has been debate in the literature about whether to do an SNB in thin melanomas (less than 0.76-1mm). However, some data have shown a positive rate as high as 5% in young patients with thin lesions. Attempts have been made to find distinquishing characteristics. The presence of a mitotic rate greater than 0, a vertical growth phase, clark level 4, male sex, and age less than forty years may all be factors. Below are two relevant references which support this counter intuitive phenomena.
Incidence of Sentinel Node Metastasis in Patients With Thin Primary Melanoma (#1 mm) With Vertical Growth Phase
Abstract
Background: Patients with thin primary melanomas (#1 mm) generally have an excellent prognosis. However, the presence of a vertical growth phase (VGP) adversely impacts the survival rate. We report on the rate of occurrence of nodal metastasis in patients with thin primary melanomas with a VGP who are offered sentinel lymph node (SLN) biopsy.
Methods: Among 235 patients with clinically localized cutaneous melanomas who underwent successful SLN biopsy, 71 had lesions 1 mm or smaller with a VGP. The SLN was localized by using blue dye and a radiotracer. If negative for tumor by using hematoxylin and eosin staining, the SLN was further examined by immunohistochemistry.
Results: The rate of occurrence of SLN metastasis was 15.2% in patients with melanomas deeper than 1 mm and 5.6% in patients with thin melanomas. Three patients with thin melanomas and a positive SLN had low-risk lesions, based on a highly accurate six-variable multivariate logistic regression model for predicting 8-year survival in stage I/II melanomas. The fourth patient had a low- to intermediate-risk lesion based on this model. At the time of the lymphadenectomy, one patient had two additional nodes with metastasis.
Conclusions: VGP in a melanoma 1 mm or smaller seems to be a risk factor for nodal metastasis. The risk of nodal disease may not be accurately predicted by the use of a multivariate logistic regression model that incorporates thickness, mitotic rate, regression, tumor-infiltrating lymphocytes, sex, and anatomical site. Patients with thin lesions having VGP should be evaluated for SLN biopsy and trials of adjuvant therapy when stage III disease is found.
Presented at the 52nd Annual Meeting of the Society of Surgical Oncology, Orlando, Florida, March 4–7, 1999.___________________________________________________________________________________Ann Surg Oncol. 2014 Feb 15. [Epub ahead of print]Age as a Predictor of Sentinel Node Metastasis among Patients with Localized Melanoma: An Inverse Correlation of Melanoma Mortality and Incidence of Sentinel Node Metastasis Among Young and Old Patients.
Balch CM1, Thompson JF, Gershenwald JE, Soong SJ, Ding S, McMasters KM, Coit DG, Eggermont AM, Gimotty PA, Johnson TM, Kirkwood JM, Leong SP, Ross MI, Byrd DR, Cochran AJ, Mihm MC Jr, Morton DL, Atkins MB, Flaherty KT, Sondak VK.Abstract
PURPOSE:
We have previously reported that older patients with clinical stage I and II primary cutaneous. Melanoma had lower survival rates compared to younger patients. We postulated that the incidence of nodal metastasis would therefore be higher among older melanoma patients.
METHODS:
The expanded American Joint Committee on Cancer melanoma staging database contains a cohort of 7,756 melanoma patients who presented without clinical evidence of regional lymph node or distant metastasis and who underwent a sentinel node biopsy procedure as a component of their staging assessment.
RESULTS:
Although older patients had primary melanoma features associated with more aggressive biology, we paradoxically observed a significant decrease in the incidence of sentinel node metastasis as patient age increased. Overall, the highest incidence of sentinel node metastasis was 25.8 % in patients under 20 years of age, compared to 15.5 % in patients 80 years and older (p < 0.001). In contrast, 5-year mortality rates for clinical stage II patients ranged from a low of 20 % for those 20-40 years of age up to 38 % for those over 70 years of age. Patient age was an independent predictor of sentinel node metastasis in a multifactorial analysis (p < 0.001).
