Please explain!

ugh. hearing about melanomas that have then spread are scary!

wonder what kind of testing they had done 2 yrs ago when it was 'just' on the skin and if there was anyway they could have known then they maybe didnt get it all – if thats the case.

ugh. hearing about melanomas that have then spread are scary!

wonder what kind of testing they had done 2 yrs ago when it was 'just' on the skin and if there was anyway they could have known then they maybe didnt get it all – if thats the case.

6th attempt to reply to the original post. This post  is a test and is  not SPAM!!!!!

6th attempt to reply to the original post. This post  is a test and is  not SPAM!!!!!

6th attempt to reply to the original post. This post  is a test and is  not SPAM!!!!!

First, Your friend has NOT been diagnosed with liver cancer!  They have been diagnosed with Melanoma that has spread (metastasized) to the liver. (Different DNA mutations involved.)  Two years ago (and still currently) it was/is not common to run the expensive DNA mutation tests on stage 1 or Stage 2 people.  Hopefully as the costs come down, this testing will increase.

– The BRAF gene provides instructions for making a protein that helps transmit chemical signals from outside the cell to the cell's nucleus.  This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion—-.

   The BRAF Gene and protein provide necessary functions for the human body.   Changes in the protein and DNA changes (mutations) in this gene permit uncontrolled cell reproduction  (vice apoptosis – normal cell death)  When a specific test is run for a specific DNA mutation is run, the result for that specific DNA mutation is positive (present) or negative (Not found.)   In this case it is usually assumed that the BRAF is 'normal', ie called "wild type BRAF". 

.Researchers are learning that specific targeted treatments can interrupt/block certain points in the signaling paths.  Sometimes permanently, sometimes temporarily, sometimes not at all, depending upon the individual. This is why an overall vaccine is currently impossible to develop for melanoma, much less for "cancer" in general.  

     What is good about knowing the positive or negative status of one's DNA mutation is that it can help one know what treatments are more likely to be beneficial to one or will be a waste of time and effort to try.  Treatments have their own negative side effects and can harm one that receives them whether or not they are also beneficial.  Preferably one day we will know what treatment will work on which of the mutations and on which cancers.

     It is NEVER known if they "GOT IT ALL" inspite of the doctors saying this.  What they mean is that they got clear margins on that tumor, not that they got all the melanoma cells from ones body.  There is NO way/test to verify that all have been removed from everywhere in the body.  This is why I would like to see studies showing that a low level adjuvant treatment could help eliminate the miscellaneous hiding cells.

First, Your friend has NOT been diagnosed with liver cancer!  They have been diagnosed with Melanoma that has spread (metastasized) to the liver. (Different DNA mutations involved.)  Two years ago (and still currently) it was/is not common to run the expensive DNA mutation tests on stage 1 or Stage 2 people.  Hopefully as the costs come down, this testing will increase.

– The BRAF gene provides instructions for making a protein that helps transmit chemical signals from outside the cell to the cell's nucleus.  This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion—-.

   The BRAF Gene and protein provide necessary functions for the human body.   Changes in the protein and DNA changes (mutations) in this gene permit uncontrolled cell reproduction  (vice apoptosis – normal cell death)  When a specific test is run for a specific DNA mutation is run, the result for that specific DNA mutation is positive (present) or negative (Not found.)   In this case it is usually assumed that the BRAF is 'normal', ie called "wild type BRAF". 

.Researchers are learning that specific targeted treatments can interrupt/block certain points in the signaling paths.  Sometimes permanently, sometimes temporarily, sometimes not at all, depending upon the individual. This is why an overall vaccine is currently impossible to develop for melanoma, much less for "cancer" in general.  

     What is good about knowing the positive or negative status of one's DNA mutation is that it can help one know what treatments are more likely to be beneficial to one or will be a waste of time and effort to try.  Treatments have their own negative side effects and can harm one that receives them whether or not they are also beneficial.  Preferably one day we will know what treatment will work on which of the mutations and on which cancers.

     It is NEVER known if they "GOT IT ALL" inspite of the doctors saying this.  What they mean is that they got clear margins on that tumor, not that they got all the melanoma cells from ones body.  There is NO way/test to verify that all have been removed from everywhere in the body.  This is why I would like to see studies showing that a low level adjuvant treatment could help eliminate the miscellaneous hiding cells.

First, Your friend has NOT been diagnosed with liver cancer!  They have been diagnosed with Melanoma that has spread (metastasized) to the liver. (Different DNA mutations involved.)  Two years ago (and still currently) it was/is not common to run the expensive DNA mutation tests on stage 1 or Stage 2 people.  Hopefully as the costs come down, this testing will increase.

– The BRAF gene provides instructions for making a protein that helps transmit chemical signals from outside the cell to the cell's nucleus.  This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion—-.

   The BRAF Gene and protein provide necessary functions for the human body.   Changes in the protein and DNA changes (mutations) in this gene permit uncontrolled cell reproduction  (vice apoptosis – normal cell death)  When a specific test is run for a specific DNA mutation is run, the result for that specific DNA mutation is positive (present) or negative (Not found.)   In this case it is usually assumed that the BRAF is 'normal', ie called "wild type BRAF". 

.Researchers are learning that specific targeted treatments can interrupt/block certain points in the signaling paths.  Sometimes permanently, sometimes temporarily, sometimes not at all, depending upon the individual. This is why an overall vaccine is currently impossible to develop for melanoma, much less for "cancer" in general.  

     What is good about knowing the positive or negative status of one's DNA mutation is that it can help one know what treatments are more likely to be beneficial to one or will be a waste of time and effort to try.  Treatments have their own negative side effects and can harm one that receives them whether or not they are also beneficial.  Preferably one day we will know what treatment will work on which of the mutations and on which cancers.

     It is NEVER known if they "GOT IT ALL" inspite of the doctors saying this.  What they mean is that they got clear margins on that tumor, not that they got all the melanoma cells from ones body.  There is NO way/test to verify that all have been removed from everywhere in the body.  This is why I would like to see studies showing that a low level adjuvant treatment could help eliminate the miscellaneous hiding cells.

ugh. hearing about melanomas that have then spread are scary!

wonder what kind of testing they had done 2 yrs ago when it was 'just' on the skin and if there was anyway they could have known then they maybe didnt get it all – if thats the case.