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Pd-1 article form March on stopping treatment and how long patients remain disease free
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Pd-1 article form March on stopping treatment and how long patients remain disease free

› Forums › General Melanoma Community › Pd-1 article form March on stopping treatment and how long patients remain disease free

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      • April 4, 2019 at 4:16 pm
      TexMelanomex
      Participant

        Very interesting Ed, thanks for posting this. As I come to the end of my 2 year Pembro cycle this September…gives me some things to think about.

          • April 4, 2019 at 7:38 pm
          ed williams
          Participant

            I wish more articles like this one would get published, there has to be thousands of patients around the world that have been on Nivo or Pembro for at least 3 years now!!! Knowledge is power and 185 patients is only the tip of the iceberg when it comes to survival data!!! Glad to see that you are doing great!!!!

            • April 5, 2019 at 11:16 am
            SOLE
            Participant

              And I can’t help but think that the “recent” discoveries about microbiome involvment definitely has to be at play here not only in the CR group but in the PD one. Hence the difference also between the original trial 86% and real life 78%. My gut feeling!

              • April 5, 2019 at 1:55 pm
              ed williams
              Participant

                Nice use of " Gut feeling", my first thought was more like good data to support stopping if you are a complete responder (CR) but not so grate #'s for partial responders or stable disease folk!!! But with all early data, we need to wait for a bigger sample size!!! I have been sitting on the fence for some time about stopping and this data didn't help make me feel confident that if I stop and then progress and then get Nivo a second time that it will work!!! Speaking about your shitty topic of gut microbiome, did you read about what they found in these early result about using probiotics??? It seems that all those arm chair quarterback's had it wrong, using probiotics actual mess up a healthy gut microbiome!!! I know it is still early days in the research about what role the gut has to play in immunotherapy success, my hope is that eating a normal healthy diet will be the findings!!!

                • April 5, 2019 at 3:33 pm
                lkb
                Participant

                  I share that hope, Ed, and stopped taking a probiotic (though it was recommended by a nutritionist at a cancer center before the latest reports came out).

                  Lisa

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