New Approach Quickly IDs Drug Candidates from Genome Sequence
Mon, 02/10/2014 – 2:45pm
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The new method identified a highly potent compound that causes cancer cells to attack themselves and die. (Source: The Scripps Research Institute/Disney lab) The new method identified a highly potent compound that causes cancer cells to attack themselves and die. (Source: The Scripps Research Institute/Disney lab) In research that could ultimately lead to many new medicines, scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed a potentially general approach to design drugs from genome sequence. As a proof of principle, they identified a highly potent compound that causes cancer cells to attack themselves and die.
“This is the first time therapeutic small molecules have been rationally designed from only an RNA sequence—something many doubted could be done,” said Matthew Disney, an associate professor at TSRI who led the study. “In this case, we have shown that that approach allows for specific and unprecedented targeting of an RNA that causes cancer.”
The technique, described in the journal Nature Chemical Biology online ahead of print, was dubbed Inforna.
http://www.dddmag.com/news/2014/02/new-approach-quickly-ids-drug-candidates-genome-sequence?et_cid=3761080&et_rid=657184103&type=cta
