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Phase II Study of Glembatumumab Vedotin… any insights or experiences?
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Phase II Study of Glembatumumab Vedotin… any insights or experiences?

› Forums › General Melanoma Community › Phase II Study of Glembatumumab Vedotin… any insights or experiences?

  • Post
    • December 6, 2016 at 11:44 pm
    BeckSTAR
    Participant

      Hello, I am new to this site.  My father was diagnosed with stage IV melanoma, summer of 2015.  (inital spots removed from skin on and off years ago, big one was from neck that they think must have spread even with removal of lymph with clear biopsy… despite routine check ups the metastasis was caught very late).  Summer 2015 showed a large tumor in liver and small spots in lung and gluteal areas.  He did well on Pembro, lasted almost 1.5years (until a couple weeks ago) without any resistance.  All spots disappeared except a "shell" of the liver tumor, which is now growing again.

      Now he is about to start Glembatumumab Vedotin next week after all the biopsy/scans/testings are completed for the study.  Anyone currently on this study or have experience with it?  Things to expect, look out for?  I am a nurse myself, but all this is pretty new to me.  I take care of the little humans (peds). 

      My father is 67, but in shape/active… walks/jogs every morning and head captain/manager of a small marina. 

      Thanks in advance,

      A concerned daughter heart

    Viewing 11 reply threads
    • Replies
        • December 7, 2016 at 6:04 am
        Patina
        Participant

          Can they do stereotactic body radiation therapy with keytruda or another immunotherapy followed shortly after? – Hoping for an abscopal effect.

            • December 8, 2016 at 3:28 am
            BeckSTAR
            Participant

              I haven't heard any talk about radiation at this point.  They may include another medicine/immuno with the Glem Ved but I am unsure what that is or how that is decided.  Since it is all a clinical trial I think he has to follow the constants that they need to keep.  So right now it is Glem Ved on it's own or Glem Ved + another med.

              • December 8, 2016 at 3:28 am
              BeckSTAR
              Participant

                I haven't heard any talk about radiation at this point.  They may include another medicine/immuno with the Glem Ved but I am unsure what that is or how that is decided.  Since it is all a clinical trial I think he has to follow the constants that they need to keep.  So right now it is Glem Ved on it's own or Glem Ved + another med.

                • December 8, 2016 at 4:37 am
                BeckSTAR
                Participant

                  other med it may be in combination with is varlilumab.

                  He is BRAF negative from what I read up on his biopsy from last year.

                  • December 8, 2016 at 4:37 am
                  BeckSTAR
                  Participant

                    other med it may be in combination with is varlilumab.

                    He is BRAF negative from what I read up on his biopsy from last year.

                    • December 8, 2016 at 4:37 am
                    BeckSTAR
                    Participant

                      other med it may be in combination with is varlilumab.

                      He is BRAF negative from what I read up on his biopsy from last year.

                      • December 8, 2016 at 3:28 am
                      BeckSTAR
                      Participant

                        I haven't heard any talk about radiation at this point.  They may include another medicine/immuno with the Glem Ved but I am unsure what that is or how that is decided.  Since it is all a clinical trial I think he has to follow the constants that they need to keep.  So right now it is Glem Ved on it's own or Glem Ved + another med.

                      • December 7, 2016 at 6:04 am
                      Patina
                      Participant

                        Can they do stereotactic body radiation therapy with keytruda or another immunotherapy followed shortly after? – Hoping for an abscopal effect.

                        • December 7, 2016 at 6:04 am
                        Patina
                        Participant

                          Can they do stereotactic body radiation therapy with keytruda or another immunotherapy followed shortly after? – Hoping for an abscopal effect.

                          • December 7, 2016 at 8:05 pm
                          Jeanne321
                          Participant

                            Hi – I have been on this trial for a year and a half. Each scan has shown shrinkage and side effects, after decreasing the initial strength, are very tolerable. I'm in the same age range as your Dad. Good luck to him. 

                            • December 7, 2016 at 8:05 pm
                            Jeanne321
                            Participant

                              Hi – I have been on this trial for a year and a half. Each scan has shown shrinkage and side effects, after decreasing the initial strength, are very tolerable. I'm in the same age range as your Dad. Good luck to him. 

                                • December 8, 2016 at 3:32 am
                                BeckSTAR
                                Participant

                                  Wow, that is amazing!  Thank you for this reassurance, I am hoping that this works awhile for him also.  After reading a bit on the trial it mentioned that having a rash initially may be indicative of it working better/longer? Did you experience any rash?  We did receive some good news today that looks like they will start it on Monday, a few days earlier…fingers crossed!  Good luck to you also.

