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Possible disease progression
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Possible disease progression

› Forums › General Melanoma Community › Possible disease progression

  • Post
    • November 27, 2018 at 3:11 pm
    Tracyyy
    Participant

      Hi, my mother had a CT today which showed enlarged hilar and mediastinal nodes in her chest and the oncologist immediately sent her for a PET/CT on Thursday. I was hoping so much for stable or clear results, now I am worried that the treatment has stopped working. She is on a trial Dab/Tram + spartalizumab immunotherapy /or placebo. In the end of summer she had pneumonitits, is it possible that those nodes are inflamed due to some infection….I really hope so.

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    • Replies
        • November 29, 2018 at 8:40 am
        Tracyyy
        Participant

          Has anyone experienced the same?

          • November 30, 2018 at 6:52 pm
          WithinMySkin
          Participant

            Hi Tracy. If your mother's pneumonitis was over the summer, her nodes should have gone down by now, but it could be another infection. Lymph nodes enlarge for all kinds of reasons – hopefully the scan will provide some clarity. Sending thoughts and prayers to you and your family!!

            Lauren

            • December 3, 2018 at 8:51 am
            Tracyyy
            Participant

              Hi, Lauren,

              Thanks for your reply! We got the results from the PET/CT and I am relieved because I think they are more positive than negative:

              "Increased metabolic activity in the area of the mediastianal lymph nodes which most probably is result of pseudo-progression or sarcoidosis /as a side effect from treatment/, but possbile disease progression cannot be completely excluded".

              There is still some uncertainty, but I really do hope it is a side effect from treatment. I reaserched "sarcoidosis" and seems like my mother has all the symptoms – breath shortness, mild chest pain, some rash on her upper legs and a tiny new granuloma in her lungs.  Now I am more convinced she is getting spartalizumab, not the placebo.

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