pancreatic cancer and melanoma

what I wouldn't understand is if the melanoma is caused from over-sun-exposure, why would that impact the pancreas? 

what I wouldn't understand is if the melanoma is caused from over-sun-exposure, why would that impact the pancreas? 

what I wouldn't understand is if the melanoma is caused from over-sun-exposure, why would that impact the pancreas? 

There is a genetic mutation in a gene called CDKN2A and people with this mutation are at a very high risk for Melanoma. There is also an elevated risk of pancreatic cancer, although not nearly as elevated as the risk for melanoma. Those with this mutation are also much more susceptible to multiple melanoma primaries. The mutation is commonly found in instances of "familial" melanoma.

Here's what I read at MIF melanomaforum.org.:  In a paper published by the International Melanoma Genetics Consortium in 2002, 80 families were evaluated who had alterations to the P16 gene (also known as CDKN2A) The families were from the U.S., Europe and Australia.  Alterations in p16 are the main cause of inherited high susceptibility to melanoma identified so far. However in this study, only about 20% of families that have multiple members with melanoma have alterations in p16. The factors most influencing whether these people with the mutation P16 developed melanoma were the same as the population at large:  increasing age and residing in areas with a high incidence of melanoma (because of high UV.

Small connection between the two cancers is the P16.

Here's what I read at MIF melanomaforum.org.:  In a paper published by the International Melanoma Genetics Consortium in 2002, 80 families were evaluated who had alterations to the P16 gene (also known as CDKN2A) The families were from the U.S., Europe and Australia.  Alterations in p16 are the main cause of inherited high susceptibility to melanoma identified so far. However in this study, only about 20% of families that have multiple members with melanoma have alterations in p16. The factors most influencing whether these people with the mutation P16 developed melanoma were the same as the population at large:  increasing age and residing in areas with a high incidence of melanoma (because of high UV.

Small connection between the two cancers is the P16.

Hearing about President Carter's melanoma has brought back painful memories. Twenty-seven years ago this summer, my father had a melanoma on each elbow removed.  Sink grafts were needed on both arms.  This surgery was done by a plastic surgeon referred to us by a dermatologist.  My father was 80 years old and because he had congestive heart failure, a [different] surgeon decided not to remove the lymph nodes in his armpits.  I was told, "He is a poor surgical risk and beside it's [the melanoma] probably spread beyond this [lymph nodes in his arm pits].  By November the cancer [metastatic malignant melanoma] had spread to his kidneys.  The urologist tried to infarct the more infiltrated one but it did not take.  My Dad's PCP, primary care physician, was almost upset as we were.  "I do not know what we [the doctors] can do."  He said that he could feel the cancer spreading in Dad's liver, and other intestinal organs.  By January 1989, the MMM [metastatic malignant melanoma] had spread to his brain. He went into a coma.  Dad died January 18,1989, one month after his 81st birthday. 

It's amazing how much progress has been made in treating melanoma.  Two years ago I was diagnosed with malignant metastatic melanoma in my left parotid gland. I had a radical dissection of the parotid gland and the lymph glands on that side of my neck. I was eligible for a clinical trial.  After two infusions, treatment was stopped because I had a toxic reaction.   The primary melanoma [on my skin] was never found,  I have been NED since my surgery.  Some part of me is waiting for the other shoe to drop.  Now there is more ammunition to fight this. I may be somewhat afraid, but not too afraid to fight whatever happens.

Hearing about President Carter's melanoma has brought back painful memories. Twenty-seven years ago this summer, my father had a melanoma on each elbow removed.  Sink grafts were needed on both arms.  This surgery was done by a plastic surgeon referred to us by a dermatologist.  My father was 80 years old and because he had congestive heart failure, a [different] surgeon decided not to remove the lymph nodes in his armpits.  I was told, "He is a poor surgical risk and beside it's [the melanoma] probably spread beyond this [lymph nodes in his arm pits].  By November the cancer [metastatic malignant melanoma] had spread to his kidneys.  The urologist tried to infarct the more infiltrated one but it did not take.  My Dad's PCP, primary care physician, was almost upset as we were.  "I do not know what we [the doctors] can do."  He said that he could feel the cancer spreading in Dad's liver, and other intestinal organs.  By January 1989, the MMM [metastatic malignant melanoma] had spread to his brain. He went into a coma.  Dad died January 18,1989, one month after his 81st birthday. 

It's amazing how much progress has been made in treating melanoma.  Two years ago I was diagnosed with malignant metastatic melanoma in my left parotid gland. I had a radical dissection of the parotid gland and the lymph glands on that side of my neck. I was eligible for a clinical trial.  After two infusions, treatment was stopped because I had a toxic reaction.   The primary melanoma [on my skin] was never found,  I have been NED since my surgery.  Some part of me is waiting for the other shoe to drop.  Now there is more ammunition to fight this. I may be somewhat afraid, but not too afraid to fight whatever happens.

Hearing about President Carter's melanoma has brought back painful memories. Twenty-seven years ago this summer, my father had a melanoma on each elbow removed.  Sink grafts were needed on both arms.  This surgery was done by a plastic surgeon referred to us by a dermatologist.  My father was 80 years old and because he had congestive heart failure, a [different] surgeon decided not to remove the lymph nodes in his armpits.  I was told, "He is a poor surgical risk and beside it's [the melanoma] probably spread beyond this [lymph nodes in his arm pits].  By November the cancer [metastatic malignant melanoma] had spread to his kidneys.  The urologist tried to infarct the more infiltrated one but it did not take.  My Dad's PCP, primary care physician, was almost upset as we were.  "I do not know what we [the doctors] can do."  He said that he could feel the cancer spreading in Dad's liver, and other intestinal organs.  By January 1989, the MMM [metastatic malignant melanoma] had spread to his brain. He went into a coma.  Dad died January 18,1989, one month after his 81st birthday. 

It's amazing how much progress has been made in treating melanoma.  Two years ago I was diagnosed with malignant metastatic melanoma in my left parotid gland. I had a radical dissection of the parotid gland and the lymph glands on that side of my neck. I was eligible for a clinical trial.  After two infusions, treatment was stopped because I had a toxic reaction.   The primary melanoma [on my skin] was never found,  I have been NED since my surgery.  Some part of me is waiting for the other shoe to drop.  Now there is more ammunition to fight this. I may be somewhat afraid, but not too afraid to fight whatever happens.

Here's what I read at MIF melanomaforum.org.:  In a paper published by the International Melanoma Genetics Consortium in 2002, 80 families were evaluated who had alterations to the P16 gene (also known as CDKN2A) The families were from the U.S., Europe and Australia.  Alterations in p16 are the main cause of inherited high susceptibility to melanoma identified so far. However in this study, only about 20% of families that have multiple members with melanoma have alterations in p16. The factors most influencing whether these people with the mutation P16 developed melanoma were the same as the population at large:  increasing age and residing in areas with a high incidence of melanoma (because of high UV.

Small connection between the two cancers is the P16.

There is a genetic mutation in a gene called CDKN2A and people with this mutation are at a very high risk for Melanoma. There is also an elevated risk of pancreatic cancer, although not nearly as elevated as the risk for melanoma. Those with this mutation are also much more susceptible to multiple melanoma primaries. The mutation is commonly found in instances of "familial" melanoma.

There is a genetic mutation in a gene called CDKN2A and people with this mutation are at a very high risk for Melanoma. There is also an elevated risk of pancreatic cancer, although not nearly as elevated as the risk for melanoma. Those with this mutation are also much more susceptible to multiple melanoma primaries. The mutation is commonly found in instances of "familial" melanoma.