                                  • December 8, 2016 at 3:32 am
                                  BeckSTAR
                                  Participant

                                    Wow, that is amazing!  Thank you for this reassurance, I am hoping that this works awhile for him also.  After reading a bit on the trial it mentioned that having a rash initially may be indicative of it working better/longer? Did you experience any rash?  We did receive some good news today that looks like they will start it on Monday, a few days earlier…fingers crossed!  Good luck to you also.

                                    • December 8, 2016 at 10:27 pm
                                    Jeanne321
                                    Participant

                                      Yes, rash was severe initially which was one reason that the dose was lowered. Since then I get the rash on day 3 after infusion, it only lasts about 5 days and is managed with Sarna lotion or steroid cream. 

                                      • December 8, 2016 at 10:27 pm
                                      Jeanne321
                                      Participant

                                        Yes, rash was severe initially which was one reason that the dose was lowered. Since then I get the rash on day 3 after infusion, it only lasts about 5 days and is managed with Sarna lotion or steroid cream. 

                                        • December 8, 2016 at 10:27 pm
                                        Jeanne321
                                        Participant

                                          Yes, rash was severe initially which was one reason that the dose was lowered. Since then I get the rash on day 3 after infusion, it only lasts about 5 days and is managed with Sarna lotion or steroid cream. 

                                          • December 8, 2016 at 3:32 am
                                          BeckSTAR
                                          Participant

                                            Wow, that is amazing!  Thank you for this reassurance, I am hoping that this works awhile for him also.  After reading a bit on the trial it mentioned that having a rash initially may be indicative of it working better/longer? Did you experience any rash?  We did receive some good news today that looks like they will start it on Monday, a few days earlier…fingers crossed!  Good luck to you also.

                                          • December 7, 2016 at 8:05 pm
                                          Jeanne321
                                          Participant

                                            Hi – I have been on this trial for a year and a half. Each scan has shown shrinkage and side effects, after decreasing the initial strength, are very tolerable. I'm in the same age range as your Dad. Good luck to him. 

                                            • December 8, 2016 at 3:51 am
                                            ed williams
                                            Participant

                                              Hi Beckstar, where is your dad being treated? Also what did the oncologist say in regards to early results with the drug conjugate (glembatumumab)? Best wishes!!!Ed

                                              • December 8, 2016 at 3:51 am
                                              ed williams
                                              Participant

                                                Hi Beckstar, where is your dad being treated? Also what did the oncologist say in regards to early results with the drug conjugate (glembatumumab)? Best wishes!!!Ed

                                                  • December 8, 2016 at 11:02 pm
                                                  BeckSTAR
                                                  Participant

                                                    Under Forida Cancer Specialists and Research Institute in Naples, FL.  My parents just vagely said "it's like Pembro"…should shrink/stop progression and his symptoms/pain should relieve within a couple weeks of starting hopefully. I am not there and haven't been able to speak to the MD.  It's frustrating because I am so far away (in Cali) although I'm taking FMLA to go be there for a month so hopefully can be more involved. 

                                                    • December 8, 2016 at 11:02 pm
                                                    BeckSTAR
                                                    Participant

                                                      Under Forida Cancer Specialists and Research Institute in Naples, FL.  My parents just vagely said "it's like Pembro"…should shrink/stop progression and his symptoms/pain should relieve within a couple weeks of starting hopefully. I am not there and haven't been able to speak to the MD.  It's frustrating because I am so far away (in Cali) although I'm taking FMLA to go be there for a month so hopefully can be more involved. 

                                                      • December 8, 2016 at 11:02 pm
                                                      BeckSTAR
                                                      Participant

                                                        Under Forida Cancer Specialists and Research Institute in Naples, FL.  My parents just vagely said "it's like Pembro"…should shrink/stop progression and his symptoms/pain should relieve within a couple weeks of starting hopefully. I am not there and haven't been able to speak to the MD.  It's frustrating because I am so far away (in Cali) although I'm taking FMLA to go be there for a month so hopefully can be more involved. 