CONCLUSIONS:
Patients with clinical stage I and II melanoma under 20 years of age had a higher incidence of sentinel lymph node metastasis but, paradoxically, a more favorable survival outcome compared to all other age groups. In contrast, patients >70 years had the most aggressive primary melanoma features and a higher mortality rate compared to all other age groups but a lower incidence of sentinel lymph node metastasis.
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- February 21, 2014 at 7:53 pm
To be accurate Breslow refers to the thickness of the tumor and the depth (or penetration into the skin) is the Clark level. In your instance both are at the lower (good) end of the scales. In spite of the early character of this melanoma I would not take it lightly. The descripton of the margins needs to be discussed. Sometimes a reexcision is done to ensure adequate margins.Thin melanomas in young individuals can sometimes be more aggressive. All the more reason to seek out a melanoma specialist. Martin Mihm is one of the best dermatopathologists in the world. You have started at a good place.
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- February 21, 2014 at 7:53 pm
To be accurate Breslow refers to the thickness of the tumor and the depth (or penetration into the skin) is the Clark level. In your instance both are at the lower (good) end of the scales. In spite of the early character of this melanoma I would not take it lightly. The descripton of the margins needs to be discussed. Sometimes a reexcision is done to ensure adequate margins.Thin melanomas in young individuals can sometimes be more aggressive. All the more reason to seek out a melanoma specialist. Martin Mihm is one of the best dermatopathologists in the world. You have started at a good place.
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- February 21, 2014 at 7:48 pm
First, congratulations on your pregnancy.
Second, melanoma. The one thing you don't mention in your path report is if there is any mitosis or mitotic rate? Regardless, this is just going to be a little minor surgery. They will do some local anesthetic injections and remove a good chunk of skin around where the mole was. It can all be done in an office setting with local anesthesia. Once done, it shouldn't hinder anything to do with your pregnancy.
Now, the caveat. Since you are pregnant, moles often darken and change during pregnancy. You will want to be more vigilant watching for moles that change and see your derm often – just to stay on top of things. Your prognosis is very good with the first melanoma once it is surgically removed with larger margins. But you will need to stay on top of your other moles to make sure any other suspicious lesions are biopsied. Since pregnancy causes changes, this is very important.
I had a deeper melanoma (0.58mm) removed in 1992… and I'm still here and still stage I. Just for perspective. Take a deep breath and hang in there. Find a good dermatologist whose specialty extends beyond botox to skin cancer 🙂 and schedule an appointment. Ask any other questions you have here and we'll try to help.
Best wishes,
Janner
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- February 21, 2014 at 7:48 pm
First, congratulations on your pregnancy.
Second, melanoma. The one thing you don't mention in your path report is if there is any mitosis or mitotic rate? Regardless, this is just going to be a little minor surgery. They will do some local anesthetic injections and remove a good chunk of skin around where the mole was. It can all be done in an office setting with local anesthesia. Once done, it shouldn't hinder anything to do with your pregnancy.
Now, the caveat. Since you are pregnant, moles often darken and change during pregnancy. You will want to be more vigilant watching for moles that change and see your derm often – just to stay on top of things. Your prognosis is very good with the first melanoma once it is surgically removed with larger margins. But you will need to stay on top of your other moles to make sure any other suspicious lesions are biopsied. Since pregnancy causes changes, this is very important.
I had a deeper melanoma (0.58mm) removed in 1992… and I'm still here and still stage I. Just for perspective. Take a deep breath and hang in there. Find a good dermatologist whose specialty extends beyond botox to skin cancer 🙂 and schedule an appointment. Ask any other questions you have here and we'll try to help.
Best wishes,
Janner
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- February 21, 2014 at 7:48 pm
First, congratulations on your pregnancy.
