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Newly dignoseds confused about regression

Forums General Melanoma Community Newly dignoseds confused about regression

  • Post
    HU
    Participant

      Hi,

      I have  been diagnosed with melanoma on my upper back. Tumor is shalow (0.27mm), absent ulceration and no mitosis. Although I know that in terms of melanoma this is all pretty good news, I am really scared. My  pathology report says the tumor shows extensive regression, involving the papillary dermis. This has concerned my doctors enough that they are considering doing a lymph node biopsy. I can't find a lot of information regression and what this means of my prognosis. What I do find is mostly conflicting.Can anyone help?

      Thank you so much 

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    • Replies
        Janner
        Participant

          Regression is both good and bad – depending on the way you look at it.  Regression means your body recognized the lesion and attempted to destroy it.  Good.  But regression also means you don't know how deep the original primary was and staging can be compromised.  Bad.  Cells might have escaped the original lesion if the lesion was deep enough.   People can have an unknown primary and it is thought that the original lesion completely regressed but cells escaped and were transported elsewhere.  If my report listed extensive regression, I would definitely consider having a Sentinel Lymph Node Biopsy.  I'm not sure there is any clear concensus on long term prognosis – regression is not something included in the current staging so it's value has not been proven to affect staging as of now.  Part of that may relate to not being able to concisesly determine how much regression actually took place.

          Janner
          Participant

            Regression is both good and bad – depending on the way you look at it.  Regression means your body recognized the lesion and attempted to destroy it.  Good.  But regression also means you don't know how deep the original primary was and staging can be compromised.  Bad.  Cells might have escaped the original lesion if the lesion was deep enough.   People can have an unknown primary and it is thought that the original lesion completely regressed but cells escaped and were transported elsewhere.  If my report listed extensive regression, I would definitely consider having a Sentinel Lymph Node Biopsy.  I'm not sure there is any clear concensus on long term prognosis – regression is not something included in the current staging so it's value has not been proven to affect staging as of now.  Part of that may relate to not being able to concisesly determine how much regression actually took place.

            Janner
            Participant

              Regression is both good and bad – depending on the way you look at it.  Regression means your body recognized the lesion and attempted to destroy it.  Good.  But regression also means you don't know how deep the original primary was and staging can be compromised.  Bad.  Cells might have escaped the original lesion if the lesion was deep enough.   People can have an unknown primary and it is thought that the original lesion completely regressed but cells escaped and were transported elsewhere.  If my report listed extensive regression, I would definitely consider having a Sentinel Lymph Node Biopsy.  I'm not sure there is any clear concensus on long term prognosis – regression is not something included in the current staging so it's value has not been proven to affect staging as of now.  Part of that may relate to not being able to concisesly determine how much regression actually took place.

              HU
              Participant

                Thank you for your kind reply. I'm still really scared and worried about the implications of regression but guess there is no more to know.

                HU
                Participant

                  Thank you for your kind reply. I'm still really scared and worried about the implications of regression but guess there is no more to know.

                  HU
                  Participant

                    Thank you for your kind reply. I'm still really scared and worried about the implications of regression but guess there is no more to know.

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