                                                      • December 8, 2016 at 3:51 am
                                                      ed williams
                                                      Participant

                                                        Hi Beckstar, where is your dad being treated? Also what did the oncologist say in regards to early results with the drug conjugate (glembatumumab)? Best wishes!!!Ed

                                                        • December 8, 2016 at 2:02 pm
                                                        Bubbles
                                                        Participant

                                                          Here is an older link to a blog post I created re some of the initial work done with these meds:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/10/another-antibody-drug-conjugate-for.html

                                                          I think progress has been made in some of the antibody-drug-conjugates.  But thought is might interest you to see some of the background.  I wish you and your dad well.  Celeste

                                                           

                                                          • December 8, 2016 at 2:02 pm
                                                          Bubbles
                                                          Participant

                                                            Here is an older link to a blog post I created re some of the initial work done with these meds:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/10/another-antibody-drug-conjugate-for.html

                                                            I think progress has been made in some of the antibody-drug-conjugates.  But thought is might interest you to see some of the background.  I wish you and your dad well.  Celeste

                                                             

                                                              • December 8, 2016 at 3:47 pm
                                                              ed williams
                                                              Participant

                                                                I was looking at some of the information on Glembatumumab from the home page of the drug company that makes it called Celldex. If you clink on the link then look under "Pipeline" or "Investors and Media- then choose Press Releases." you should find some pretty good explainations of the various trials and they even give data of earlier trials etc. It wasn't that long ago that I was listening to Dr. Omid Hamid of the Angeles Clinic talking about what was coming in the future and Drug Conjugates were one to the paths along with CD27 a stimulating pathway for t-cell production. The future has arrived, so happy that more and more options keep opening up. Best wishes!!!Ed http://www.celldex.com/index.html

                                                                • December 8, 2016 at 3:47 pm
                                                                ed williams
                                                                Participant

                                                                  I was looking at some of the information on Glembatumumab from the home page of the drug company that makes it called Celldex. If you clink on the link then look under "Pipeline" or "Investors and Media- then choose Press Releases." you should find some pretty good explainations of the various trials and they even give data of earlier trials etc. It wasn't that long ago that I was listening to Dr. Omid Hamid of the Angeles Clinic talking about what was coming in the future and Drug Conjugates were one to the paths along with CD27 a stimulating pathway for t-cell production. The future has arrived, so happy that more and more options keep opening up. Best wishes!!!Ed http://www.celldex.com/index.html

                                                                  • December 8, 2016 at 11:06 pm
                                                                  BeckSTAR
                                                                  Participant

                                                                    I read up a little on the website but will def look into the media stuff.  Thanks!  I'm a little anxious right now becuase now he's in the ER for some infectious concerns…. I hope this doesn't delay the study med too much.  At least they ruled out a clot, now thinking cellulitis.  The nurse in me is concerned it is more tumor though :/ 

                                                                    • December 8, 2016 at 11:06 pm
                                                                    BeckSTAR
                                                                    Participant

                                                                      I read up a little on the website but will def look into the media stuff.  Thanks!  I'm a little anxious right now becuase now he's in the ER for some infectious concerns…. I hope this doesn't delay the study med too much.  At least they ruled out a clot, now thinking cellulitis.  The nurse in me is concerned it is more tumor though :/ 

                                                                      • December 8, 2016 at 11:06 pm
                                                                      BeckSTAR
                                                                      Participant

                                                                        I read up a little on the website but will def look into the media stuff.  Thanks!  I'm a little anxious right now becuase now he's in the ER for some infectious concerns…. I hope this doesn't delay the study med too much.  At least they ruled out a clot, now thinking cellulitis.  The nurse in me is concerned it is more tumor though :/ 

                                                                        • December 8, 2016 at 3:47 pm
                                                                        ed williams
                                                                        Participant

                                                                          I was looking at some of the information on Glembatumumab from the home page of the drug company that makes it called Celldex. If you clink on the link then look under "Pipeline" or "Investors and Media- then choose Press Releases." you should find some pretty good explainations of the various trials and they even give data of earlier trials etc. It wasn't that long ago that I was listening to Dr. Omid Hamid of the Angeles Clinic talking about what was coming in the future and Drug Conjugates were one to the paths along with CD27 a stimulating pathway for t-cell production. The future has arrived, so happy that more and more options keep opening up. Best wishes!!!Ed http://www.celldex.com/index.html

                                                                          • December 8, 2016 at 11:03 pm
                                                                          BeckSTAR
                                                                          Participant

                                                                            Great! Haven't seen this info so thanks so much for sharing.

                                                                            • December 8, 2016 at 11:03 pm
                                                                            BeckSTAR
                                                                            Participant

                                                                              Great! Haven't seen this info so thanks so much for sharing.

                                                                              • December 8, 2016 at 11:03 pm
                                                                              BeckSTAR
                                                                              Participant

                                                                                Great! Haven't seen this info so thanks so much for sharing.

                                                                              • December 8, 2016 at 2:02 pm
                                                                              Bubbles
                                                                              Participant

                                                                                Here is an older link to a blog post I created re some of the initial work done with these meds:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/10/another-antibody-drug-conjugate-for.html

                                                                                I think progress has been made in some of the antibody-drug-conjugates.  But thought is might interest you to see some of the background.  I wish you and your dad well.  Celeste

                                                                                 

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