Second, melanoma. The one thing you don't mention in your path report is if there is any mitosis or mitotic rate? Regardless, this is just going to be a little minor surgery. They will do some local anesthetic injections and remove a good chunk of skin around where the mole was. It can all be done in an office setting with local anesthesia. Once done, it shouldn't hinder anything to do with your pregnancy.
Now, the caveat. Since you are pregnant, moles often darken and change during pregnancy. You will want to be more vigilant watching for moles that change and see your derm often – just to stay on top of things. Your prognosis is very good with the first melanoma once it is surgically removed with larger margins. But you will need to stay on top of your other moles to make sure any other suspicious lesions are biopsied. Since pregnancy causes changes, this is very important.
I had a deeper melanoma (0.58mm) removed in 1992… and I'm still here and still stage I. Just for perspective. Take a deep breath and hang in there. Find a good dermatologist whose specialty extends beyond botox to skin cancer 🙂 and schedule an appointment. Ask any other questions you have here and we'll try to help.
Best wishes,
Janner
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- February 21, 2014 at 11:35 pm
Again I cannot thank everyone enough for all this nformation. I received the rest of the report today and if anyone can tell me anything else from this that would be great!
Comment:
this leision is definitely superficial spreading melanoma. It exhibits quie prominent pagetoid.and shows several fool (sp? It's blurry on fax) of microinvasion. There are no mitosis, ulceration or regression. The lesion arises in a background of a dysplastic nevus. The Mart-1 stain exhibits clearly the extent of the melanoma as well as the precursor legion. The Ki67 shows an increased epidermal and dermal signal. I recommend a re-excision with a 1.0 margin and careful follow up of patient.
ok so this was the rest of the pathology report I finally got. Does anyone know what a Mart-1 is and a Ki67?
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- February 21, 2014 at 11:35 pm
Again I cannot thank everyone enough for all this nformation. I received the rest of the report today and if anyone can tell me anything else from this that would be great!
Comment:
this leision is definitely superficial spreading melanoma. It exhibits quie prominent pagetoid.and shows several fool (sp? It's blurry on fax) of microinvasion. There are no mitosis, ulceration or regression. The lesion arises in a background of a dysplastic nevus. The Mart-1 stain exhibits clearly the extent of the melanoma as well as the precursor legion. The Ki67 shows an increased epidermal and dermal signal. I recommend a re-excision with a 1.0 margin and careful follow up of patient.
ok so this was the rest of the pathology report I finally got. Does anyone know what a Mart-1 is and a Ki67?
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- February 21, 2014 at 11:35 pm
Again I cannot thank everyone enough for all this nformation. I received the rest of the report today and if anyone can tell me anything else from this that would be great!
Comment:
this leision is definitely superficial spreading melanoma. It exhibits quie prominent pagetoid.and shows several fool (sp? It's blurry on fax) of microinvasion. There are no mitosis, ulceration or regression. The lesion arises in a background of a dysplastic nevus. The Mart-1 stain exhibits clearly the extent of the melanoma as well as the precursor legion. The Ki67 shows an increased epidermal and dermal signal. I recommend a re-excision with a 1.0 margin and careful follow up of patient.
ok so this was the rest of the pathology report I finally got. Does anyone know what a Mart-1 is and a Ki67?
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- February 21, 2014 at 11:58 pm
Lol no idea….this is all new to me. I have an appt next Friday at the cancer institute of nj ( they were able to get me on quicker then Sloan Kettering so I guess that's when I'll get me answers . Do you know what anything on there means?
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- February 21, 2014 at 11:58 pm
Lol no idea….this is all new to me. I have an appt next Friday at the cancer institute of nj ( they were able to get me on quicker then Sloan Kettering so I guess that's when I'll get me answers . Do you know what anything on there means?
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- February 21, 2014 at 11:58 pm
Lol no idea….this is all new to me. I have an appt next Friday at the cancer institute of nj ( they were able to get me on quicker then Sloan Kettering so I guess that's when I'll get me answers . Do you know what anything on there means?
