› Forums › General Melanoma Community › Pathology Report for mutation
- This topic has 9 replies, 3 voices, and was last updated 8 years, 10 months ago by
Cathy M.
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- June 27, 2016 at 12:07 pm
Can someone help me understand what this means? No mutuations or BRAF?
ONSIGHT NGS BRAF SEQUENCING REPORT:
NO MUTATIONS IDENTIFIED.
THIS WAS A NORMAL SEQUENCING STUDY IN WHICH NO DISEASE ASSOCIATIED MUTATIONS OR VARIENTS OF UNCLEAR SIGNIFICANCE WERE IDENTIFIED IN THE TESTED SPECIMEN WITH BRAF (EXONS 11, 15) INCLUSIVE OF V600
CLINICAL AND PATHOLOGIC CORRELATION IS REQUERED TO INTERPRET THESE FINDINGS:
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- June 27, 2016 at 12:30 pm
You don't have the BRAF mutation that would let you use BRAF targeted drugs.
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- July 14, 2016 at 3:03 am
As stated above you don't have a BRAF mutation that would allow you, by insurance standards, to take FDA approved drugs for patient's with the BRAF mutation. For example, go to FDA web and look up Yervoy, Mekinist, Keytruda, etc. When FDA approves drugs to fight melanoma and they say "with BRAF mutation" instead of just "for advanced melanoma" then it creates an insurance payment issue as insurance would consider it experimental and would not pay if you did not have the mutation specified. Also it looks like there were no other actionable mutations that have medications for treatment. Your medical oncologist should be able to discuss this with you and any options for clinical trials including help in suggesting clinical trials, even if they're not at the facility they work out of.
Start reading on reliable sites such as this one. Search clinical trials.gov. Read the drug manufacturers pages. There is soooo much info out there. Try to stick to reliable sources and then go in armed with questions for your oncologist. While we should trust our medical teams to take the best care of us possible, I firmly believe we are also our own best advocate. Learn all you can about this disease and good luck with your battle!!
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- July 14, 2016 at 3:03 am
As stated above you don't have a BRAF mutation that would allow you, by insurance standards, to take FDA approved drugs for patient's with the BRAF mutation. For example, go to FDA web and look up Yervoy, Mekinist, Keytruda, etc. When FDA approves drugs to fight melanoma and they say "with BRAF mutation" instead of just "for advanced melanoma" then it creates an insurance payment issue as insurance would consider it experimental and would not pay if you did not have the mutation specified. Also it looks like there were no other actionable mutations that have medications for treatment. Your medical oncologist should be able to discuss this with you and any options for clinical trials including help in suggesting clinical trials, even if they're not at the facility they work out of.
Start reading on reliable sites such as this one. Search clinical trials.gov. Read the drug manufacturers pages. There is soooo much info out there. Try to stick to reliable sources and then go in armed with questions for your oncologist. While we should trust our medical teams to take the best care of us possible, I firmly believe we are also our own best advocate. Learn all you can about this disease and good luck with your battle!!
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- July 14, 2016 at 3:03 am
As stated above you don't have a BRAF mutation that would allow you, by insurance standards, to take FDA approved drugs for patient's with the BRAF mutation. For example, go to FDA web and look up Yervoy, Mekinist, Keytruda, etc. When FDA approves drugs to fight melanoma and they say "with BRAF mutation" instead of just "for advanced melanoma" then it creates an insurance payment issue as insurance would consider it experimental and would not pay if you did not have the mutation specified. Also it looks like there were no other actionable mutations that have medications for treatment. Your medical oncologist should be able to discuss this with you and any options for clinical trials including help in suggesting clinical trials, even if they're not at the facility they work out of.
Start reading on reliable sites such as this one. Search clinical trials.gov. Read the drug manufacturers pages. There is soooo much info out there. Try to stick to reliable sources and then go in armed with questions for your oncologist. While we should trust our medical teams to take the best care of us possible, I firmly believe we are also our own best advocate. Learn all you can about this disease and good luck with your battle!!
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