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- February 22, 2014 at 12:23 am
Honestly, I have no idea, this s day 2 of dealing with this for me. I did get an appointment for next Friday at the cancer institute of nj ( they were able to get me in earlier then Sloan Kettering . I am hoping to get answers and info as I feel lost and being pregnant is definitely not helping any. Do you understand what anything else on the report means. Also, I have like 4 more odd moles and patches that I didn't show my primary ( she took off the cancerous one) and now I'm very worried about those as well.
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- February 22, 2014 at 12:23 am
Honestly, I have no idea, this s day 2 of dealing with this for me. I did get an appointment for next Friday at the cancer institute of nj ( they were able to get me in earlier then Sloan Kettering . I am hoping to get answers and info as I feel lost and being pregnant is definitely not helping any. Do you understand what anything else on the report means. Also, I have like 4 more odd moles and patches that I didn't show my primary ( she took off the cancerous one) and now I'm very worried about those as well.
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- February 22, 2014 at 12:23 am
Honestly, I have no idea, this s day 2 of dealing with this for me. I did get an appointment for next Friday at the cancer institute of nj ( they were able to get me in earlier then Sloan Kettering . I am hoping to get answers and info as I feel lost and being pregnant is definitely not helping any. Do you understand what anything else on the report means. Also, I have like 4 more odd moles and patches that I didn't show my primary ( she took off the cancerous one) and now I'm very worried about those as well.
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- February 22, 2014 at 12:32 am
Thanks again for all the helpful info
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- February 22, 2014 at 12:32 am
Thanks again for all the helpful info
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- February 22, 2014 at 12:32 am
Thanks again for all the helpful info
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- February 22, 2014 at 12:53 am
Mart1 is essentially a stain – a method to make identifying melanocytes easier. You are stage 1a. You need a derm. You need a wide local excision (WLE). You don't need blood work, an oncologist or anything else. You do need careful follow up because moles change during pregnancy. Most melanoma warriors only have one primary melanoma. Are your other moles similar to each other? You are really looking for the ugly duckling. Watch for CHANGE, that is the most important thing for your other moles. In the meantime, try not to stress this. (Not easy, I know). But this is truly a very low risk lesion and your prognosis is extremely good.
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- February 22, 2014 at 12:53 am
Mart1 is essentially a stain – a method to make identifying melanocytes easier. You are stage 1a. You need a derm. You need a wide local excision (WLE). You don't need blood work, an oncologist or anything else. You do need careful follow up because moles change during pregnancy. Most melanoma warriors only have one primary melanoma. Are your other moles similar to each other? You are really looking for the ugly duckling. Watch for CHANGE, that is the most important thing for your other moles. In the meantime, try not to stress this. (Not easy, I know). But this is truly a very low risk lesion and your prognosis is extremely good.
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- February 22, 2014 at 12:53 am
Mart1 is essentially a stain – a method to make identifying melanocytes easier. You are stage 1a. You need a derm. You need a wide local excision (WLE). You don't need blood work, an oncologist or anything else. You do need careful follow up because moles change during pregnancy. Most melanoma warriors only have one primary melanoma. Are your other moles similar to each other? You are really looking for the ugly duckling. Watch for CHANGE, that is the most important thing for your other moles. In the meantime, try not to stress this. (Not easy, I know). But this is truly a very low risk lesion and your prognosis is extremely good.
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- February 22, 2014 at 1:42 am
Ok one more question….. After I have more area removed am I then considered cancer free?? Like it's just gone and I'm healed? Trying hard to understand as we have never had this form in my family only ovarian which is very different. Should I not have made my focuses appt at the cancer center with the melanoma specialist… Would a derm be better?
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- February 22, 2014 at 1:42 am
Ok one more question….. After I have more area removed am I then considered cancer free?? Like it's just gone and I'm healed? Trying hard to understand as we have never had this form in my family only ovarian which is very different. Should I not have made my focuses appt at the cancer center with the melanoma specialist… Would a derm be better?
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- February 22, 2014 at 1:42 am
Ok one more question….. After I have more area removed am I then considered cancer free?? Like it's just gone and I'm healed? Trying hard to understand as we have never had this form in my family only ovarian which is very different. Should I not have made my focuses appt at the cancer center with the melanoma specialist… Would a derm be better?
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- February 22, 2014 at 2:31 am
Typo meant first appointment not focuses…lol
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- February 22, 2014 at 2:31 am
Typo meant first appointment not focuses…lol
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- February 22, 2014 at 2:31 am
Typo meant first appointment not focuses…lol
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- February 22, 2014 at 2:42 am
Many oncologist won't even see stage 1a patients. They treat active disease. I prefer a good derm to work with. One you have the surgery, you will be considered NED – no evidence of disease. There really is no "cure" for melanoma as it could come back many years later. But for stage 1a, the survival rates are in the high nineties – say 97% or thereabouts. It isn't 100% and there isn't a five year "I'm free". Your risk is extremely low, but not gone. Your risk of getting another primary is higher, about 8-9%. So the key is to be realistic about your odds. They are good. That is the main thing to live by. But you also need to be vigilant..my motto is "vigilant but not paranoid". This gets easier with time. I have a private yahoo email list for stage one individuals if you are interested. All have been in your shoes at one time. If you are interested, click on my name and go to my profile and email me.
janner
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- February 22, 2014 at 2:42 am
Many oncologist won't even see stage 1a patients. They treat active disease. I prefer a good derm to work with. One you have the surgery, you will be considered NED – no evidence of disease. There really is no "cure" for melanoma as it could come back many years later. But for stage 1a, the survival rates are in the high nineties – say 97% or thereabouts. It isn't 100% and there isn't a five year "I'm free". Your risk is extremely low, but not gone. Your risk of getting another primary is higher, about 8-9%. So the key is to be realistic about your odds. They are good. That is the main thing to live by. But you also need to be vigilant..my motto is "vigilant but not paranoid". This gets easier with time. I have a private yahoo email list for stage one individuals if you are interested. All have been in your shoes at one time. If you are interested, click on my name and go to my profile and email me.
janner
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- February 22, 2014 at 2:42 am
Many oncologist won't even see stage 1a patients. They treat active disease. I prefer a good derm to work with. One you have the surgery, you will be considered NED – no evidence of disease. There really is no "cure" for melanoma as it could come back many years later. But for stage 1a, the survival rates are in the high nineties – say 97% or thereabouts. It isn't 100% and there isn't a five year "I'm free". Your risk is extremely low, but not gone. Your risk of getting another primary is higher, about 8-9%. So the key is to be realistic about your odds. They are good. That is the main thing to live by. But you also need to be vigilant..my motto is "vigilant but not paranoid". This gets easier with time. I have a private yahoo email list for stage one individuals if you are interested. All have been in your shoes at one time. If you are interested, click on my name and go to my profile and email me.
janner
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- February 25, 2014 at 4:26 am
Survival curves always get better over time. So yes, there is a small percentage that have their melanoma return years later. There is no "you are cured after 5 years". Again, the curves improve over time. The further out you are, the better your odds. Nothing is a guarantee.
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- February 25, 2014 at 4:26 am
Survival curves always get better over time. So yes, there is a small percentage that have their melanoma return years later. There is no "you are cured after 5 years". Again, the curves improve over time. The further out you are, the better your odds. Nothing is a guarantee.
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- February 25, 2014 at 4:26 am
Survival curves always get better over time. So yes, there is a small percentage that have their melanoma return years later. There is no "you are cured after 5 years". Again, the curves improve over time. The further out you are, the better your odds. Nothing is a guarantee.
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Tagged: cutaneous melanoma
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